A5069253337- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Biochemical and Molecular Research
- Genomics, phytochemicals, and oxidative stress
- Cancer-related Molecular Pathways
- Glioma Diagnosis and Treatment
- Biochemical Acid Research Studies
- Metabolomics and Mass Spectrometry Studies
- Biopolymer Synthesis and Applications
Universidad de Málaga
2019-2025
Instituto de Investigación Biomédica de Málaga
2019-2025
Most tumor cells can use glutamine (Gln) for energy generation and biosynthetic purposes. Glutaminases (GAs) convert Gln into glutamate ammonium. In humans, GAs are encoded by two genes:
Glutaminase controls the first step in glutaminolysis, impacting bioenergetics, biosynthesis and oxidative stress. Two isoenzymes exist humans, GLS GLS2. is considered prooncogenic overexpressed many tumours, while GLS2 may act as or a tumour suppressor. Glioblastoma cells usually lack they express high GLS. We investigated how expression modifies metabolism of glioblastoma cells, looking for changes that explain GLS2’s potential suppressive role. developed LN-229 stably expressing performed...
A pathway frequently altered in cancer is glutaminolysis where glutaminase (GA) catalyses the main step: deamidation of glutamine to form glutamate and ammonium. There are two types GA isozymes, named GLS GLS2, which differ considerably their expression patterns can even perform opposing roles cancer. correlates with tumor growth proliferation, while GLS2 may function as a context-dependent suppressor. However, both isoenzymes have been described essential molecules handling oxidant stress...
Abstract Background Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: acts as an oncoprotein, while (GAB isoform) has context specific tumour suppressive activity. Some microRNAs (miRNAs) have been implicated progression of tumours, including gliomas. The aim was to investigate the effect GAB expression on both miRNAs oxidative status glioblastoma cells. Methods Microarray profiling miRNA performed GLS-silenced LN229 GAB-transfected T98G human cells their...
A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: deamidation of glutamine to form glutamate and ammonium. There are two types GA isozymes, named GLS GLS2, which differ considerably their expression patterns can even perform opposing roles cancer. correlates with tumor growth proliferation, while GLS2 function a context-dependent suppressor. However, both isoenzymes have been described essential molecules handling oxidant...
Glutaminase controls the first step in glutaminolysis, impacting bioenergetics, biosynthesis and oxidative stress balance. Two isoenzymes exist humans, GLS GLS2. is considered prooncogenic overexpressed many tumours, while GLS2 may act as both or a tumour suppressor. Glioblastoma cells usually lack express high GLS. We aimed to investigate how expression modifies metabolism of glioblastoma cells, looking for changes that explain GLS2’s potential suppressive role. developed LN-229...