A5037605762- Cardiac electrophysiology and arrhythmias
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical Practices and Patient Outcomes
- Pharmacy and Medical Practices
- Potassium and Related Disorders
- Ion channel regulation and function
- Pharmacological Effects and Toxicity Studies
- Heart Failure Treatment and Management
- Mast cells and histamine
- Inflammatory mediators and NSAID effects
- Microscopic Colitis
- Drug Transport and Resistance Mechanisms
- Synthesis of β-Lactam Compounds
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- ECG Monitoring and Analysis
- Neuroendocrine regulation and behavior
- Immune Cell Function and Interaction
- Pharmacology and Obesity Treatment
- Psoriasis: Treatment and Pathogenesis
- Bone health and osteoporosis research
- Lung Cancer Treatments and Mutations
- Intensive Care Unit Cognitive Disorders
- Coronary Interventions and Diagnostics
- Diet and metabolism studies
- Inflammatory Bowel Disease
Oita University
1993-2022
Meiji Pharmaceutical University
2011-2021
Musashino University
2016
Seirei Social Welfare Community
2012
Japan Organization of Occupational Health and Safety
2012
National Hospital Organization
2010
Seoul National University Hospital
2010
Tohoku University
2010
University of Cincinnati
2007
Eculizumab given bi-weekly is widely recommended for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). We undertook a retrospective analysis on medical records 763 dosings 14 PNH patients to investigate whether threshold would exist in dosing intervals associated with breakthrough hemolysis. identified 12 events hemolysis 4 patients. Multivariate logistic regression and receiver operating characteristics (ROC) revealed significant association between increased risk prolonged 17...
ABSTRACT Apremilast is a phosphodiesterase 4 inhibitor approved for moderate to severe psoriasis in Japan. significantly improved Physician's Global Assessment (PGA) and Dermatology Life Quality Index (DLQI) both at 6 12 months previously published primary post‐surveillance study. Here, we performed post hoc analysis of the surveillance data evaluate patient characteristics, effectiveness, safety among patients who continued apremilast months. The PMS included 992 patients, whom 646...
Teicoplanin is a glycopeptide antibiotic used for the treatment of MRSA infection. An initial loading dose 400 mg every 12 hours three doses standard dosing regimen. This study aimed to assess whether this regimen was appropriate based on pharmacokinetic/pharmacodynamic (PK/PD) analyses in Japanese patients.We conducted population pharmacokinetic (PPK) analysis teicoplanin by NONMEM using serum drug concentrations obtained from 116 patients with PD analyzed model assuming that variability...
Heavy alcohol drinking is implicated in osteoporosis. Although abstinence rapidly followed by a restoration of osteoblastic activity, little known about the contributions alcohol-related factors or effectiveness lifestyle modification program (LMP) on bone density.We conducted study 138 male alcoholic patients to investigate whether history and concurrent were associated with density calcaneus. A 2.5-months LMP an institutionalized setting was completed 20 them, its effect density, serum...
Human papillomavirus (HPV) vaccines have been shown to be effective for the eradication of HPV and prevention cervical cancer. However, number women who receive vaccinations has decreased over last several years in Japan, due concerns about adverse reactions associated with vaccines. We evaluated safety three types separately young difference risk between other by conducting a meta-analysis. Primary literature was retrieved from MEDLINE, Cochrane Central Register Controlled Trials, Japana...
Dynamic involvement of hypothalamic histamine in ingestive behavior and thermogenesis induced by interleukin-1 beta (IL-1 beta) was examined rats. Intraperitoneal injection 0.12 nmol/rat IL-1 decreased food water intake elevated body temperature. However, depletion neuronal intraperitoneal 160 mumol/rat alpha-fluoromethylhistidine, a suicide inhibitor histidine decarboxylase (HDC), attenuated the suppressive effect on intake, facilitated drinking, enhanced elevating rectal increased turnover...
Hyperphosphatemia is one of the common complications in patients undergoing hemodialysis. Although calcium carbonate (CaC) often used to control serum inorganic phosphorus level dialysis patients, co-administration gastric acid reducers (ARs) may interfere with phosphate binding effect CaC. We performed a retrospective medical chart review study whether ARs attenuate hypophosphatemic CaC hemodialysis.One hundred and eight chronic hemodialysis receiving either alone or concomitant (proton...
Patients admitted in rehabilitation wards are usually older than those general wards. Since elderly patients suffer from multiple co-morbidities thus showing a variety of symptoms, they often at risk polypharmacy. In the present retrospective observational study, we aimed to search for clinical characteristics who were associated with factors influencing number drugs discharge. One hundred and twenty-four (aged ≥65 years) Setagaya Memorial Hospital between April September either 2013 2014...
The melanocortin system is a critical pathway in the regulation of energy balance. In this study, we analyzed peripheral effects synthetic agonist melanotan-II (MT-II) rodents fed low-fat or high-fat diet. MT-II-treated diet-induced obese (DIO) mice lost weight and body fat, whereas low-fat-fed maintained their original weight. Specifically, MT-II treatment led to general reduction both visceral subcutaneous adipose tissue high-fat-fed compared with Vehicle (ad libitum) controls....
Appropriate prescription of dabigatran etexilate methanesulfonate (JAN) is more complicated than assumed, because there are totally 10 items contraindications and instructions for dosage reduction depending on patients' characteristics. We aimed to study whether the routine audit first-time prescriptions performed by pharmacists effective in improving quality prescription.A retrospective re-audit was all issued at Kitahara International Hospital, Tokyo between March 2011 February 2014,...
Medications with anticholinergic or sedative effects induce impaired cognitive and physical performances. The aim of this study was to evaluate the associations drug burden recovery function activities daily living in patients admitted a Japanese rehabilitation hospital after cerebrovascular accidents.We retrospectively reviewed medical records aged 18 years older who had undergone inpatient program for disease Nerima Ken-ikukai Hospital. Patients did not complete because acute unexpected...
Clinical pharmacists have a challenging task when answering patients' question about whether they can take specific drugs with grapefruit juice (GFJ) without risk of drug interaction. To identify the most practicable method for predicting clinically relevant changes in plasma concentrations orally administered caused by ingestion GFJ, we compared predictive performance three methods using data obtained from literature.We undertook systematic search interactions associated GFJ MEDLINE and...
Brugada syndrome (BrS) is a rare sodium channelopathy typically seen in middle-aged, Southeast Asian males conferring high risks of cardiac sudden death. Loss-of-function mutations SCN5A encoding the alpha-subunit channels may account partially for its etiology. We aimed to study whether beta-subunits channel (SCN1B and SCN2B) would also be associated with abnormal excitation BrS.85 Japanese patients suspected have BrS undertook diagnostic challenge test blocker, pilsicainide. Genetic...
Phenobarbital is well tolerated and effective for controlling agitation or preventing convulsion at the end of life. No information available concerning parenteral bioavailability phenobarbital when induration develops injection infusion site. We investigated whether site related to via routes continuous subcutaneous intermittent intramuscular injection.A retrospective analysis was conducted on medical data obtained from 18 patients who received chronic injections prevention convulsions...
Skin rash is a common adverse event induced by epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). Here, we aimed to predict factors that reduce EGFR-TKI-related skin rash.We conducted single-center, retrospective study in patients undergoing treatment for non-small cell lung cancer (NSCLC) with EGFR-TKIs using Cox proportional hazards model.Cox hazard analysis revealed coadministration of non-steroidal anti-inflammatory drug (NSAID) had protective effects against rash....
Population pharmacokinetics (PK) of a sodium channel—blocking antiarrhythmic, pilsicainide, was studied using the nonlinear mixed‐effects modeling technique in 91 patients with cardiac arrhythmias (80 suspected Brugada syndrome [BrS] and 11 atrial fibrillation) who received an intravenous infusion 10 mg drug. pharmacodynamic (PD) analysis also performed effect compartment model. PD responses were assessed by changes electrocardiogram (ECG) pattern (BrS‐like elevation ST‐segment) conduction...