A5076454646- Nitric Oxide and Endothelin Effects
- Cardiovascular Health and Disease Prevention
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Angiogenesis and VEGF in Cancer
- Atherosclerosis and Cardiovascular Diseases
University of Virginia
2022-2024
Thromboembolic events, including myocardial infarction (MI) or stroke, caused by the rupture erosion of unstable atherosclerotic plaques are leading cause death worldwide. Although most mouse models atherosclerosis develop lesions in aorta and carotid arteries, they do not advanced coronary artery lesions. Moreover, undergo spontaneous plaque with MI stroke so at such a low frequency that viable experimental to study late-stage thrombotic events identify novel therapeutic approaches for...
In large conduit arteries, smooth muscle cell elastin produces elastic laminae, while in resistance arteries endothelial derived is the major contributor to internal lamina (IEL). The IEL separates and endothelium contain distinct holes (HIEL) where two types communicate via a structure termed myoendothelial junction (MEJ). MEJ an anatomical hallmark of that pierces through facilitates vasodilation by movement hyperpolarization (EDH) muscle. contrast, dilate nitric oxide (NO) do not MEJs. To...