A5026268608- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Photoacoustic and Ultrasonic Imaging
- Advanced Nanomaterials in Catalysis
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Antimicrobial Peptides and Activities
- Inflammasome and immune disorders
- Gold and Silver Nanoparticles Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Dendrimers and Hyperbranched Polymers
- TiO2 Photocatalysis and Solar Cells
- 3D Printing in Biomedical Research
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Photocatalysis Techniques
- Mass Spectrometry Techniques and Applications
- Bone Tissue Engineering Materials
- Peptidase Inhibition and Analysis
- Ultrasound and Cavitation Phenomena
- Immune cells in cancer
- Inhalation and Respiratory Drug Delivery
Huazhong University of Science and Technology
2020-2025
Hubei University
2018-2025
Union Hospital
2020-2025
Ministry of Education
2016
By mimicking the RIBE machinery, we provided an indirect radiotherapy approach based on RT-MP for eradication of MPE in mice.
Photodynamic therapy (PDT) is a clinical cancer treatment modality based on the induction of therapeutic reactive oxygen species (ROS), which can trigger immunogenic cell death (ICD). With aim simultaneously improving both PDT-mediated intracellular ROS production and ICD levels, we designed serum albumin (SA)-coated boehmite ("B"; aluminum hydroxide oxide) organic-inorganic scaffold that could be loaded with chlorin e6 (Ce6), photosensitizer, honey bee venom melittin (MLT) peptide, denoted...
Polypyrrole nanoparticle (PPy) based theranostic agents for magnetic resonance imaging (MRI) guided photothermal therapy (PTT) have received increasing attention in recent years. However, the limitations of cost and biocompability still offer us opportunities to improve these agents. Considering versatile character polydopamine (PDA), PEGylated PPy@Fe3+-chelated PDA nanocomposites (PPDEs) were designed prepared an easy way. PPDE with a uniform core-shell structure could be obtained by...
Inorganic or inorganic-organic hybrid nanomaterials have great potential for applications in the biomedical fields. Biological half-life is an essential pharmacokinetic parameter these materials to function
Schematic illustration of the synthesis SILs and NIR fluorescence imaging guided SF, PDT PTT theranostic nanoplatforms.
Oncolytic virus ablation of tumor cells has the advantages high selectivity, strong immunogenicity, and low side effects. However, recognition clearance oncolytic viruses by immune system are main factors limiting their anti-tumor efficiency. As a highly biosafe modifiable vector, acrylamide can improve long-term circulation viruses. Still, it is limited in its uptake efficiency cells. Herein, we constructed an N-hydroxymethyl acrylamide-b-(N-3-aminopropyl methacrylamide)-b-DMC block...
Angiogenesis is an irreplaceable therapeutic cancer target, where anti-angiogenesis are drugs that limited by their hydrophobicity and low effects.
Pyroptosis is a programmed cell death mediated by gasdermins (GSDMs). The prognostic value of pyroptosis-related genes in different tumor types has been gradually demonstrated recently. However, the impact GSDMs expression glioma remains unclear. Here, we present comprehensive bioinformatic analysis gasdermin family member gene expression, producing model for and creating competing endogenous RNA (ceRNA) network. mRNA profiles clinical information patients were downloaded from TCGA CGGA. A...
Phototherapy has garnered worldwide attention for its minimal invasiveness, controllability, and spatial selectivity in treating cancer. One promising approach involves the use of near-infrared dye IR780, which demonstrates both photodynamic therapy (PDT) photothermal (PTT) effects under 808 nm laser irradiation. However, this hydrophobic dye's toxicity limited tumor targeting ability severely hamper suitability cancer applications. Herein, a biocompatible nanoplatform CoOOH-IR780@BSA...
Magnetic resonance imaging (MRI)-guided photothermal therapy (PTT) has recently attracted tremendous attention.
Abstract Pyroptosis is a programmed cell death process mediated by gasdermins (GSDMs). The prognostic value of pyroptosis-related genes in different tumor types has been gradually demonstrated recently. However, the impact GSDMs expression glioma remains unclear. Here, we present comprehensive bioinformatic analysis gasdermin family member gene expression, producing model for and creating competing endogenous RNA (ceRNA) network. We identify significant association between GSDMD GSDME stage,...