Objectives. There are no valid instruments to measure disease activity in Takayasu arteritis (TA). We aim provide a assess clinical with or without incorporating acute phase reactants. Methods. The Indian Clinical Activity Score (ITAS) was initially derived from manifestations scored the Disease Extent Index (DEI.Tak). ITAS validated by group of physicians scoring both live and paper cases for inter-rater reliability (IRR), convergence BVAS, correlation Physician’s Global Assessment (PGA)...

Quality of life (QOL) patients affected by various diseases is now recognized as an important outcome variable. Consenting with rheumatoid arthritis (American College Rheumatology criteria) were included in the study. was assessed using World Health Organization Life assessment, short form (WHOQOL-BREF). Disease activity Activity Score (DAS28) for 3 variables and functional disability Assessment Questionnaire (HAQ). Extra-articular manifestations (ExRA) diagnosed clinically. Seventy-five...

Abstract Objective There are sparse data on outcome of lupus nephritis from developing countries. This study looks at in Asian Indians. Methods retrospective included patients a single center over 20 years. Patients were treated as per standard protocols. The primary measure was chronic renal failure or death; the secondary end‐stage disease death. worst‐case scenario also calculated, considering those lost to followup first year events. Kaplan‐Meier survival curves and log rank test used...

Aim Methotrexate (MTX) has the potential to cause serious adverse reactions and even mortality. We analyzed predisposing factors outcome in patients with MTX-induced pancytopenia admitted into our unit from 1996 2015. Methods Patients were identified by departmental database search. Pancytopenia was defined as white blood cell count (WBC) < 3500 cells/mm3, hemoglobin (Hb) 11 g/dL platelet 150 000 cells/mm3. Severe WBC 2000 Hb 10 50 Results Forty-six included study (female = 35). Twenty-four...

Childhood SLE (cSLE) has a higher prevalence of lupus nephritis (LN), and there are ethnic variations in response to treatment as well outcome LN. There limited data on long-term LN cSLE from the Indian subcontinent.Retrospective analysis case records patients with (satisfying revised American College Rheumatology (ACR) 1997 criteria for diagnosis) age onset <18 years was conducted 1989 2013. Data clinical features, renal involvement biopsy findings, treatment, outcome, damage accrual...

Quality of life (QOL) patients affected by various diseases is now recognized as an important outcome variable. Consenting with rheumatoid arthritis (American College Rheumatology criteria) were included in the study. was assessed using World Health Organization Life assessment, short form (WHOQOL-BREF). Disease activity Activity Score (DAS28) for 3 variables and functional disability Assessment Questionnaire (HAQ). Extra-articular manifestations (ExRA) diagnosed clinically. Seventy-five...

Fibromyalgia (FM) has been shown to be common in patients with rheumatoid arthritis (RA), but studies on Asian are lacking. It remains unclear whether FM an adverse influence pain, fatigue, quality of life, and mood these patients, what its relationship is disease activity. We studied prevalence effects North Indian RA associations activity.This cross-sectional study included 200 equal number controls. Presence was defined using the American College Rheumatology 1990 criteria. Pain fatigue...

Introduction About 10-20% of systemic lupus erythematosus (SLE) patients have onset in childhood and more severe organ involvement. Survival juvenile SLE is improving worldwide. Long-term data from developing countries scarce. Methods Clinical laboratory at initial presentation follow-up visits were retrieved clinic files, hospital information system personal interviews. Treatment received, complications, flares, outcomes death recorded. was calculated using Kaplan-Meier survival curves...

Rheumatology in India, albeit old, has lagged behind research on epidemiology and outcomes of chronic rheumatic diseases. The realization about paucity Indian data created the felt need for cohort-building sustainable research. With this comes dawn collaborative Myositis is one such rare disease with considerable morbidity mortality, where little known behavior treatment practices setting. In recent years availability myositis-specific autoantibodies, newer clinic-serologic associations have...

Introduction: Preventive strategies to reduce radiation-induced harm among anaesthesiologists are directed by the National Council on Radiation Protection and Measurements US Environmental Agency. These instructions underscore necessity of minimising exposure intensity duration, maintaining distance from radiation source, employing shielding against both primary dispersed radiation. This study sought assess knowledge apprehension anaesthesia residents in teaching hospitals Karachi via an...

Objective: To describe the clinical profile and outcome of patients with catastrophic antiphospholipid syndrome (CAPS) from a tertiary care Rheumatology centre in North India. Methods: A retrospective analysis data between 1990 March 2024 was done. Those rapid involvement three or more organ systems moderate to high titres antibodies (aPL) at least once were considered physician-diagnosed CAPS. Results: Fourteen as cases The majority females, median age 28 years (26.25–37.25). Two-thirds had...

ABSTRACT Aim and Objectives To assess the role of newer biomarkers like neutrophil Z, myeloid‐related protein 8/14 (MRP 8/14), IL‐6, sCD14, CD64 (nCD64) to distinguish flare from infection in febrile lupus patients. Methods In this prospective multicentric observational study determine etiology fever patients, addition routine tests, serum procalcitonin, X, Y, Z were done. MRP8/14, IL‐6 done by ELISA. nCD64 expression was measured flow cytometry. All these assessed individually combination...

Aim Leprosy classically presents with cutaneous and neural involvement. Rheumatological manifestations are frequent, although often under-recognized. At times, these may present to a rheumatology clinic prior the diagnosis of leprosy. Herein, we our experience patients referred various rheumatological disorders who were subsequently diagnosed as having Methods This retrospective study (January 2001–September 2010) was carried out at Department Clinical Immunology, Sanjay Gandhi Postgraduate...

We explored causes of in-hospital mortality in patients with inflammatory myositis at a tertiary care center Northern India.Records adults and children diagnosed dermatomyositis (DM), polymyositis, or anti-synthetase syndrome (ASSD) who died between 2000 2018 were reviewed, death determined.Of the 38 patients, 20 had DM (including 2 clinically amyopathic DM), 4 juvenile DM, 12 whereas ASSD. Median age was 42.0 (interquartile range, 32.8-52.5) years. disease duration 18.5 2.0-23.5) months....

Introduction Juvenile dermatomyositis (JDM) is a rare multisystem disorder of childhood primarily involving the skeletal muscles and skin. Patients methods The case records patients with JDM seen at our centre in last 10 years were reviewed data on clinical presentation, management, outcome complications retrieved. Results Eighteen (nine boys) diagnosed as median age presentation 12.5 years, duration illness 9.25 months follow-up 24 months. At rash was all patients, 17 had muscle weakness,...

To assess the frequency and risk factors of asymptomatic vertebral fractures in inflammatory myositis.Dorsal lumbar spine lateral radiographs were taken for adults with myositis scored using Genant's semi-quantitative technique. Demographic data, weight, height, postmenopausal status, duration corticosteroid use, drug intake, co-morbidities past history recorded. Bone mineral density (BMD) was assessed dual-energy X-ray absorptiometry (DEXA). Myositis Damage Index (MDI) also assessed. All...

Abstract Aim Henoch‐Schönlein purpura (HSP), a primary vasculitis, characterized by purpura, abdominal pain, arthritis and renal involvement, is predominantly disease of childhood. However, rarely it can occur in adults whom believed to be more severe form with poor outcomes. We aimed answer if the age onset affected clinical spectrum outcomes north Indian population. Hence, we studied differences between adult‐onset HSP childhood‐onset HSP. Methods Case records all adult patients diagnosed...

To study the difference in clinical presentation of patients ankylosing spondylitis (AS) with and without peripheral arthritis.We performed a retrospective analysis case records 271 AS seen last 15 years at our center diagnosed as according to modified New York criteria. We compared features between arthritis.There were 253 (93%) men M:F ratio 9:1, 78 (28%) had Juvenile onset (JAS). Mean age disease was 22.4 +/- 9.3 years. Eighty-four arthritis. Patients arthritis significantly higher...

Abstract Introduction Takayasu’s arteritis (TA) affects young women in the childbearing age group. We studied obstetric outcomes these patients before and after disease onset. Methods Women aged more than 18 years with (ACR 1990 criteria) were included. Demographic data, clinical features, activity using Indian Takayasu Arteritis score (ITAS), Disease Extent Index for TA (DEI.TaK) damage assessment Damage (TA), history of conception maternal fetal recorded from hospital records telephonic...

Background Mortality in SLE has a bimodal peak with early deaths mainly related to disease activity and infection. Although mortality reduced over years, it is still two three folds compared the general population. In India due increased burden of infection limited access health care, causes may be different. Methods Retrospective, review records all adult patients fulfilling ACR 1997 criteria, who died hospital between 2000-2019 at teaching was done. addition, baseline clinical features...