David A. Sacks

ORCID: 0000-0003-3444-6476
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About
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Research Areas
  • Gestational Diabetes Research and Management
  • Pregnancy and preeclampsia studies
  • Bariatric Surgery and Outcomes
  • Birth, Development, and Health
  • Climate Change and Health Impacts
  • Air Quality and Health Impacts
  • Maternal and Perinatal Health Interventions
  • Maternal Mental Health During Pregnancy and Postpartum
  • Diabetes Management and Research
  • Preterm Birth and Chorioamnionitis
  • COVID-19 Impact on Reproduction
  • Neonatal Respiratory Health Research
  • Pregnancy-related medical research
  • Global Health Care Issues
  • Maternal and fetal healthcare
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Diabetes Management and Education
  • Urban Green Space and Health
  • Diabetes and associated disorders
  • Obesity, Physical Activity, Diet
  • Noise Effects and Management
  • Prenatal Substance Exposure Effects
  • COVID-19 and healthcare impacts
  • Energy and Environment Impacts
  • Cancer Risks and Factors

Kaiser Permanente
2015-2025

University of Southern California
2007-2024

Los Angeles Medical Center
1975-2023

Huntington Hospital
2023

Prevention Group
2019

Royal Victoria Hospital
2019

University of Ulster
2019

Georgetown-Howard Universities Center for Clinical and Translational Science
2018

Camden and Campbelltown Hospitals
2018

MedStar Health
2018

It is controversial whether maternal hyperglycemia less severe than that in diabetes mellitus associated with increased risks of adverse pregnancy outcomes.

10.1056/nejmoa0707943 article EN New England Journal of Medicine 2008-05-07

The Fifth International Workshop-Conference on Gestational Diabetes Mellitus (GDM) was held in Chicago, IL, 11–13 November 2005 under the sponsorship of American Association. meeting provided a forum for review new information concerning GDM areas pathophysiology, epidemiology, perinatal outcome, long-range implications mother and her offspring, management strategies. New recommendations related to each these major topics are summarized report that follows. The issues regarding strategies...

10.2337/dc07-s225 article EN Diabetes Care 2007-06-27

The purpose of this study was to assess changes in the prevalence preexisting diabetes (diabetes antedating pregnancy) and gestational mellitus (GDM) from 1999 through 2005.In retrospective 175,249 women aged 13-58 years with 209,287 singleton deliveries >or=20 weeks' gestation 2005 all Kaiser Permanente hospitals southern California, information clinical databases birth certificates used estimate GDM.Preexisting identified 2,784 (1.3%) pregnancies, rising an age- race/ethnicity-adjusted...

10.2337/dc07-2345 article EN Diabetes Care 2008-04-29

OBJECTIVE To report frequencies of gestational diabetes mellitus (GDM) among the 15 centers that participated in Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study using new International Association Diabetes Groups (IADPSG) criteria. RESEARCH DESIGN AND METHODS All participants underwent a 75-g oral glucose tolerance test between 24 32 weeks’ gestation. GDM was retrospectively classified IADPSG criteria (one or more fasting, 1-h, 2-h plasma concentrations equal to greater than...

10.2337/dc11-1641 article EN cc-by-nc-nd Diabetes Care 2012-02-10

<h3>Importance</h3> The sequelae of gestational diabetes (GD) by contemporary criteria that diagnose approximately twice as many women previously used are unclear. <h3>Objective</h3> To examine associations GD with maternal glucose metabolism and childhood adiposity 10 to 14 years’ postpartum. <h3>Design, Setting, Participants</h3> Hyperglycemia Adverse Pregnancy Outcome (HAPO) Study established levels during pregnancy perinatal outcomes the follow-up study evaluated long-term (4697 mothers...

10.1001/jama.2018.11628 article EN JAMA 2018-09-11

OBJECTIVE Whether hyperglycemia in utero less than overt diabetes is associated with altered childhood glucose metabolism unknown. We examined associations of gestational mellitus (GDM) not confounded by treatment glycemia the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. RESEARCH DESIGN AND METHODS HAPO Follow-up Study (FUS) included 4,160 children ages 10–14 years who completed all or part an oral tolerance test (OGTT) whose mothers had a 75-g OGTT at ∼28 weeks gestation...

10.2337/dc18-1646 article EN Diabetes Care 2019-01-17

OBJECTIVE The International Association of Diabetes in Pregnancy Study Groups (IADPSG) criteria for diagnosis gestational diabetes mellitus (GDM) identifies women and infants at risk adverse outcomes, which are also strongly associated with maternal overweight, obesity, excess weight gain. RESEARCH DESIGN AND METHODS We conducted a retrospective study 9,835 who delivered ≥20 weeks’ gestation; had prenatal, 2-h, 75-g oral glucose tolerance test; were not treated diet, exercise, or...

10.2337/dc12-0741 article EN cc-by-nc-nd Diabetes Care 2012-08-14

This study examined associations of maternal glycemia during pregnancy with childhood glucose outcomes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort.

10.2337/dc18-2021 article EN Diabetes Care 2019-01-07

To examine whether pregnancy weight gains outside the Institute of Medicine (IOM) recommendations and rates maternal gain are associated with neonatal complications.In a cohort 45,245 women who delivered singletons at Kaiser Permanente Medical Care Program Northern California in 1996-1998 did not have gestational diabetes as 24-28 weeks gestation, we conducted nested case-control study three case groups: macrosomia (birth more than 4,500 g, n=391), hypoglycemia (plasma glucose less 40 mg/dL,...

10.1097/01.aog.0000242568.75785.68 article EN Obstetrics and Gynecology 2006-11-01

OBJECTIVE To examine the association between levels of hyperglycemia, determined by each prenatal oral glucose tolerance test (OGTT) value (fasting, 1 and 2 h), maternal perinatal outcomes to determine whether risk for these differs women whose value(s) equaled or exceeded thresholds gestational diabetes mellitus (GDM) established International Association Diabetes in Pregnancy Study Groups (IADPSG). RESEARCH DESIGN AND METHODS This article discusses a retrospective study 8,711 women,...

10.2337/dc10-1445 article EN cc-by-nc-nd Diabetes Care 2010-09-15

OBJECTIVE To estimate the prevalence of postpartum glucose testing within 6 months pregnancies complicated by gestational diabetes mellitus (GDM), assess factors associated with and timing after delivery, report test results among tested women. RESEARCH DESIGN AND METHODS This was a retrospective study 11,825 women who were identified as having GDM using 100-g oral tolerance (OGTT) from 1999 to 2006. Postpartum (75-g 2-h OGTT or fasting plasma [FPG]) delivery laboratory databases are...

10.2337/dc09-2095 article EN cc-by-nc-nd Diabetes Care 2009-12-29

Epidemiological findings are inconsistent regarding the associations between air pollution exposure during pregnancy and gestational diabetes mellitus (GDM). Several limitations exist in previous studies, including potential outcome misclassification, unassessed confounding, lack of simultaneous consideration mixtures particulate matter (PM) constituents.To assess association GDM maternal residential to pollution, joint effect mixture pollutants PM constituents.Detailed clinical data were...

10.1016/j.envint.2021.106888 article EN cc-by-nc-nd Environment International 2021-09-24

Recent studies have reported inconsistent associations between maternal residential green space and preterm birth (PTB, born < 37 completed gestational weeks). In addition, windows of susceptibility during pregnancy not been explored potential interactions with air pollution exposures are still unclear.To evaluate the relationships PTB, identify susceptibility, explore pollution.Birth certificate records for all births in California (2001-2008) were obtained. The Normalized Difference...

10.1016/j.envint.2020.105804 article EN cc-by-nc-nd Environment International 2020-06-05

Insulin resistance (IR) is a characteristic feature of non-insulin-dependent diabetes mellitus (NIDDM) as well obesity, and majority NIDDM patients are obese. To assess the effect obesity independent on IR, we studied relationship between IR in 65 normal 58 subjects; used body mass index (BMI) measure glucose infusion rate (GINF) during euglycemic hyperinsulinemic (120 mU · m−2 min−1) clamp IR. In lean subjects, GINF was 57.7 ± 2.2 μmol kg−1 min−1 (10.4 0.4 mg subjects were markedly...

10.2337/diab.44.9.1121 article EN Diabetes 1995-09-01

The National Institute of Diabetes and Digestive Kidney Diseases convened a workshop on research gaps in gestational diabetes mellitus (GDM) with focus 1) early pregnancy diagnosis treatment 2) pharmacologic strategies. This article summarizes the proceedings workshop. In pregnancy, appropriate diagnostic criteria for GDM remain poorly defined, an effect risk adverse outcomes has not been demonstrated. Despite many small randomized controlled trials glucose-lowering medication GDM, our...

10.1097/aog.0000000000002726 article EN Obstetrics and Gynecology 2018-07-11
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