A5100671705- Fibroblast Growth Factor Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Speech and Audio Processing
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Speech Recognition and Synthesis
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Crystal structures of chemical compounds
- Enzyme Catalysis and Immobilization
- Phonetics and Phonology Research
- Synthesis and Reactions of Organic Compounds
- Virus-based gene therapy research
- Canadian Identity and History
- Lipid metabolism and biosynthesis
- Molecular Biology Techniques and Applications
- Chemical Synthesis and Analysis
- Dendrimers and Hyperbranched Polymers
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- MXene and MAX Phase Materials
- Neuroscience of respiration and sleep
- Neurogenesis and neuroplasticity mechanisms
University of Hong Kong
2008-2025
Jilin University
2024
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials
2019
Donghua University
2016-2019
State Council of the People's Republic of China
2016-2018
Chinese Academy of Social Sciences
2012-2016
Shanghai University
2014-2015
Chinese Academy of Sciences
2014
Peking University Third Hospital
2014
Peking University
2014
Exosomes are nanovesicles secreted by cells, which play a crucial role in various pathological processes. have shown great promise as tumor biomarkers because of the abundant secretion during formation. The development convenient, efficient, and cost-effective method for simultaneously enriching detecting exosomes is utmost importance both basic research clinical applications. In this study, an aptamer-functionalized magnetic Ti
X-linked Retinitis Pigmentosa (XLRP) accounts for 10–20% of all RP cases, and represents the most severe subtype this disease. Mutations in GTPase Regulator (RPGR) gene are common causes XLRP, accounting over 70–75% XLRP cases. In work, we analyzed exons RPGR with Sanger sequencing seven Chinese families, two these a provisional diagnosis adRP but without male-to-male transmission. Three novel deletions (c.2233_34delAG; c.2236_37delGA c.2403_04delAG) known nonsense mutations (c.851C→G...
Dendrimer-entrapped gold nanoparticles modified with β-cyclodextrin can be synthesized and used as a non-viral vector for enhanced gene delivery applications.
Abstract The effect of fibroblast growth factor‐2 (FGF‐2) on synapse formation was investigated using rat cultured hippocampal neurons. Treatment with FGF‐2 (0.4–10 ng/mL) for 6 days enhanced synaptogenesis these neurons by ∼50%, as determined counting puncta immunostained presynaptic‐ or postsynaptic‐specific proteins. This enhancement statistically significant, and abolished a specific inhibitor mitogen‐activated protein kinase (MAPK). majority expressed FGF receptors (types 1–3)...
Temperature dependences of thermal and elastic properties, such as the Grüneisen parameters, expansion, bulk modulus, heat capacity Ti 2 AlC Cr , are studied by combining first‐principles method lattice dynamic calculation based on quasi‐harmonic model. Experimental expansion coefficient is also measured for comparison. Thermal coefficients show different trends: exhibits anisotropic while shows generally isotropic character. The mechanism explored investigating isotropy or anisotropy...
The folding/unfolding pathway of barnase has been analyzed using a method similar to the classical Brønsted-β approach: Φ-value analysis. Kinetic and equilibrium measurements on over 100 designed mutants have led residue-by-residue description transition state. state responds mutation changes in solvent manner analogous both Hammond anti-Hammond behavior as energy landscape is perturbed. Here, we compare analysis with an explicit structural by molecular dynamics simulations thermal...
The high efficiency and specificity of gene therapy are mainly ascribed to the excellent transfection ability carrier. Non-viral polymer vectors have attracted extensive attention because their low cytotoxicity outstanding genetic loading capacity compared with viral vectors. For safe efficient nuclear acids, here we report a novel delivery system, dendrimer-entrapped gold nanoparticles modified folate-conjugated poly (ethylene glycol) (Au DENPs-PEG-FA), possessing superior than that...
The surface structure of NiO is correlated to observed changes in the band energy, energetic distribution trap states density, charge interface transfer, transport, and as a result p-type DSSC device performance.
Journal Article Investigation of the solution structure chymotrypsin inhibitor 2 using molecular dynamics: comparison to X-ray crystallographic and NMR data Get access Aijun Li, Li Department Medicinal ChemistryUniversity Washington, PO Box 357610, Seattle, WA 98195-7610, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Valerie Daggett 1 1To whom correspondence should be addressed Protein Engineering, Design Selection, Volume 8, Issue 11, November 1995,...
Purpose: To identiy the disease causing mutation in a Chinese family presenting with early-onset cataract and dental anomalies.Materials Methods: A specific Hereditary Eye Disease Enrichment Panel (HEDEP) (personalized customization by MyGenostics, Baltimore, MD) based on targeted exome capture technology was used to collect protein coding regions of 30 associated genes, high throughput sequencing done Illumina HiSeq 2000 platform. The identified variant confirmed Sanger sequencing.Results:...
Density functional theory calculations have been successfully applied to investigate the formation of hydrocarbon radicals and hydrogen transfer pathways related chemical vapor infiltration process based on model molecules phenanthrene, anthra[2,1,9,8-opqra]tetracene, dibenzo[a,ghi]perylene, benzo[uv]naphtho[2,1,8,7-defg]pentaphene, dibenzo[bc,ef]ovalene. The reaction rate constants are calculated within framework Rice-Ramsperger-Kassel-Marcus transition state by use density calculation...
La-deficient La0.77−xCa0.2SrxMnO3 (0 ≤ x 0.1) polycrystalline samples are synthesized using the sol-gel technique. The crystal structures of all single orthorhombic phase with Pbnm space group. Rietveld analysis x-ray diffraction patterns shows that Mn−O−Mn bond angle θMn − O Mn increases whereas Mn−O length dMn decreases monotonically increasing Sr2+ content, which results in a rich overlap between 3d and 2p orbitals leads to systematic increase Curie temperature this compound. It is found...