A5021801634- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Diagnosis and treatment of tuberculosis
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders
- Pregnancy and Medication Impact
- Tuberculosis Research and Epidemiology
- Liver Diseases and Immunity
- Diverticular Disease and Complications
- Travel-related health issues
- Biosimilars and Bioanalytical Methods
- Mycobacterium research and diagnosis
- Salmonella and Campylobacter epidemiology
- Biotin and Related Studies
- Gastrointestinal motility and disorders
- Hepatitis Viruses Studies and Epidemiology
- Renal Diseases and Glomerulopathies
- Pelvic floor disorders treatments
- Autoimmune Bullous Skin Diseases
- Engineering Technology and Methodologies
- Pharmaceutical Economics and Policy
- Systemic Lupus Erythematosus Research
- Health Systems, Economic Evaluations, Quality of Life
- Muscle activation and electromyography studies
Tampere University
2017-2025
Tampere University Hospital
2017-2025
Finnair (Finland)
1991
University of Jyväskylä
1990
The Epi-IBD cohort is a prospective population-based inception of unselected patients with inflammatory bowel disease from 29 European centres covering background population almost 10 million people. aim this study was to assess the 5-year outcome and course Crohn's (CD).Patients were followed up prospectively time diagnosis, including collection their clinical data, demographics, activity, medical therapy, surgery, cancers deaths. Associations between outcomes multiple covariates analysed...
Few population-based cohort studies have assessed the disease course of ulcerative colitis [UC] in era biological therapy and widespread use immunomodulators. The aim this study was to assess 5-year outcome patients with UC Epi-IBD cohort.In a prospective, inception unselected UC, were followed up from time their diagnosis, which included collection clinical data, demographics, activity, medical therapy, rates surgery, cancers, deaths. Associations between outcomes multiple covariates...
The incidence of inflammatory bowel disease [IBD] is stabilising in many Western countries. Some still show increasing incidence. Our objective was to determine the latest trends IBD and prevalence Finland compare these among different age groups between geographical areas.We used nationwide registry Social Insurance Institute identify new cases during period 2000-2020. Crude, age-specific, age-standardised rates were calculated. Prevalence estimated using valid reimbursements from same...
The etiology of travelers' diarrhea was studied in 579 adult Finnish tourists participating two packaged tours to Morocco the winter (n = 233) and fall 346) 1989. A research team accompanied travelers, a laboratory for enteric pathogens established Agadir. At least one pathogen found 62% 60 cases 58% 111 fall. Multiple were less often (8%) than (21%, P < .05). Campylobacter strains leading cause winter, alone or with other 28% (but only 7% fall), whereas enterotoxigenic Escherichia coli...
Anaemia is an important complication of inflammatory bowel disease [IBD]. The aim this study was to determine the prevalence anaemia and practice screening during first year following diagnosis, in a European prospective population-based inception cohort.Newly diagnosed IBD patients were included followed prospectively for 1 29 one Australian centre. Clinical data including demographics, medical therapy, surgery blood samples collected. defined according World Health Organization criteria.A...
Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there a growing body of evidence that links to certain aspects IBD such as activity and quality life, data on its prevalence how it varies across phenotype, smoking status treatment groups are still missing.Patients diagnosed between 2010 2011 were recruited. Demographic serum levels collected. Variance was then assessed different groups, life scores.A total 238 (55.9% male) included. Overall,...
Dermatitis herpetiformis (DH) is an extraintestinal manifestation of celiac disease causing itchy, blistering rash. Granular IgA deposits in the skin are pathognomonic for DH, and treatment choice a lifelong gluten-free diet (GFD). Preliminary evidence suggests that there patients with DH who redevelop gluten tolerance after adherence to GFD treatment. To evaluate this, we performed 12-month challenge small-bowel mucosal biopsy samples 19 had adhered mean 23 years. Prechallenge was negative...
The lack of scientific evidence regarding the effectiveness 5-aminosalicylate in patients with Crohn's disease is sharp contrast to its widespread use clinical practice.The aim study was investigate as well course a subgroup who were treated maintenance monotherapy during first year disease.In European community-based inception cohort, 488 followed from time their diagnosis. Information on data, demographics, activity, medical therapy and rates surgery, cancers deaths collected...
Therapy with two concomitant biologicals targeting different inflammatory pathways has emerged as a new therapy option for treatment refractory bowel disease (IBD). Data on the efficacy and safety of dual biological (DBT) are scarce investigated in this study.Data all patients treated combination four Finnish tertiary centres were collected analysed. Remission was assessed by physician basis biomarkers, endoscopic evaluation alleviation symptoms.A total 16 22 trials DBT included. Fifteen had...
Abstract Background The repertoire of biological medication for Crohn’s disease (CD) has expanded in the past two decades. impacts these new therapies on surgery rates are still under investigation. Our aim was to analyse newly diagnosed CD patients era all age groups. Methods Newly were collected from registry Social Insurance Institution Finland and data surgeries Finnish Institute Health Welfare. Patients stratified according diagnosis year availability three groups: 2000-2006 (infliximab...
Abstract Background The Epi-IBD cohort is a prospective European population-based of 1,508 patients diagnosed in 2010 and 2011 with inflammatory bowel disease (IBD) according to Copenhagen criteria centres across 17 countries. study aims describe treatment strategies, course prognosis IBD unclassified (IBDU) Europe. Methods Patients IBDU were defined as not fulfilling the diagnostic Crohn’s (CD) or ulcerative colitis (UC), but still required related monitoring. They followed prospectively...
Abstract Background The effect of biological medication on colectomies is still unclear. Our aim was to determine colectomy risk in newly diagnosed Finnish ulcerative colitis (UC) patients and compare the prebiological era. Methods We used registry Social Insurance Institution Finland find UC patients. Data were collected from Institute for Health Welfare. Patients stratified according diagnosis year availability three groups: 2000-2005 (prebiological), 2006-2012 (only infliximab available)...
Abstract Background and Aims The risk of colectomy in patients with ulcerative colitis (UC) has decreased since the 20th century. Our aim was to determine newly diagnosed Finnish UC compare prebiological biological era. Methods We used registry Social Insurance Institution Finland find colectomies were collected from Institute for Health Welfare. stratified according year diagnosis into three groups: 2000-05 (prebiological), 2006-12 2013-20. Results identified 32,108 2,195 performed on them....
The Epi-IBD cohort is a population-based inception of patients with inflammatory bowel disease from 22 European centres. aim was to assess the 10-year course ulcerative colitis (UC) across Europe. Patients were followed prospectively time diagnosis in 2010 and 2011, uniform collection data end 2020. Associations between covariates colectomy, progression extensive hospitalisation analysed separately by multivariable Cox regression analyses propensity score-matched sub-population address...
A definitive diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) is not always possible, and a proportion patients will be diagnosed as inflammatory bowel unclassified (IBDU). The aim the study was to investigate prognosis initially with IBDU course during following 5 years.The Epi-IBD prospective population-based cohort 1289 IBD in centers across Europe. Clinical data were captured prospectively throughout follow-up period.Overall, 476 (37%) CD, 701 (54%) UC, 112 (9%) IBDU. During...
There are no good data in the literature on prevalence of inflammatory bowel disease (IBD) patients with kidney and we do not know whether IBD affects course or if type is an influential factor. The aim this study was to evaluate among who have undergone renal biopsies due clinical indications elucidate presence influences patient outcomes.We collected retrospective concomitant diseases, especially IBD, from adult undergoing biopsy for any indication between 2000 2012 at Tampere University...
Patients undergoing restorative proctocolectomy have often suffered from active ulcerative colitis which should be remembered when assessing quality of life after operation. The aim this study was to explore health-related in those with poor or good pouch function and compare that patients inactive the general population.Altogether, 282 were investigated. control group comprised 408 local register. Generic 15D disease-specific inflammatory bowel disease questionnaire instruments used....
Background and aims Every fifth patient with ulcerative colitis (UC) experiences severe acute flare at some point in the course of disease. Corticosteroids (Cs) remain treatment choice flare. Data on efficacy first intravenous Cs long-term prognosis UC are scarce were investigated here.Materials methods All episodes patients admitted to Tampere University Hospital treated between January 2007 2016 identified from records reviewed. The risks for colectomy continuous use evaluated. Predictive...
Background: The EpiCom-cohort is a European prospective population-based cohort of unselected, uniformly diagnosed patients with inflammatory bowel disease (IBD) in 2010 centres from Western and Eastern countries. aims at describing differences occurrence, treatment strategies, course prognosis within Europe. Methods: Patients were followed each 3rd month for the first year after diagnosis then according to treating physician 2–5th follow-up. Clinical data on surgery, hospitalizations...
Background and aims The early outcomes of ulcerative colitis (UC) after rescue therapy with cyclosporine A (CyA) are well known. Published data on the safety this treatment in perioperative use long-term prognosis scarce investigated here.Methods All UC patients treated CyA Tampere University Hospital between 2009 2018 were reviewed from patient records.Results total 182 included median follow-up 3.8 (range 0-13) years. Of all patients, 139 (76%) responded to CyA. quarter responders achieved...
Immunomodulators have both been shown to improve the disease course in IBD patients: however, literature remains inconsistent. The aim of study was investigate impact treatment with immunomodulators and biological therapy on prognosis patients diagnosed Crohn's (CD) from diagnosis during first 5 years follow-up. Epi-IBD cohort is a prospective population-based 1289 unselected, uniformly 2010 centres Western Eastern European countries. Clinical data were captured prospectively throughout...