A5000464068- Cannabis and Cannabinoid Research
- Pharmacology and Obesity Treatment
- Pain Mechanisms and Treatments
- Pharmacological Receptor Mechanisms and Effects
Stony Brook University
2017
Background Fatty-acid-binding proteins (FABPs) are intracellular carriers for endocannabinoids, N-acylethanolamines, and related lipids. Previous work indicates that systemically administered FABP5 inhibitors produce analgesia in models of inflammatory pain. It is currently not known whether FABP exert their effects through peripheral or central mechanisms. Here, we examined distribution dorsal root ganglia spinal cord the analgesic peripherally centrally inhibitors. Results...
Metabolism of the endocannabinoid 2-arachidonoylglycerol (2-AG) yields arachidonic acid (AA), precursor to proalgesic eicosanoids including prostaglandin E2 (PGE2). Diacylglycerol lipase β (DAGLβ) is an enzyme that synthesizes 2-AG and its inhibition reduces eicosanoid levels produces antinociceptive effects in models inflammatory pain. Here we test whether DAGLβ a model postoperative pain.Rats were administered selective inhibitor KT109 or vehicle underwent plantar incision. Postsurgical...