A5012227218- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Dendrimers and Hyperbranched Polymers
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Advanced Photocatalysis Techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Graphene and Nanomaterials Applications
- Medical Imaging Techniques and Applications
- Immunotherapy and Immune Responses
- Radiopharmaceutical Chemistry and Applications
- Sexual function and dysfunction studies
- Reproductive Health and Contraception
- Adolescent Sexual and Reproductive Health
- Ocular Oncology and Treatments
Wenzhou Medical University
2020-2024
Affiliated Eye Hospital of Wenzhou Medical College
2020-2024
Donghua University
2015-2021
RWTH Aachen University
2021
Shanghai Jiao Tong University
2021
Peking Union Medical College Hospital
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials
2016-2017
State Council of the People's Republic of China
2016
We report the use of arginine-glycine-aspartic (Arg-Gly-Asp, RGD) peptide-modified dendrimer-entrapped gold nanoparticles (Au DENPs) for highly efficient and specific gene delivery to stem cells. In this study, generation 5 poly(amidoamine) dendrimers modified with RGD via a poly(ethylene glycol) (PEG) spacer PEG monomethyl ether were used as templates entrap (AuNPs). The native RGD-modified PEGylated respective well characterized Au DENPs vectors transfect human mesenchymal cells (hMSCs)...
Exploitation of novel hybrid nanomaterials for combinational tumor therapy is challenging. In this work, we synthesized dendrimer-modified MoS2 nanoflakes gene silencing and photothermal (PTT) cancer cells. Hydrothermally were modified with generation 5 (G5) poly(amidoamine) dendrimers partially functionalized lipoic acid via disulfide bond. The formed G5-MoS2 display good colloidal stability superior conversion efficiency stability. With the dendrimer surface amines on their surface, are...
We describe a safe and highly effective non-viral vector system based on β-cyclodextrin (β-CD)-modified dendrimer-entrapped gold nanoparticles (Au DENPs) for improved delivery small interfering RNA (siRNA) to glioblastoma cells. In our approach, we utilized amine-terminated generation 5 poly(amidoamine) dendrimers partially grafted with β-CD as nanoreactor entrap Au NPs. The acquired β-CD-modified DENPs DENPs-β-CD) were complexed two different types of therapeutic siRNA (B-cell...
Multifunctional PEI-entrapped gold nanoparticles modified with RGD peptide <italic>via</italic> a PEG spacer enable efficient therapeutic siRNA delivery to glioblastoma cells.
Aim: To synthesize the arginine-glycine-aspartic (RGD) functionalized dendrimer-entrapped gold nanoparticles (Au DENPs) for siRNA delivery to induce gene silencing of cancer cells in vitro and vivo. Materials & methods: Au DENPs modified with RGD peptide via a polyethylene glycol spacer were used as vector two distinct small interfering RNAs (siRNAs) (VEGFvascular endothelial growth factor B-cell lymphoma/leukemia-2 siRNA), physicochemical properties, cytocompatibility transfection...
Exploring a plasmid DNA (pDNA)/small interfering RNA (siRNA) delivery vector with excellent biocompatibility and high gene transfection efficiency still remains great challenge. In this research, generation 5 (G5) dendrimer-entrapped gold nanoparticles (Au DENPs) partially modified polyethylene glycol monomethyl ether (mPEG) were designed as non-viral pDNA/siRNA vectors. The pDNA that can encode luciferase (Luc) or enhanced green fluorescent protein (EGFP) the Bcl-2 siRNA knockdown...
The striking imbalance between the ever-increasing amount of nanomedicines and low clinical translation products has become focus intense debate. For translation, critical issue is to select appropriate agents combination regimen for targeted diseases, not prepare increasingly complex nanoplatforms. A safe efficient platform, α-tocopheryl succinate (α-TOS) married 2D molybdenum disulfide, was devised by a facile method applied cooperative imaging-guided photothermal-selective chemotherapy...
Abstract This article reports the fabrication of a smart biomimetic enzyme system, which incorporates pH‐responsive chemodynamic therapy (CDT) combined with photothermal (PTT) approach in resolving high recurrence rate deadly cancers. The resulting system comprises copper sulfide (CuS) nanoparticle (NP) cores as Fenton‐like catalysts, and photothermal‐active generation 5 poly(amidoamine) (G5) dendrimer template for entrapment Cu NPs compression glucose oxidase (GOD). GOD is introduced to...
Uveal melanoma (UM) is an ocular cancer predominantly affecting adults, characterized by challenging diagnostic outcomes. This research endeavors to develop innovative multifunctional nanocomposite system sensitive near-infrared (NIR) radiation, serving as both a non-oxygen free-radical generator and photothermal agent. The designed combines azobis isobutyl imidazoline hydrochloride (AIBI) with mesoporous copper sulfide (MCuS) nanoparticles. MCuS harnesses NIR laser energy induce therapy,...
Design of dendrimer-based nanoarchitectures for enhanced gene delivery still remains a great challenge. Here, we report the design core-shell tecto dendrimers using supramolecular assembly approach applications. Firstly, β-cyclodextrin (CD)-modified generation 5 (G5) poly(amidoamine) (PAMAM) (G5-CD) and adamantine (Ad)-modified 3 (G3) PAMAM (G3-Ad) both having amine termini were synthesized. Through recognition CD Ad, G5-CD/Ad-G3 with G5 core G3 shell formed. The formed size 8.4 nm possess...
Dendrimer-entrapped gold nanoparticles modified with β-cyclodextrin can be synthesized and used as a non-viral vector for enhanced gene delivery applications.
This paper aimed to find an effective method destroy cancer cells by targeting breast with natural killer (NK) transfected the human ferritin heavy chain (hFTH1) gene polyethylene glycol (PEG)-modified dendrimerentrapped gold nanoparticles (Au DENPs). In this study, fifth-generation polyamidoamine (G5 PAMAM) dendrimers modified PEG were used as templates entrap transfect hFTH1 into NK cells. Our results revealed that prepared Au DENPs/FTH1 provided high-quality imaging performance...
Development of nanoplatforms for targeted anticancer drug delivery effective tumor therapy still remains challenging in the development nanomedicine. Here, we present a facile method to formulate LAPONITE (LAP) nanodisk-based nanosystem doxorubicin (DOX) folic acid (FA) receptor-overexpressing tumors. In current work, aminated LAP nanodisks were first prepared through silanization, then functionalized with polyethylene glycol-linked FA (PEG-FA) via...
The reports about the effects of sexual attitudes and activities on obstetric outcomes were inconsistent or even contradictory. This study aims to investigate patterns intercourse during pregnancy its impact neonatal outcomes. All participants delivered their babies between September 2016 June 2017 at Peking Union Medical College Hospital (PUMCH). An online questionnaire was sent postpartum women with singleton deliveries least 6 months after deliveries. perinatal outcome data collected by...
Abstract Antibiotic‐resistant bacterial strains are a major cause of disease. They continue to remain challenge in the clinic particularly vision system. For example, infectious endophthalmitis is blind‐causing disease caused by bacteria. A highly efficient synergistic antibacterial treatment that uses photothermal therapeutic with chemo‐antibacterial multifunctional nanocomposite reported. It prepared immobilizing vancomycin onto surface magnetic chitosan‐graphene (VCM‐MCG) composite. An...
We report a new
Abstract Background The striking imbalance between the ever-increasing amount of nanomedicines and low clinical translation products has become focus intense debate. For translation, critical issue is to select appropriate agents combination regimen for targeted diseases, not prepare increasingly complex nanoplatforms. Methods Herein, a safe efficient platform, α-tocopheryl succinate (α-TOS) married 2D molybdenum disulfide, was devised by facile method applied cooperative imaging-guided...