A5034094116- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Ocular Surface and Contact Lens
- Bacterial biofilms and quorum sensing
- Selenium in Biological Systems
- Ocular Infections and Treatments
- Antimicrobial agents and applications
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Cardiac Arrest and Resuscitation
- Cellular Mechanics and Interactions
- Cardiac Valve Diseases and Treatments
- Nanoparticles: synthesis and applications
- Membrane Separation Technologies
- Graphene and Nanomaterials Applications
- Skin Protection and Aging
- 3D Printing in Biomedical Research
- Fuel Cells and Related Materials
- Antimicrobial Peptides and Activities
- Yersinia bacterium, plague, ectoparasites research
- Advanced Biosensing Techniques and Applications
- Advanced Sensor and Energy Harvesting Materials
- Insect symbiosis and bacterial influences
- Corneal Surgery and Treatments
Texas Tech University
2015-2024
Texas Tech University Health Sciences Center
2015-2024
Yale New Haven Hospital
2024
University of Arizona
2010-2023
Banner - University Medical Center Tucson
2015-2022
New America
2022
University of California, Berkeley
2021
University of Nigeria Teaching Hospital
2019
Lubbock Christian University
2018
Stanford University
2018
Significance Heart rate monitors, pacemakers, cardioverter-defibrillators, and neural stimulators constitute broad classes of electronic implants that rely on battery power for operation. Means harvesting directly from natural processes the body represent attractive alternatives these future types biomedical devices. Here we demonstrate a complete, flexible, integrated system is capable storing energy contractile relaxation motions heart, lung, diaphragm at levels meet requirements practical...
Mutualistic intracellular symbiosis between bacteria and insects is a widespread phenomenon that has contributed to the global success of insects. The symbionts, by provisioning nutrients lacking from diets, allow various occupy or dominate ecological niches might otherwise be unavailable. One such insect glassy-winged sharpshooter (Homalodisca coagulata), which feeds on xylem fluid, diet exceptionally poor in organic nutrients. Phylogenetic studies based rRNA have shown two types bacterial...
ABSTRACT Several insect groups have obligate, vertically transmitted bacterial symbionts that provision hosts with nutrients are limiting in the diet. Some of these bacteria been shown to descend from ancient infections. Here we show large group related insects including cicadas, leafhoppers, treehoppers, spittlebugs, and planthoppers host a distinct clade symbionts. This newly described symbiont lineage belongs phylum Bacteroidetes . Analyses 16S rRNA genes indicate phylogeny is completely...
Researchers report advances in materials and designs for skin-integrated devices capable of measuring acoustic signatures.
Abstract Endosymbioses are a major form of biological complexity affecting the ecological and evolutionary diversification many eukaryotic groups. These associations exemplified by nutritional symbioses insects for which phylogenetic studies have demonstrated numerous cases long‐term codiversification between bacterial host lineage. Some insects, including most leafhoppers (Insecta: Hemiptera: Cicadellidae), more than one symbiont within specialized cells, raising questions regarding...
Among the most difficult bacterial infections encountered in treating patients are wound infections, which may occur burn victims, with traumatic wounds, necrotic lesions people diabetes, and surgical wounds. Within a wound, infecting bacteria frequently develop biofilms. Many current dressings impregnated antimicrobial agents, such as silver or antibiotics. Diffusion of agent(s) from dressing damage destroy nearby healthy tissue well compromise effectiveness dressing. In contrast, agent...
Colonization of central venous catheters (CVCs) by pathogenic bacteria leads to catheter-related bloodstream infections (CRBSIs). These colonizing form highly antibiotic-resistant biofilms. Staphylococcus aureus is one the most frequently isolated pathogens in CRBSIs. Impregnating CVC surfaces with antimicrobial agents has various degrees effectiveness reducing incidence We recently showed that organoselenium covalently attached disks as an antibiofilm agent inhibited development S. In this...
In this study, we evaluate coaxial electrospun nanofibers with gelatin in the shell and poly(vinyl alcohol) (PVA) core as a potential vascular material by determining fiber surface roughness, well human platelet deposition activation under varying conditions. PVA scaffolds had highest roughness (Ra = 65.5 ± 6.8 nm) but lowest (34.2 5.8 platelets) comparison to 36.8 3.0 nm 168.9 29.8 (1 Gel:1 coaxial, Ra 24.0 1.5 150.2 17.4 platelets. 3 37.1 2.8 167.8 15.4 platelets). Therefore, chemical...
We found that insertion sequence (IS) elements are unusually abundant in the relatively recently evolved bacterial endosymbionts of maize weevils. Because multicopy can facilitate genomic recombination and deletion, this IS expansion may represent an early stage reduction is common most ancient endosymbionts.
When thermal injury damages the skin, physical barrier protecting underlying tissues from invading micro-organisms is compromised and host's immune system becomes supressed, facilitating colonization infection of burn wounds with micro-organisms. Within wound, bacteria often develop biofilms, which protect response enhance their resistance to antibiotics. As prophylactic use conventional antibiotics drives selection drug-resistant strains, novel agents prevent biofilm formation by wound...
Bacterial infection of acute and chronic wounds impedes wound healing significantly. Part this impediment is the ability bacterial pathogens to grow in dressings. In study, we examined effectiveness a polyurethane (PU) foam dressings coated with poly diallyl-dimethylammonium chloride (pDADMAC-PU) inhibit growth biofilm development by three main pathogens, Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, within dressing. pDADMAC-PU inhibited all pathogens. Time-kill...
Growth inhibition of the pathogen Staphylococcus aureus with currently available antibiotics is problematic in part due to bacterial biofilm protection. Although recently characterized natural products, including 3′,4′,5-trihydroxy-6,7-dimethoxy-flavone [1], 3′,4′,5,6,7-pentahydroxy-flavone [2], and 5-hydroxy-4′,7-dimethoxy-flavone [3], exhibit both antibiotic inhibitory activities, mode action such hydroxylated flavonoids respect S. yet be characterized. Enzymatic digestion high-resolution...
Right ventricular failure is a serious complication after left assist device placement. A 70-year-old male in decompensated heart with right the placement of device. single dual-lumen PROTEKDuo cannula was inserted percutaneously via internal jugular vein to draw blood from atrium and return into pulmonary artery using CentriMag system, by passing failing ventricle. The patient successfully weaned In comparison two-cannula conventional procedures, this ventrivular system improves...
Oral bacteria, including S treptococcus mutans and Streptococcus salivarius, contribute to tooth decay plaque formation; therefore, it is essential develop strategies prevent dental caries formation. We recently showed that organo-selenium compounds covalently attached different biomaterials inhibited bacterial biofilms. Our current study investigates the efficacy of an sealant (SeLECT-Defense TM sealant) in inhibiting S. salivarius biofilm formation vitro. The was synthesized material via...
The chemical composition and biofilm regulation of 15 metabolites from Teucrium polium are reported. Compounds were isolated a CH2Cl2–MeOH extract the aerial parts plant included iridoid phenylethanol glycosides monoterpenoid, together with nine known compounds. structures elucidated based on standard spectroscopic (UV, 1H 13C NMR), 2D NMR (1H–1H COSY, HMQC, HMBC, NOESY), and/or LC-ESIMS/MS data analyses. Inhibition biofilm-forming strain Staphylococcus aureus was observed exposure to compounds 7 8.
ABSTRACT Loss of the skin barrier facilitates colonization underlying tissues with various bacteria, where they form biofilms that protect them from antibiotics and host responses. Such wounds then become chronically infected. Topical antimicrobials are a major component chronic wound therapy, yet currently available topical vary in their effectiveness on biofilm-forming pathogens. In this study, we evaluated efficacy Next Science gel technology (NxtSc), novel agent designed to kill...
Studies assessing the safety and effectiveness of Del Nido cardioplegia for adult cardiac surgery remain limited. We investigated early outcomes after coronary artery bypass grafting (CABG) using single-dose vs. conventional multi-dose blood cardioplegia.
Background: Endophthalmitis associated with intraocular procedures is an infection of the eye that can rapidly result in substantial irreversible loss vision and may even lead to removal eye. Prevention strategies vary globally often include antibiotic use – consisting a broad spectrum mono-therapeutic agent. The purpose this study test efficacy value combinations cefuroxime (cefu), cefazolin (cefa), azithromycin (azith), and/or tobramycin (tob) as alternatives moxifloxacin. We...
The SynCardia total artificial heart (TAH) has emerged as an effective, life-saving biventricular replacement system for a wide variety of patients with end-stage failure. Although the clinical performance TAH is established, modern physiological characterization, in terms elastance behavior and pressure-volume (PV) characterization not been defined. Herein, we examine using nonejecting left ventricle, then characterize PV relation by varying preload afterload parameters Donovan Mock...