A5101747429- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Immune cells in cancer
- Esophageal Cancer Research and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
- RNA Research and Splicing
- IL-33, ST2, and ILC Pathways
- Epigenetics and DNA Methylation
- Tannin, Tannase and Anticancer Activities
- Ophthalmology and Visual Impairment Studies
- Ferroptosis and cancer prognosis
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Bone and Dental Protein Studies
- Diet, Metabolism, and Disease
- Sesquiterpenes and Asteraceae Studies
Hunan Cancer Hospital
2017-2025
Central South University
2015-2025
Guangdong Province Women and Children Hospital
2019
Xuzhou Medical College
2011-2013
Second People’s Hospital of Huai’an
2011-2013
Abstract To investigate the potential mechanisms underlying neutrophil extracellular traps (NETs) confer ferroptosis resistance and CD8(+) T cell inhibition in lung adenocarcinoma (LUAD). By intravenous injection of LLC cells into tail vein, a LUAD mouse model was created. Phorbol‐12‐myristate‐13‐acetate (PMA) stimulated neutrophils to facilitate NETs formation combined with inhibitor DNase I explore mechanism on proliferation, migration, resistance, activity. CitH3, myeloperoxidase (MPO),...
Abstract Background Lung cancer is one of the most common malignant tumors threatening human health. The aim this study was to investigate function miR‐21‐5p in lung progression. Methods We analyzed expression levels tissues and cell lines. qRT‐PCR MTT assays were performed after transfection with mimic, inhibitor negative control into cells. Results Luciferase reporter showed directly target SMAD7. significantly suppressed proliferation, invasion migration. found that SMAD7 upregulated...
Abstract Background The impact of neoadjuvant chemoimmunotherapy on pulmonary resection and related outcomes had been poorly reported in previous studies. present study aims to clarify the efficacy safety chemoimmunotherapy, intraoperative difficulty following surgery, comparison with chemotherapy alone non‐small cell lung cancer (NSCLC). Methods Patients newly diagnosed clinical stages IB–IIIB(T3‐4N2) NSCLC, received + PD‐1 inhibitors (PD‐1 Chemo group) or (Chemo followed by surgery between...
Purpose To evaluate the accuracy of modern intraocular lens (IOL) power calculation formulas in eyes with previous myopic laser vision correction (LVC), and to assess impact axial length (AL) on formula performance. Methods A total 108 were included, 52 AL less than 28 mm group 56 or greater group. Refractive prediction errors (RPEs) compared among nine post-LVC formulas: Haigis-TK, Haigis-TK CMAL (incorporating Cooke-modified [CMAL]), PEARL-DGS, Hoffer-QST TK, LISA Barrett True-K EVO...
Th17 cells and IL-17 participate in airway neutrophil infiltration characteristics the pathogenesis of severe asthma. Methyl-CpG binding domain protein 2 (MBD2) expression increased CD4+ T peripheral blood samples asthma patients. However, little is known about that epigenetic regulation MBD2 both immunological experimental cell differentiation. Here, we established a neutrophil-predominant model, which was characterized by hyperresponsiveness (AHR), BALF granulocyte (NEU) increase, higher...
T helper 17 (Th17) cells have proven to be crucial in the pathogenesis of neutrophils-dominant asthma. Hypoxia inducible factor-1α (HIF-1α) is involved allergic responses Our previous studies indicated that Methtyl-CpG binding domain protein 2 (MBD2) expression was increased asthma patients. The aim present study understand how MBD2 interacts with HIF-1α regulate Th17 cell differentiation and IL-17 asthma.A mouse model established using female C57BL/6 mice investigate regulation flow...
Long noncoding RNAs (lncRNAs) have been shown to play important roles in human cancers, including esophageal squamous cell carcinoma (ESCC). We previously demonstrated that a novel lncRNA, lnc-ABCA12-3, was overexpressed ESCC tissues. However, the exact function of lnc-ABCA12-3 is unknown. In current study, we aimed evaluate expression and explore potential mechanism migration, invasion, proliferation. showed upregulated tumor tissues lines. The increased positively associated with advanced...
Abstract Background Recently, long non-coding RNAs (lncRNAs) have been reported to be involved in regulating chemo-resistance of NSCLC, however, the role lncRNA SNHG14 DDP-resistance NSCLC remains unexplored. Methods Relative expression SNHG14, HOXB13 and miR-133a DDP-resistant A549 (A549/DDP) cell its parental were measured using qRT-PCR. Cell proliferation viability indicated A549/DDP was estimated via CCK-8 colony formation experiments. cycle apoptosis analyzed through flow cytometry....
Background: N6-methyladenosine (m6A) is the most abundant modification in eukaryotic mRNA. However, its role non-small cell lung cancer (NSCLC) has not been completely elucidated.
Objectives Neoadjuvant chemoimmunotherapy is the optimal choice in treatment of NSCLC; however, number therapeutic cycles remains unclear. The primary aim this study was to determine neoadjuvant NSCLC. Methods This a real-world clinical analysis that included patients who received followed by surgery from January 2020 August 2022. Patients were divided into two groups based on cycles: 2-cycle group and 3-4-cycles group. endpoint major pathological response (MPR) rate. Results A total 251...
Parthenolide (PT), the effective active ingredient of medicinal plant, feverfew (Tanacetum parthenium), has been used as an anti-inflammatory drug due to its involvement in inhibition NF-кB pathway. Moreover, recent studies have demonstrated anti-tumor effect PT several cancers. However, on esophageal carcinoma remains unclear date. In this study, we examined inhibitory effects and underlying mechanism action human squamous cell (ESCC) cells - Eca109 KYSE-510.The proliferation ability...
Neutrophilic asthma (NA) is associated with a severe disease course and poor response to corticosteroids. The present study aimed compare the effects of various concentrations house dust mite (HDM) allergens, ovalbumin (OVA), major egg allergen, lipopolysaccharide (LPS) in combination on onset NA. Female C57BL/6 mice were grouped according random number table intranasally sensitized HDM/LPS/OVA extracts days 0, 1 2 study. In group 1, received 50 µg HDM + OVA 15 LPS, 100 3 LPS those 4 while...
Abstract Esophageal cancer (EC) is a serious malignancy and that the fifth leading cause of cancer-related death worldwide. squamous cell carcinoma (ESCC) main subtype EC in China. In recent years, long non-coding RNAs (lncRNAs) have demonstrated to be novel tumor-associated regulatory factors. However, functions mechanisms lncRNAs ESCC not been fully understood. this study, we attempted construct Genome-wide expression profiles their potential ESCC. By using microarray, found total 2,366...
Background: Previously, we first identified the human tripartite motifcontaining protein 45 (TRIM45) acts as a novel transcriptional repressor in mitogenactivated kinase (MAPK) signaling pathway. After that, inhibitory role of TRIM45 development tumor was gradually unveiled. However, function tumorigenesis lung cancer has not been characterized. Methods and Results: In this study, found that up-regulated earlystage non-small-cell (NSCLC) tissues. Overexpression cells induces G1 arrest...
Increasing evidence suggests that microRNAs' (miRNAs) abnormal expression is one of the main factors chemotherapy resistance in various cancers. However, role miRNAs lung adenocarcinoma (LUAD) to cisplatin still unclear. In this study, we analyzed a microarray dataset investigate related LUAD. The LUAD tissues and cell lines was detected using real-time quantitative polymerase chain reaction (RT-qPCR). Special AT-Rich Sequence-Binding Protein 2 (SATB2) RT-qPCR Western blot. Cell...
Abnormal activation of the classical Wnt pathway has been reported in non-small-cell lung cancer (NSCLC) previously. Pygo family genes, core regulators Wnt/β-catenin signaling, were also to be involved tumorigenesis. However, role homolog Pygo1 human remains unclear. In current study, we demonstrated an association increased expression with consistent high nuclear β-catenin signals across pathological tissue samples early-stage NSCLC. Overexpression cells resulted enhanced G1/S cell phase...
Abstract Non‐small cell lung cancer (NSCLC) imposes a significant economic burden on patients and society due to its low overall cure survival rates. Tumour‐associated macrophages (TAM) affect tumour development may be novel therapeutic target for cancer. We collected NSCLC tumour‐adjacent tissue samples. Compared with the tissues, Activation Transcription Factor 3 (ATF3) Colony Stimulating 1 (CSF‐1) were increased in tissues. Levels of ATF3 CSF‐1 identified different lines (HBE, A549,...
EGFR mutation has been detected in more than half of non-small cell lung cancer (NSCLC) patients Asia. Lung is the main cause malignant tumor-related death worldwide. Although distant metastases often occurs with advanced NSCLC, uterine cervical metastasis rare. Here, we report a case EGFR-mutated adenocarcinoma metastasis. A 63-year-old female known was found to have abnormal vaginal bleeding during osimertinib follow-up visits. Immunohistochemical (IHC) staining and next-generation...