A5081721612- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Acute Lymphoblastic Leukemia research
- Biosimilars and Bioanalytical Methods
- Autoimmune and Inflammatory Disorders
- Anorectal Disease Treatments and Outcomes
- Pregnancy and Medication Impact
- Gastric Cancer Management and Outcomes
- Pharmaceutical studies and practices
- Colorectal and Anal Carcinomas
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Surgical Treatments
- Liver Diseases and Immunity
- Diagnosis and treatment of tuberculosis
- Celiac Disease Research and Management
- Colorectal Cancer Treatments and Studies
- Salivary Gland Disorders and Functions
- Digestive system and related health
- Intestinal Malrotation and Obstruction Disorders
- Gastrointestinal motility and disorders
- Mycobacterium research and diagnosis
- Pelvic floor disorders treatments
Hvidovre Hospital
2020-2025
Copenhagen University Hospital
2021-2025
Amager Hospital
2024-2025
University of Copenhagen
2020-2024
Gentofte Hospital
2020-2024
Rigshospitalet
2024
Perianal Crohn's disease [CD] places a considerable burden on patients' quality of life and is complex to treat. Despite its impact high frequency, few studies have investigated the incidence course perianal CD. The aim this study was assess CD in adult patients throughout 19-year period.The cohort comprised all individuals aged 18 years or older who were diagnosed with Denmark between January 1, 1997, December 31, 2015, according National Patient Registry [NPR].A total 1812 [19%] out 9739...
Familial adenomatous polyposis (FAP) is a hereditary disorder that predisposes patients to colorectal cancer (CRC). Prophylactic colectomy has greatly reduced the risk of CRC. However, new associations between FAP and other cancers have subsequently emerged. In this study, we assessed specific primary secondary among with compared matched controls.
Paediatric-onset and elderly-onset inflammatory bowel disease (IBD) present unique treatment challenges.
Abstract Background and Aims Few studies have assessed the contemporary patterns of disease activity in patients with inflammatory bowel [IBD]. We aimed to describe their long-term outcomes. Methods All Danish individuals IBD between 1995 2018 were identified using information about IBD-related hospitalizations, surgeries redeemed prescriptions. The for 5- 10-year periods assessed. Results In incident Crohn’s [CD], severe occurred year diagnosis 80% patients; ulcerative colitis [UC] this...
Despite advances in the medical treatment of Crohn's disease [CD], many patients will still need bowel resections and face subsequent risk recurrence re-resection. We describe contemporary re-resection rates identify disease-modifying factors for conducted a retrospective, population-based, individual patient-level data cohort study covering 47.4% Danish population, including all CD who underwent primary resection between 2010 2020. Among 631 resected patients, 24.5% second resection, 5.3%...
Abstract Background Perianal Crohn's disease (CD) is characterised by fistulae and/or abscesses in the anal region and leads to significant morbidity. We aimed estimate incidence describe course of perianal paediatric-onset CD patients (<18 years at diagnosis). Methods In a nationwide registry-based cohort study, we identified all incident with Denmark from 1980 2018. followed until emigration, death, or December 31, 2022, recorded cumulative based on data National Patient Registry....
Abstract Background Despite a growing array of medical treatment options, resection rates for Crohn’s disease (CD) have decreased over time, while re-resection remained stable at approximately one-third in historical cohorts. This study aimed to assess 30-day postoperative outcomes and complication following primary bowel CD patients. Methods encompassed all patients undergoing Eastern Denmark from 2010 2020 (46% the Danish population, n=2,730,000). Clinical characteristics, surgical...
Abstract Background Due to the increasing prevalence of inflammatory bowel diseases (IBD), an ageing population and increased risk cancer associated with IBD, number patients diagnosed before or while having their IBD is increasing. We aimed describe treatment a prior malignant diagnosis relative without. Methods Danish national registers were used identify all incident Crohn’s disease (CD) Ulcerative Colitis (UC) in Denmark, exposure drugs surgeries, status, between 1996-2022. Cox...
Abstract Background The Epi-IBD cohort is a prospective European population-based of 1,508 patients diagnosed in 2010 and 2011 with inflammatory bowel disease (IBD) according to Copenhagen criteria centres across 17 countries. study aims describe treatment strategies, course prognosis IBD unclassified (IBDU) Europe. Methods Patients IBDU were defined as not fulfilling the diagnostic Crohn’s (CD) or ulcerative colitis (UC), but still required related monitoring. They followed prospectively...
Abstract Background Crohn's disease (CD) is a chronic inflammatory condition that can lead to irreversible intestinal damage. Fibrosis, caused by imbalanced extracellular matrix (ECM) remodeling, difficult manage, as current anti-inflammatory treatments do not prevent or reverse these processes. ECM fragments released during remodeling may serve biomarkers for transmural activity and fibrosis burden. This study evaluated the correlation of serum C3M, PRO-C3, PRO-C16 levels their potential...
Abstract Background and Aims Crohn's disease (CD) is characterized by progressive intestinal transmural damage, including fibrosis strictures, which impair quality of life require surgical intervention. No anti-stricture therapies are available, no accurate biomarkers have been validated allowing prediction strictures. Collagen fragments synthesis remodeling show potential as markers activity. This study aimed to evaluate serum collagen for their accuracy in differentiating between stenosing...
The Epi-IBD cohort is a population-based inception of patients with inflammatory bowel disease from 22 European centres. aim was to assess the 10-year course ulcerative colitis (UC) across Europe. Patients were followed prospectively time diagnosis in 2010 and 2011, uniform collection data end 2020. Associations between covariates colectomy, progression extensive hospitalisation analysed separately by multivariable Cox regression analyses propensity score-matched sub-population address...
Abstract Background and Aims Inflammatory bowel diseases [IBD] are heterogeneous in the frequency severity of their flare-ups. We aimed to describe disease activity patterns a Danish nationwide paediatric IBD cohort. Methods Paediatric patients [<18 years at diagnosis] with Crohn’s [pCD] or ulcerative colitis [pUC] study period from 1996 2018 were identified national registers. Disease [severe, moderate-to-mild, remission] was assessed diagnosis according medications prescribed,...
INTRODUCTION: Familial adenomatous polyposis (FAP) is an autosomal, dominantly inherited disorder that predisposes to colorectal cancer. An increased risk of cancer may affect mental health, but the magnitude this effect remains unknown. We assessed psychosocial functioning, including educational level attained and psychiatric comorbidity, patients with FAP by comparing them matched nonexposed individuals. METHODS: All Danish diagnosed before April 2021 were identified in Polyposis Register...
Abstract Background The rate of having a resection for patients with Crohn's disease (CD) have decreased over decades, while the rates re-resections seem to been stable around 1/3 in historic cohorts. Re-resection might be influenced by targeted therapies. We aimed investigate re-resection and risk recurrence contemporary cohort effect medical treatment on these parameters. Methods This population-based included all CD undergoing primary intestinal between 2010 2020 Eastern Denmark,...
The influence of concomitant prednisolone on clinical outcomes and safety in infliximab-treated ulcerative colitis (UC) patients is unknown.
Background & AimsThiopurine therapy is a cornerstone in the treatment of inflammatory bowel disease (IBD). We aimed to assess effect thiopurines on cancer risk IBD according drug exposure and age.MethodsDanish national registers were used identify incident patients, drugs, status cancers, 1996 2018. Cox regressions compare risks non-IBD individuals patients' cumulative association first cancer, excluding non-melanoma skin cancer.ResultsWe followed 43,419 patients with for median 8.2 years...
Introduction: Familial adenomatous polyposis (FAP) is caused by pathogenic variants in the APC gene. FAP usually categorized according to phenotype: classical (CFAP) and attenuated (AFAP); latter considered have a milder disease course. We aimed assess risk of overall specific cancers CFAP AFAP patients compared matched, non-exposed individuals. Methods: All known Danish were classified as either or assigned four The cancers, mortality analyzed. Results: analysis included 311 patients, 134...
Abstract Background Biological treatment failure is common in patients with ulcerative colitis (UC), but the predictive value of baseline histological activity unknown. Aims We aimed to investigate associations between and outcomes after biological UC. Methods Adult biological-naïve UC (n = 150) were followed prospectively during treatment. Histological was assessed using Nancy Index Geboes score. Endoscopic Mayo Subscore (MES). Associations multivariable models. histological, endoscopic,...
Small bowel strictures are a common complication in Crohn's disease. Endoscopic balloon dilation (EBD) is an emerging therapeutic approach that minimally invasive and helps to preserve the bowel. The aim of this study was describe use EBD adult disease patients with small strictures.This nationwide cohort comprised individuals ≥18 years old, diagnosed Denmark between 1 January 1997 31 December 2015, according National Patient Registry (NPR).The consisted 9737 incident were followed for...