A5038588926- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Osteoarthritis Treatment and Mechanisms
- Additive Manufacturing and 3D Printing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Medical and Biological Ozone Research
- Cardiac Fibrosis and Remodeling
- Neuroscience and Neural Engineering
- Cellular Mechanics and Interactions
- Cytokine Signaling Pathways and Interactions
- Facial Trauma and Fracture Management
- Silk-based biomaterials and applications
- Cell Adhesion Molecules Research
- Laser-Ablation Synthesis of Nanoparticles
- Cancer Cells and Metastasis
- Supercapacitor Materials and Fabrication
- Mesenchymal stem cell research
- Family Business Performance and Succession
- Dental materials and restorations
- bioluminescence and chemiluminescence research
- Angiogenesis and VEGF in Cancer
- Bone Metabolism and Diseases
- Diabetes and associated disorders
University of Twente
2022-2025
Technical University of Darmstadt
2020
We demonstrate a cost-effective synthesis route that provides Si-based anode materials with capacities between 2000 and 3000 mAh·gSi-1 (400 600 mAh·gcomposite-1), Coulombic efficiencies above 99.5%, almost 100% capacity retention over more than 100 cycles. The composite is prepared from highly porous silicon (obtained by reduction of silica) encapsulation in an organic carbon polymer-derived oxycarbide (C/SiOC) matrix. Molecular dynamics simulations show the morphology delivers free volume...
Bioactive glasses (BGs) are promising bone substitute materials. However, under certain circumstances BGs such as the well-known 45S5 Bioglass® (composition in wt%: 45.0 SiO2, 24.5 Na2O, CaO, 6.0 P2O5) act cytotoxic due to a strong increase pH caused by burst release of sodium ions. A potential alternative is sodium-reduced fluoride-containing BG belonging CaO–MgO–SiO2 system, namely BG1d-BG 46.1 28.7 8.8 MgO, 6.2 P2O5, 5.7 CaF2, 4.5 Na2O), that has already been evaluated in-vitro, in-vivo...
Abstract Embedded 3D bioprinting has great value for the freeform fabrication of living matter. However, embedded is currently limited to highly viscous liquid baths or liquid‐like solid baths. In contrast, prior crosslinking, most hydrogels are formulated as low‐viscosity solutions and therefore not directly compatible with due low shape fidelity poor print stability. The authors here present a method enable ink (LoV3D) bioprinting, based on aqueous two‐phase stabilization ink‐bath...
Abstract Engineered living microtissues such as cellular spheroids and organoids have enormous potential for the study regeneration of tissues organs. Microtissues are typically engineered via self‐assembly adherent cells into spheroids, which characterized by little to no cell–material interactions. Consequently, 3D microtissue models currently lack structural biomechanical biochemical control over their internal microenvironment resulting in suboptimal functional performance limited stem...
Abstract Osteoarthritis (OA) is a multifactorial degenerative joint disease of which the underlying mechanisms are yet to be fully understood. At molecular level, multiple factors including altered signaling pathways, epigenetics, metabolic imbalance, extracellular matrix degradation, production metalloproteinases, and inflammatory cytokines, known play detrimental role in OA. However, these do not initiate OA, but mediators or consequences disease, while many other causing etiology OA still...
Given the dynamic nature of engineered vascular networks within biofabricated tissue analogues, it is instrumental to have control over constantly evolving biochemical cues synthetic matrices throughout remodeling. Incorporation pro-angiogenic endothelial growth factor (VEGF165) specific aptamers into cell-instructive polymer shown be pivotal for spatiotemporally controlling local bioactivity VEGF that selectively elicit cell responses. To harness this effect and quantitatively unravel its...
Abstract Oxygen releasing biomaterials can facilitate the survival of living implants by creating environments with a viable oxygen level. Hydrophobic generating microparticles (HOGMPs) encapsulated calcium peroxide (CPO) have recently been used in tissue engineering to release physiologically relevant amounts for several weeks. However, using CPO is mediated via generation toxic levels hydrogen (H 2 O ). The incorporation antioxidants, such as catalases, potentially reduce H levels....
Cardiac fibrosis occurs following insults to the myocardium and is characterized by abnormal accumulation of non-compliant extracellular matrix (ECM), which compromises cardiomyocyte contractile activity eventually leads heart failure. This phenomenon driven activation cardiac fibroblasts (cFbs) myofibroblasts results in changes ECM biochemical, structural mechanical properties. The lack predictive vitro models has so far hampered search for innovative treatments, as most cellular-based...
3D bioprinting approaches offer highly versatile solutions to replicate living tissue and organ structures. While current can generate desired shapes spatially determined patterns, the material selection for embedded has remained limited, as it relied on use of viscous, shear-thinning, or liquid-like solid materials create shape controlled constructs, which could then be modified downstream via multi-step processes. We here explore aqueous two-phase system stabilized low viscous in...
Osteoarthritis (OA) is a musculoskeletal degenerative disease characterized by alterations in cartilage and subchondral bone leading to impaired joint function. OA disproportionally affects females more than males, yet the molecular mechanisms underlying these biological sex differences remain elusive. Current therapeutic strategies halt progression of are still lacking, part due limited predictive potential standard models which often do not account for disparities. Herein, an organ-on-chip...
Osteoarthritis (OA) is a degenerative disease of the joints for which no curative treatment exists. Intra-articular injection stem cells explored as regenerative approach, but rapid clearance from site limits therapeutic outcome. Microencapsulation mesenchymal (MSCs) can extend retention time MSCs, outcomes few studies currently performed are conflicting. We hypothesize that composition micromaterial's shell plays deciding factor in outcome intra-articular MSC injection. To this end, we...
We establish a versatile hydrogel platform based on modular building blocks that allows the design of hydrogels with tailored physical architecture and mechanical properties. demonstrate its versatility by assembling (i) fully monolithic gelatin methacryloyl (Gel-MA) hydrogel, (ii) hybrid composed 1:1 Gel-MA nanoparticles, (iii) particulate methacryloyl-modified nanoparticles. The were formulated to exhibit same solid content comparable storage modulus but different stiffness viscoelastic...
Abstract Transplantation of microencapsulated pancreatic cells is emerging as a promising therapy to replenish β‐cell mass lost from auto‐immune nature type I diabetes mellitus (T1DM). This strategy intends use micrometer‐sized microgels provide immunoprotection transplanted avoid chronic application immunosuppression. Clinical encapsulation has remained elusive due often limited production throughputs and body's immunological reactions implanted materials. article presents high‐throughput...
Abstract The vascular tree is crucial for the survival and function of large living tissues. Despite breakthroughs in 3D bioprinting to endow engineered tissues with blood vessels, there currently no approach engineer high‐density capillary networks into a scalable manner. Here, photoannealing microtissue (PALM) presented as strategy capillary‐rich Specifically, in‐air microfluidics used produce microtissues composed cell‐laden microgels ultrahigh throughput, which can be photoannealed...
There is an increasing clinical need to develop novel biomaterials that combine regenerative and biocidal properties. In this work, we present the preparation of silver/silica-based glassy bioactive (ABG) compositions via a facile, fast (20 h), low temperature (80 °C) approach their characterization. The fabrication process included synthesis glass (BG) particles followed by surface modification with silver nanoparticles. microstructural features ABG samples before after exposure simulated...
Abstract Myocardial infarction (MI) is a significant cardiovascular disease that restricts blood flow, resulting in massive cell death and leading to stiff noncontractile fibrotic scar tissue formation. Recently, sustained oxygen release the MI area has shown regeneration ability; however, improving its therapeutic efficiency for regenerative medicine remains challenging. Here, combinatorial strategy cardiac repair by developing cardioprotective oxygenating hybrid hydrogels locally sustain...
There is an increasing clinical need to develop novel biomaterials that combine regenerative and biocidal properties. In this work, we present the preparation of silver /silica based glassy bioactive (ABG) compositions via a facile, fast (20h), low temperature (80 °C) approach their characterization. The fabrication process included synthesis glass (BG) particles followed by surface modification with nanoparticles. microstructural features ABG samples before after exposure simulated...
Embedded Bioprinting In article number 2204609 by Jeroen Leijten and co-workers, liquid-in-liquid printing of low viscous solutions is enabled the novel use aqueous two-phase systems. Use allows for cytocompatible biofabrication embedded sacrificial strands with an exceptionally large resolution range. The nature bio-ink also direct intricate, interconnected, perfusable networks within 3D structures.
Abstract Cardiac fibrosis occurs following insults to the myocardium and is characterized by abnormal accumulation of non-compliant extracellular matrix (ECM), which compromises cardiomyocyte contractile activity eventually leads heart failure. This phenomenon driven differentiation cardiac fibroblasts (cFbs) into myofibroblasts results in changes ECM biochemical, structural mechanical properties. The lack predictive vitro models has so far hampered search for innovative treatments. Here, we...
Silk-Based Hydrogels In article number 2312261, Su Ryon Shin and co-workers present that the local delivery of oxygen a chemoattractant stem cells via injectable, mechanically robust, tissue-adhesive silk-based hybrid hydrogels alleviated ischemia induced host cell homing at myocardial infarction area, leading to decreased fibrotic scar formation improved cardiac functional recovery.
Mechanotransduction is widely used to guide cell fate in hydrogels. Traditionally, hydrogels contain adhesive ligands that dynamically bond with cells stimulate biochemical signalling axis such as YAP-TAZ. However, the molecular toolbox achieve mechanotransduction has remained virtually limited non-covalent bonds, which limits our ability program engineered living matter. Here, we demonstrate on-cell chemistry can be leveraged covalently tether biomaterials directly onto cells, and reveal...
Abstract Mechanotransduction is widely used to guide cell fate in hydrogels. Traditionally, hydrogels contain adhesive ligands that dynamically bond with cells stimulate biochemical signaling axes such as YAP‐TAZ. However, the molecular toolbox achieve mechanotransduction remains virtually limited non‐covalent bonds, which limits ability program engineered living matter. Here, it demonstrated on‐cell chemistry can be leveraged covalently tether biomaterials directly onto cells, reveal via...