A5076059012- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Neutropenia and Cancer Infections
- Sarcoma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Childhood Cancer Survivors' Quality of Life
- Pluripotent Stem Cells Research
- Reproductive Biology and Fertility
- Transplantation: Methods and Outcomes
- Ethics and Legal Issues in Pediatric Healthcare
- Fungal Infections and Studies
- Tracheal and airway disorders
- Neuroblastoma Research and Treatments
- Respiratory viral infections research
- Antifungal resistance and susceptibility
- Testicular diseases and treatments
- Virus-based gene therapy research
- Digital Imaging for Blood Diseases
- Brain Metastases and Treatment
- Oral health in cancer treatment
Ospedale Civile Di Ivrea
2024
University of Turin
1998-2022
Ospedale Regina Margherita
2009-2022
Piedmont Reference Center for Epidemiology and Cancer Prevention
2020-2022
Boston Children's Hospital
2008-2015
Italian Association for Cancer Research
2004
Candiolo Cancer Institute
1997
A. O. Ordine Mauriziano di Torino
1997
Torino e-district
1997
Abstract Objectives To demonstrate the efficacy of laser photobiomodulation (PBM) compared to that placebo on severe oral mucositis (OM) in pediatric oncology patients. The primary objective was reduction OM grade (World Health Organization [WHO] scale) 7 days after starting PBM. Secondary objectives were pain, analgesic consumption, and incidence side effects. Methods One hundred one children with WHO > 2 chemotherapy‐induced enrolled eight Italian hospitals. Patients randomized either...
Allogeneic hematopoietic cell transplant (HCT) remains the only curative therapy for many hematologic malignancies but it is limited by high nonrelapse mortality (NRM), primarily from unpredictable control of graft-versus-host disease (GVHD). Recently, post-transplant cyclophosphamide demonstrated improved GVHD in allogeneic bone marrow HCT. Here we explore peripheral blood stem transplantation (alloPBSCT). Patients with high-risk received alloPBSCT HLA-matched unrelated/related donors....
Outcome data were collected from the European Society for Blood and Marrow Transplantation registry on 373 children 120 centers with relapsed leukemia (214 acute lymphoblastic [ALL] 159 myelogenous [AML]) who underwent second allogeneic hematopoietic stem cell transplantation (HSCT) between 2004 2013. Overall survival (OS) was 38% at 2 years 29% 5 years, leukemia-free (LFS) 30% 25% years. Median follow-up after HSCT 36.4 months in ALL group 50.2 AML group. In group, OS 43% 33% LFS 34% 31%...
Data on the epidemiology of bacteremias and invasive fungal diseases (IFD) in children with acute myeloid leukemia (AML) are scarce.In a multi-center, retrospective study, we analyzed proportion, rate per 1,000 person-days at risk, cumulative risk IFD AML.Between January 1998 December 2005, 240 were treated for AML 8 Italian Centers, total 521 treatment courses 63,232 risk. Bacteremia was observed 32% seen 10% (P < 0.0001), rates 2.62 0.84, respectively 0.001). There significantly higher...
Abstract BACKGROUND: A phase 2 trial was carried out to assess the antineoplastic activity of courses cyclophosphamide‐etoposide in relapsed osteosarcoma patients. METHODS: Twenty‐six patients with a median age 18.5 years (8.3‐47.1) were enrolled. Seven first relapse (27%), 11 second (42%), 7 third and 1 fourth (4%). Eighteen had bone metastasis at study entry (69%). Cyclophosphamide given 4 g/m on Day followed by etoposide 200 mg/m Days 2, 3, 4. Second cyclophosphamide planned 21 days 28...
This study was aimed at ascertaining whether extracorporeal photopheresis (ECP) is an effective treatment for pediatric patients with steroid resistant graft versus host disease (GvHD). Fifteen acute GvHD (aGvHD) and 10 chronic (cGvHD) were enrolled in the study. At start of ECP protocol, aGvHD staged as II (n=7), III (n=4), IV (n=4). The response rate 100% II, 75% III, finally 0% (P=0.02). In multivariate analysis, strongest predictor severity: 100%, III-IV 30% [relative risk (RR) 5.071,...
Background Extracorporeal photopheresis ( ECP ) has been shown as active therapy for graft‐versus‐host disease GVHD ). Study Design and Methods The aim was to ascertain the role of in 71 patients with steroid‐refractory or ‐dependent acute chronic aGVHD cGVHD special focus on hematologic variables staging classification. A total 34 were treated 37 . Results overall response rate ORR 65% complete ‐free survival 50% (95% confidence interval [ CI ], 36%‐70%). 81% while , 34%‐73%). associated...
Patients with acute graft-versus-host disease (GvHD) grade I were randomized to an observation arm (n=85) or a treatment (n=86) consisting of 6-methylprednisolone 1 mg/kg/day, after stratification for age and donor type. The primary end point was development II–IV GvHD. cumulative incidence GvHD 50% in the 33% (P=0.005). However, III–IV comparable (13% vs. 10%, respectively; P=0.6), this true sibling alternative transplants. Moderate/severe chronic also (17% 9%). In multivariate analysis,...
Paediatric patients with acute myeloid leukaemia (AML) who fail induction due to primary resistance chemotherapy account for a significant proportion of cases and have particularly dismal prognosis. We report the clinical biological data, final outcome 48 paediatric primary-resistant AML enrolled in Associazione Italiana di Ematologia e Oncologia Pediatrica 2002/01 trial. These had significantly higher white blood cell count at diagnosis compared other patients. Cytogenetic molecular...
Combined direct antineoplastic activity and the long-lasting immunological effects of allogeneic hematopoietic cell transplant (HCT) can cure many hematological malignancies, but broad adoption requires non-relapse mortality (NRM) rates graft-versus-host disease (GVHD) control. Recently, posttransplant cyclophosphamide (PTCy) given after a bone marrow significantly reduced GVHD-incidence, while PTCy with tacrolimus/mofetil mycophenolate (T/MMF) showed following peripheral blood stem...
Bronchiolitis is an acute viral infection of the lower respiratory tract that affects infants and young children. Respiratory syncytial virus (RSV) most common causative agent; however, other viruses can be involved in this disease. We retrospectively reviewed clinical features aged less than 12 months hospitalized for bronchiolitis our Pediatric Units Chivasso, Cirié, Ivrea Piedmont, Northern Italy, over two consecutive seasons (September 2021–March 2022 September 2022–March 2023)....
Abstract BACKGROUND Outcome data were analyzed for 27 patients who affected with recurrent or newly diagnosed high‐risk brain tumors and underwent high‐dose chemotherapy triethylenethiophosphoramide (thiotepa) etoposide in addition to autologous stem cell transplantation between May 1992 September 2002. METHODS Fifteen males 12 females (median age, 11 years) included the study. Twelve had tumors, 15 tumors. The conditioning regimen consisted of thiotepa 900 mg/m 2 1500 over 3 days starting...
Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) still represents a major challenge. We report the experience of Italian Association Pediatric Hematology and Oncology (AIEOP) with allogeneic hematopoietic stem cell transplantation (HSCT) in children Ph+ ALL from 1990 to 2008. Sixty-nine patients received HSCT either related (37, 54%) or an unrelated (32, 46%) donor. Twenty-five (36%) underwent before 2000 44 (64%) after 2000. Twenty-three (33%) Imatinib mesylate treatment seven...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective therapy for patients with relapsed acute myeloid leukemia. In this retrospective, multicenter study, we analyzed the outcome of 63 children (median age, 7 y; range, 0.2 to 17) who received unmanipulated allo-HSCT in second complete remission. Either a matched family donor or unrelated was used 29 (46%) and 34 (54%) patients, respectively. The source bone marrow 53 (84%), peripheral blood (11%), cord 3 (5%)....
Robust T cell function recovery has been shown to be crucial in determining allogeneic hematopoietic stem transplantation (HSCT) outcome, and there is growing evidence that the thymus plays a central role regulating this process. We performed long-term analysis of thymic activity population pediatric patients undergoing HSCT by signal joint receptor excision circle (sjTREC) quantification. In study, characterized follow-up (median, 72 months), we found with higher levels sjTRECs before had...