A5064387290- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Management and Research
- Mesenchymal stem cell research
University of Groningen
2017-2025
University Medical Center Groningen
2017-2025
Extracellular matrix (ECM) molecules have several functions in pancreatic islets, including provision of mechanical support and prevention cytotoxicity during inflammation. During islet isolation, ECM connections are damaged, not restored after encapsulation transplantation. Inclusion specific combinations collagen type IV laminins immunoisolating capsules can enhance survival islets. Here we investigated whether also lower susceptibility human islets to cytokine-mediated cytotoxicity. To...
Pancreatic islet transplantation (PIT) is a promising treatment for type 1 diabetes (T1D) but faces challenges pre- and post-transplantation. Co-transplantation with mesenchymal stromal cells (MSCs), known their regenerative properties, has shown potential in improving PIT outcomes. This study examined the secretome of islets cultured alone compared to secretomes co-cultured adipose-derived (ASCs), subtype MSCs, under transplantation-relevant stressors: normoxia, cytokines, high glucose,...
Abstract Transplantation of microencapsulated pancreatic cells is emerging as a promising therapy to replenish β‐cell mass lost from auto‐immune nature type I diabetes mellitus (T1DM). This strategy intends use micrometer‐sized microgels provide immunoprotection transplanted avoid chronic application immunosuppression. Clinical encapsulation has remained elusive due often limited production throughputs and body's immunological reactions implanted materials. article presents high‐throughput...