A5044604056- HIV Research and Treatment
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Cerebrospinal fluid and hydrocephalus
- Herpesvirus Infections and Treatments
- Fetal and Pediatric Neurological Disorders
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Spinal Dysraphism and Malformations
- Neuropeptides and Animal Physiology
- Drug Transport and Resistance Mechanisms
- Agricultural pest management studies
- Signaling Pathways in Disease
- interferon and immune responses
- Botanical Research and Chemistry
- Neonatal and fetal brain pathology
- HIV-related health complications and treatments
- Pediatric health and respiratory diseases
- Trace Elements in Health
- Alzheimer's disease research and treatments
- Mosquito-borne diseases and control
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytomegalovirus and herpesvirus research
University of Nebraska Medical Center
2017-2020
Nebraska Medical Center
2019
Xuan Wu Hospital of the Capital Medical University
2019
Drexel University
2015
Institute for Molecular Medicine
2015
Temple University
2010-2013
Thomas Jefferson University
1980-2006
The Ohio State University Wexner Medical Center
2001
The Ohio State University
2001
Bhabha Atomic Research Centre
1998
Abstract HIV‐1‐infected opiate abusers often exhibit an accelerated form of HIV‐1‐associated dementia and enhanced neurological dysfunction. Productive HIV‐1 infection microglia perivascular macrophages the resultant secretion neurotoxic molecules by these cells contribute to this phenomenon. In order understand role morphine in process, we performed a genome‐wide association study at micro RNA (miRNA) protein levels human monocyte‐derived (h‐mdms). A total 26 differentially expressed miRNA...
RNA interference, a natural biological phenomenon mediated by small interfering RNAs (siRNAs), has been demonstrated in recent studies to be an effective strategy against human immunodeficiency virus type 1 (HIV-1). In the present study, we used 21-bp chemically synthesized siRNA duplexes whose sequences were derived from gp41 gene, nef, tat, and rev regions of viral RNA. These are conserved select neurotropic strains HIV-1 (JR-FL, JR-CSF, YU-2). The designed siRNAs exerted potent antiviral...
Zika Virus (ZIKV) is primarily transmitted through mosquito bites. It can also be during sexual intercourse and in utero from mother to fetus. To gain preliminary insight into ZIKV pathology immune responses on route of transmission, rhesus macaques (RMs) were inoculated with (PRVABC59) via intravaginal (IVAG) (n = 3) or subcutaneous (sub Q) 2) routes. Systemic infection was observed all RMs, regardless the inoculation. After 9 days postinfection (dpi), not detected plasma IVAG-...
Opiate-abusing individuals are in the top three risk-factor groups for HIV infection. In fact, almost 30% of HIV-infected USA reported to abuse opiates, highlighting intersection drugs with HIV/AIDS. Opiate-abusers cognitively impaired and suffer from neurological dysfunctions that may lead high-risk sexual behavior, poor adherence antiretroviral regimens, hepatitis-C virus Collectively, these factors contribute accelerated central nervous system (CNS) disease progression. To understand role...
Particularly interesting new cysteine- histidine- rich protein (PINCH) is an adaptor that our data have shown required for neurite extension under stressful conditions. Our previous studies also report PINCH recalled by neurons showing decreased levels of synaptodendritic signaling proteins such as MAP2 or synaptophysin in the brains human immunodeficiency virus (HIV) patients. The current study addressed potential role(s) neurodegenerative diseases. Mass spectrometry predicted interaction...
The DC-SIGN receptor on human dendritic cells interacts with HIV gp120 to promote both infection of antigen-presenting and transinfection T cells. We hypothesized that in DC-SIGN-expressing cells, ligands such as dextrans antagonists peptide triazoles would inhibit potential complementary antagonist effects. To test this hypothesis, we evaluated the effects dextran (D66), isomaltooligosaccharides (D06), several (HNG156, K13, UM15) B-THP-1/DC-SIGN In surface plasmon resonance competition...
Recent spread of the promoter variant (4-κB) Human immunodeficiency virus-1 clade C (HIV-1C) strain is attributed to duplication Nuclear Factor Kappa B (NF-κB) binding sites and potential increased heroin consumption in India. To study underlying biology 4-κB HIV-1C rhesus macaques, we engineered a promoter-chimera (4NF-κB) Simian Immunodeficiency Virus (SHIV) by substituting Long Terminal Repeat (LTR) region consisting 4 NF-κB 3 Sp-1 with corresponding segment LTR SHIV AD8EO. The wild-type...