A5019742187- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune responses and vaccinations
- IL-33, ST2, and ILC Pathways
- Herpesvirus Infections and Treatments
- Reproductive System and Pregnancy
- Immune Response and Inflammation
- Bacterial Infections and Vaccines
Cornell University
2021-2025
CD8 + T cells are classically recognized as adaptive lymphocytes based on their ability to recognize specific foreign antigens and mount memory responses. However, recent studies indicate that some antigen-inexperienced can respond innate cytokines alone in the absence of cognate cell receptor stimulation, a phenomenon referred bystander activation. Here, we demonstrate neonatal undergo robust diverse program activation, which corresponds enhanced innate-like protection against unrelated...
Microbial exposure during development can elicit long-lasting effects on the health of an individual. However, how microbial in early life leads to permanent changes immune system is unknown. Here, we show that environment alters set point for susceptibility by altering developmental architecture CD8+ T cell compartment. In particular, results preferential expansion highly responsive fetal-derived cells persist into adulthood and provide host with enhanced protection against intracellular...
Abstract Cytomegalovirus (CMV) leads to a unique phenomenon known as ‘memory inflation,’ where antigen-specific memory CD8+ T cells continue accumulate in the peripheral tissues during latent stage of infection. However, it is still not clear how inflating pool generated and maintained. In this study, we used murine cytomegalovirus (MCMV) model persistent infection fate-mapping mice determine dynamics cell recruitment into pool. We found that neonatal exposure CMV an expansion newly made...
The most common congenital viral infection is CMV, which leads to numerous neurologic disabilities. Using a mouse model of we previously determined that Ag-specific CD8+ T cells traffic the brain in CCR9-dependent manner. mechanism by these acquire "brain-tropic" phenotype remains unclear. In this study, identify key factor imprints homing specificity on cells, source production, and location where CCR9 expression induced. Specifically, discovered induced retinoic acid-producing CD8α+...
Abstract The immune system is stratified into layers of specialized cells with distinct functions. Recently, Lin28b was shown to serve as a master regulator fetal lymphopoiesis, programming the development more innate-like lymphocytes in early life. However, it remains unclear whether specifies innate functions conventional adaptive lymphocytes. In this report, we discovered that promotes lineage CD8+ T capable protecting host against wide variety pathogens absence TCR stimulation. Using...
CD8+ T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. However, mechanisms by which cells are recruited to remain unclear. Using a mouse model of CMV, we found gut-homing chemokine receptor (CCR9) was preferentially expressed in localized postinfection. In absence CCR9 or CCL25 (CCR9's ligand) expression, failed migrate key sites protect host from severe forms disease. Interestingly, that expression on also responsible for spatial temporal...
Abstract Evidence has shown that microbial exposure in early life can have long-lasting effects on the health status of an individual. However, underlying basis how microbes shape immune system is not well understood. In this study, we utilized a novel pet shop mouse model and compared development function laboratory mice raised either clean (SPF) or dirty (pet-shop) environment. When challenged two groups with intracellular pathogen adulthood, found environment mounted more robust CD8+ T...
Abstract Lin28b serves as a master regulator of fetal lymphopoiesis and promotes the development more innate-like lymphocytes in early life. However, it is still unclear how alters function CD8+ T cells protects host against infection. In this report we examined transcriptionally epigenetically programs neonatal for innate immune defense. We found that murine possess transcriptomes, are responsive to cytokines absence antigen produce broader spectrum compared their adult counterparts. This...