A5087819909- Stress Responses and Cortisol
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Memory and Neural Mechanisms
- Regulation of Appetite and Obesity
- Receptor Mechanisms and Signaling
- Pain Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Biochemical effects in animals
- Treatment of Major Depression
Ardabil University of Medical Sciences
2020-2023
Abstract A survey of the literature indicates that developmental disruptions in serotonin (5‐HT) levels can influence brain development and function. To best our knowledge, so far, there are a few studies about effects period 5‐HT depletion on cognition behavior adult male female rats. Therefore, present study, we examined postnatal days (PND 10–20) administration para‐chlorophenylalanine (PCPA, 100 mg/kg, s.c) synthesis inhibitor, anxiety‐related behaviors, pain sensitivity, short‐term...
Exposure to enriched environment (EE) has been indicated enhance cognitive functions, hippocampal neural plasticity, neurogenesis, long-term potentiation, and levels of the brain-derived neurotrophic factor (BDNF) in laboratory animals. Also, studies on sex-dependent effects exposure EE during adolescence adult functions are less. This is important because beneficial may be predominant stage. Therefore, present study was designed compare (PND21-PND60) novel objective recognition memory...
Serotonin (5-HT) is an essential neurotransmitter for the refined organization of cerebral cortex. Studies have suggested that altered serotonin signaling contributes to cognitive impairment and psychiatric disorders. However, exact role this on development hippocampal neurons not recognized. Here we aimed examine effects para-chlorophenylalanine (PCPA; 100 mg/kg/daily, s.c. during postnatal days 10-20), a reversible inhibitor 5-HT synthesis, level prefrontal We also focused morphology in...
Abstract Background Fluoxetine (FLX) is widely prescribed as an antidepressant medicine in the juvenile population. Objectives Although some adverse effects of FLX have been reported adults, present study aimed to investigate side treatment during adolescence on cardiac and hepatic systems. Methods Male female rats were gavaged with (5 mg/kg/day) postnatal days (PND) 21 PND 60. Following treatment, blood samples collected enzymes evaluated. The specimens liver heart animals subjected...
The neurotransmitter serotonin (5-HT) is one of the most important modulators neural circuitry and has a critical role in development functions. Previous studies indicated that changes serotonergic system signaling early life critically impact mental health, behavior, morphology hippocampal neurons, cognitive functions across lifespan. enriched environment (EE) beneficial effects on behavior developmental period life, but its impacts impairments behavioral following postnatal depletion are...
The neurotransmitter serotonin (5-HT) has a critical role in neural development and functions. Previous studies indicated that changes serotonergic system signaling early life critically impact mental health, behavior, brain function across the span. Therefore, present study was aimed to evaluate influences of enriched environment (EE) housing (Postnatal day: PND21-60) following postnatal (PND 10–20) depletion by para-chlorophenylalanine (PCPA, 100mg/kg, s.c) administration on...