A5101854864- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Gas Sensing Nanomaterials and Sensors
- Advanced Photocatalysis Techniques
- Covalent Organic Framework Applications
- Chemical Synthesis and Reactions
- Nuclear Materials and Properties
- Cardiomyopathy and Myosin Studies
- Genetics and Neurodevelopmental Disorders
- Bacterial Genetics and Biotechnology
- Nanomaterials for catalytic reactions
- Circular RNAs in diseases
- MXene and MAX Phase Materials
- Bacillus and Francisella bacterial research
- Iron oxide chemistry and applications
- MicroRNA in disease regulation
- Adsorption and biosorption for pollutant removal
- High-Temperature Coating Behaviors
- Orthopaedic implants and arthroplasty
- Insect and Pesticide Research
- Intermetallics and Advanced Alloy Properties
- RNA Interference and Gene Delivery
- Electrocatalysts for Energy Conversion
- Magnesium Alloys: Properties and Applications
Central South University
2005-2025
Hunan Cancer Hospital
2022-2025
Xiangya Hospital Central South University
2024
University of Science and Technology Beijing
2022-2023
Huaiyin Institute of Technology
2023
Peking University
2013
Angiogenesis is a significant character of lung adenocarcinoma (LUAD) and an important reason leading to high mortality rates LUAD patients. However, the molecular mechanisms lncRNAs regulating angiogenesis in have not been fully elucidated. Here we show lncRNA chromatin-associated RNA 10 (CAR10) was upregulated tumor tissue patients with enhanced metastasis. Mechanistically, CAR10 could bind Lactate Dehydrogenase A (LDHA) protein regulate phosphorylation acetylation LDHA increase...
Abstract Long noncoding RNAs (lncRNA) are a class of non‐coding greater than 200 bp in length with limited peptide‐coding function. The transcription LINC00152 is derived from chromosome 2p11.2. Many studies prove that influences the progression various tumors via promoting tumor cells malignant phenotype, chemoresistance, and immune escape. regulated by multiple factors DNA hypomethylation. In addition, participates regulation complex molecular signaling networks through epigenetic...
Abstract Lung adenocarcinoma (LUAD) is one of the main causes cancer-related mortality, with a strong tendency to metastasize early. Transforming growth factor-β (TGF-β) signaling powerful regulator promote metastasis LUAD. Here, we screened long non-coding RNAs (lncRNAs) responsive TGF-β and highly expressed in LUAD cells, finally obtained our master molecular LINC00152. We proved that promoted transcription LINC00152 through classical TGF-β/SMAD3 pathway maintained its stability...
Herein, commercially pure titanium parts (CP‐Ti) are fabricated successfully by laser powder bed fusion using cost‐effective ball milling (BM) near‐spherical powder. The hardness, microstructure, wear, and corrosion performances of BM‐Ti investigated systemically. microstructure the sample consists α ′ phase. Compared with gas‐atomized (GA) spherical powder, exhibits higher hardness (354 HV vs 240 HV) due to grain refinement. Owing formation a denser oxide film finger gain, resistance than...
Increasing evidence suggests that microRNAs' (miRNAs) abnormal expression is one of the main factors chemotherapy resistance in various cancers. However, role miRNAs lung adenocarcinoma (LUAD) to cisplatin still unclear. In this study, we analyzed a microarray dataset investigate related LUAD. The LUAD tissues and cell lines was detected using real-time quantitative polymerase chain reaction (RT-qPCR). Special AT-Rich Sequence-Binding Protein 2 (SATB2) RT-qPCR Western blot. Cell...
Zinc Finger Nucleases (ZFNs), famous for their ability to precisely and efficiently modify specific genomic loci, have been employed in numerous transgenic model organism cell constructions. Here we employ the ZFNs technology, with homologous recombination (HR), construct sequence-specific Amyloid Precursor Protein (APP) knock-in cells. With use of ZFNs, established APP knock lines gene-modification efficiencies about 7%. We electroporated DNA fragment containing promoter protein coding...
A novel and cost-effective approach was successfully developed for synthesizing high-performance magnetic zeolite 4A (MZ) using kaolinite red mud as raw materials via one-step combined activation-reduction subsequent hydrothermal synthesis. The concurrent reduction of hematite (Fe2O3) in to Fe3O4 during the thermal activation eliminated need a distinct process, thereby streamlining synthesis maximizing efficiency. resulting product comprised highly crystalline encapsulating particles derived...
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The oxidation resistance of the TNM alloy (Ti-44Al-4Nb-1.5Mo (B, Y) (at. %)) coated with/without 8YSZ/NiCoCrAlY thermal barrier coating (TBC) was conducted through cyclic at 950 °C. formation mechanism oxide scale, interface interdiffusion mechanism, and evolution law growth (TGO) were systematically investigated. Results show that weight gains TBC are 2.45 mg/cm 2 6.98 , respectively. Ti-Al-N layer (Nb, Mo)-rich near surface play a role in blocking internal diffusion air external metal...
The photogenerated hole transfer from the bulk to surface is highly valued in rational design of advanced photoanodes. However, electrons FTO substrate has a vital influence on separation behaviors charges as well, which would regulate photoelectrochemical (PEC) performance photoanodes turn. Herein, W-TiO2/Ti-Fe2O3 heterojunction was fabricated for first time by inserting W-TiO2 electron layer between Ti-Fe2O3 photoanode and substrate. Benefitting unique transport channel W-TiO2, could...