A5059668224- Cancer Cells and Metastasis
- Growth Hormone and Insulin-like Growth Factors
- Childhood Cancer Survivors' Quality of Life
- Hair Growth and Disorders
- Pluripotent Stem Cells Research
- Inflammatory Bowel Disease
- Skin Protection and Aging
- Digestive system and related health
- Single-cell and spatial transcriptomics
- Hippo pathway signaling and YAP/TAZ
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- RNA Research and Splicing
- Kruppel-like factors research
- Cellular Mechanics and Interactions
- Renal and related cancers
- Epigenetics and DNA Methylation
- Congenital heart defects research
- Cancer and Skin Lesions
- Lymphatic System and Diseases
- Circadian rhythm and melatonin
- T-cell and B-cell Immunology
- melanin and skin pigmentation
- Wound Healing and Treatments
University of Copenhagen
2016-2025
Novo Nordisk Foundation
2021-2025
MRC Centre for Regenerative Medicine
2014-2016
University of Edinburgh
2014-2016
Medical Research Council
2014
Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs poorly understood. Here, we show a previously unidentified subpopulation, EpCam+UEA1−Ly-51+PLET1+MHC class IIhi, which comprises <0.5% of TECs, contains bipotent TEC progenitors can efficiently generate both cortical (c) and medullary (m) TECs. No other population tested in this study activity. We demonstrate persistence PLET1+Ly-51+ TEC-derived 9 months vivo,...
The intestinal epithelium ensures uptake of vital nutrients and acts as a barrier between luminal contents the underlying immune system. In inflammatory bowel diseases, such ulcerative colitis (UC), this is compromised, patients experience debilitating symptoms. Here, we perform single-cell RNA profiling epithelial cells outline patterns cell fate decisions in healthy individuals UC patients. We demonstrate that hierarchical behavior are altered identify unique cellular states associated...
Thymus function depends on the epithelial compartment of thymic stroma. Cortical cells (cTECs) regulate T cell lineage commitment and positive selection, while medullary (m) TECs impose central tolerance repertoire. During thymus organogenesis, these functionally distinct sub-lineages are thought to arise from a common progenitor (TEPC). The mechanisms controlling cTEC mTEC production TEPC not however understood. Here, we show that emergence earliest lineage-restricted progenitors requires...
Normal thymus function reflects interactions between developing T-cells and several thymic stroma cell types. Within the stroma, key functions reside in distinct cortical medullary epithelial (TEC) It has been demonstrated that, during organogenesis, all TECs can be derived from a common progenitor (TEPC). The properties of this are thus interest. Differentiation both cTEC mTEC depends on epithelial-specific transcription factor FOXN1, although formation TEPC which TEC lineage originates...
Summary The intestinal epithelium forms a barrier to the lumen and ensures uptake of vital nutrients. During inflammatory diseases, such as ulcerative colitis (UC), this is compromised. Here, we perform single-cell RNA sequencing (scRNA-seq) epithelial cells outline patterns cell fate decisions in healthy individuals patients with UC. We demonstrate that lineage biased progenitors are major sources normal tissue replenishment, behavior profoundly altered furthermore identify unique...
Abstract Epithelial cells are highly dynamic and can rapidly adapt their behavior in response to tissue perturbations increasing demands. However, the processes that finely control these responses and, particularly, mechanisms ensure correct switch from normal homeostasis largely unknown. Here we explore changes cell happening at interface between postnatal development epithelium of mouse esophagus, as a physiological model exemplifying rapid but controlled growth transition. Single RNA...
Abstract Thymus function depends on the epithelial compartment of thymic stroma. Cortical cells (cTECs) regulate T cell lineage commitment and positive selection, while medullary (m) TECs impose central tolerance repertoire. During thymus organogenesis, these functionally distinct sub-lineages are thought to arise from a common progenitor (TEPC). The mechanisms controlling cTEC mTEC production TEPC not however understood. Here, we show that emergence earliest lineage-restricted progenitors...