A5082697920- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Colorectal Cancer Surgical Treatments
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Diverticular Disease and Complications
- Eosinophilic Esophagitis
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Mycobacterium research and diagnosis
- Autoimmune and Inflammatory Disorders
- Cancer Cells and Metastasis
- Diagnosis and treatment of tuberculosis
- Adolescent and Pediatric Healthcare
- Colorectal and Anal Carcinomas
- Celiac Disease Research and Management
- IL-33, ST2, and ILC Pathways
- Digestive system and related health
- Pancreatitis Pathology and Treatment
- Esophageal Cancer Research and Treatment
- Extracellular vesicles in disease
- Immunodeficiency and Autoimmune Disorders
University of Copenhagen
2016-2025
Gentofte Hospital
2016-2025
Herlev Hospital
2015-2024
Copenhagen University Hospital
2005-2024
KU Leuven
2016
Zealand University Hospital
2016
International Centre of Insect Physiology and Ecology
2006
Hvidovre Hospital
2004
Glostrup Hospital
1998
Schools of Visual Arts, The Royal Danish Academy of Fine Arts
1989
A continuous increase in the incidence of inflammatory bowel disease (IBD), Crohn's (CD), ulcerative colitis (UC), and indeterminate (IC) has been suggested. Since Denmark provides excellent conditions for epidemiological research, we aimed to describe contemporary IBD rates patient characteristics Copenhagen County City.All patients diagnosed with during 2003-2005 were followed prospectively. Demographic clinical characteristics, such as extent, extraintestinal manifestations, smoking...
It remains uncertain whether the increasing incidence of inflammatory bowel disease (IBD) during last decades has been accompanied by an alteration in presentation, course, and prognosis disease. To answer this question, 3 consecutive population-based IBD cohorts from Copenhagen, Denmark (1962-2005), were assessed evaluated.Phenotype, initial use medications, cumulative surgery rate, standardized ratio colorectal cancer (CRC), mortality (SMR) compared cohorts, which had a total 641 patients...
OBJECTIVES Cumulative 10-yr relapse rates in ulcerative colitis (UC) of 70% to almost 100% have been reported regional studies. The aim this study was determine the rate UC a European population-based cohort 10 yr after diagnosis and identify factors that may influence risk relapse. METHODS From 1991 1993, 771 patients with from seven countries Israel were prospectively included inception followed for yr. A defined as an increase UC-related symptoms leading changes medical treatment or...
Inflammatory bowel disease (IBD) often affects patients in their fertile age. The aim of this study was to describe pregnancy outcome a European cohort IBD patients. As data are limited regarding the effect on course, our second objective investigate whether influences course and phenotype patients.In patients, 10-yr follow-up performed by scrutinizing patient files approaching with questionnaire. comprised 1,125 whom 543 were women. Data from 173 female ulcerative colitis (UC) 93 Crohn's...
Background Immune-related adverse events due to immune checkpoint inhibitors (ICIs) are not always effectively treated using glucocorticoids and it may negatively affect the antitumor efficacy of ICIs. Interventional studies alternatives lacking. We examined whether interleukin-6 blockade by tocilizumab reduced ICI-induced colitis arthritis. Patients methods with solid cancer experiencing Common Terminology Criteria for Adverse Events (CTCAE v5.0) grade >1 colitis/diarrhea (n=9),...
To evaluate the impact of eHealth on disease activity, need for hospital contacts, and medical adherence in children adolescents with inflammatory bowel (IBD). Furthermore, to assess eHealth's influence school attendance quality life (QoL).Patients IBD, 10 17 years attending a public university hospital, were prospectively randomized 2-year open label case-controlled intervention. The eHealth-group used web-application young.constant-care.com (YCC) monthly basis case flare-ups, seen at one...
Background Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) has shown remarkable results in malignant melanoma (MM), while studies on the potential other cancer diagnoses are sparse. Further, prospect of using checkpoint inhibitors (CPIs) to support TIL production and remains be explored. Study design TIL-based ACT CPIs was evaluated a clinical phase I/II trial. Ipilimumab (3 mg/kg) administered prior tumor resection nivolumab mg/kg, every 2 weeks ×4) relation infusion....
The intestinal epithelium ensures uptake of vital nutrients and acts as a barrier between luminal contents the underlying immune system. In inflammatory bowel diseases, such ulcerative colitis (UC), this is compromised, patients experience debilitating symptoms. Here, we perform single-cell RNA profiling epithelial cells outline patterns cell fate decisions in healthy individuals UC patients. We demonstrate that hierarchical behavior are altered identify unique cellular states associated...
To individualize timing of infliximab (IFX) treatment in children and adolescents with inflammatory bowel disease (IBD) using a patient-managed eHealth program.Patients IBD, 10 to 17 years old, treated IFX were prospectively included. Starting 4 weeks after their last infusion, patients reported weekly symptom score provided stool sample for fecal calprotectin analysis. Based on scores results, the program calculated total inflammation burden that determined next infusion (4-12 wk previous...
Inflammatory bowel disease (IBD) is a chronic inflammatory condition driven by diverse genetic and nongenetic programs that converge to disrupt immune homeostasis in the intestine. We have reported that, murine intestinal epithelium with telomere dysfunction, DNA damage-induced activation of ataxia-telangiectasia mutated (ATM) results ATM-mediated phosphorylation YAP1 transcriptional coactivator, which turn up-regulates pro-IL-18, pivotal regulator IBD pathogenesis. Moreover, individuals...
The aetiology of inflammatory bowel disease (IBD) is unknown, but it has become evident that genetic factors are involved in susceptibility. Studies have suggested a north–south gradient the incidence IBD, raising question whether this difference caused by heterogeneity. We aimed to investigate prevalence polymorphisms CARD15 and TLR4 occurrence anti-Saccharomyces cerevisiae (ASCA) antineutrophil cytoplasmic antibodies (pANCA) European population-based IBD cohort. Individuals from incident...
Objective. To give a general outline of 10-year clinical follow-up study population-based European cohort inflammatory bowel disease (IBD) patients and to present the first results in terms outcome parameters risk factors. Materials methods. A newly, prospectively, diagnosed cases was initiated between 1991 1993. The 2201 with IBD (706 had Crohn's (CD), 1379 ulcerative colitis (UC) 116 indeterminate colitis) originated from 20 different areas 11 countries Israel. For this cohort, electronic...
OBJECTIVES A Danish cohort of twins with inflammatory bowel disease (IBD), Crohn's (CD) and ulcerative colitis (UC), has previously been collected. The aim the present study was to reassess this in order compare clinical characteristics concordant versus discordant twin pairs, test zygosity genetically, follow-up on concordance, examine NOD2/CARD15 genetic status. METHODS is one two population-based cohorts worldwide consists 103 pairs. After median 13 yr follow-up, all were contacted...
<b>Background:</b> Population based studies have revealed varying mortality for patients with ulcerative colitis but most described from limited geographical areas who were diagnosed before 1990. <b>Aims:</b> To assess overall in a European cohort of colitis, 10 years after diagnosis, and to investigate national related across Europe. <b>Methods:</b> Mortality diagnosis was recorded prospective European-wide population 1991–1993 nine centres seven countries. Expected calculated the sex, age...