A5061313592- Parkinson's Disease Mechanisms and Treatments
- Diet and metabolism studies
- Tryptophan and brain disorders
- Gut microbiota and health
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Biochemical effects in animals
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Long-Term Effects of COVID-19
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical and biochemical processes
- Aluminum toxicity and tolerance in plants and animals
- Sleep and Work-Related Fatigue
- COVID-19 Clinical Research Studies
- Date Palm Research Studies
- Renin-Angiotensin System Studies
- Metabolism and Genetic Disorders
- Bioactive natural compounds
- Medicinal Plants and Neuroprotection
JSS Academy of Higher Education and Research
2018-2024
National Institute on Alcohol Abuse and Alcoholism
2022-2024
National Institutes of Health
2022
Mitochondrial aldehyde dehydrogenase-2 (ALDH2) metabolizes acetaldehyde to acetate. People with ALDH2 deficiency and
Polyphenols are shown to protect from or delay the progression of chronic neurodegenerative diseases. Mitochondrial dysfunction plays a key role in pathogenesis Parkinson's disease (PD). This study was aims gain insight into ahydroalcoholic extract cocoa (standardised for epicatechin content) on mitochondrial biogenesis MPP+ intoxicated human neuroblastoma cells (SHSY5Y). The effects PPARγ, PGC1α, Nrf2 and TFAM protein expression membrane potential were evaluated. A pre-exposure decreased...
Mitochondrial dysfunction is a well-established pathological event in Parkinson's disease (PD). Proteins misfolding and its impaired cellular clearance due to altered autophagy/mitophagy/pexophagy contribute PD progression. It has been shown that mitochondria have contact sites with endoplasmic reticulum (ER), peroxisomes lysosomes are involved regulating various physiological processes. In conditions, the crosstalk at initiates alterations intracellular vesicular transport, calcium...
Introduction: Date palm fruits (DFs) are reported to possess antimutagenic, antiviral, antifungal, and anti-inflammatory properties. Effect of date in the management Huntington’s is yet be studied. Methods: The protective effects DF were measured terms superoxide dismutase (SOD) glutathione peroxidase (GPx) activities reduced (rGSH), malondialdehyde (MDA) nitrate/nitrite (NO2/NO3) content cells. Cellular adenosine triphosphate (ATP) was also measured. Cytotoxicity assay revealed that has...
Sleep deprivation (SD) is commonly associated with decreased attention, reduced responsiveness to external stimuli, and impaired locomotor cognitive performances. Strong evidence indicates that SD disrupts neuro-immuno-endocrine system which also linked function. Recently Zebrafish have emerged as a powerful model sharing organizational functional characteristics other vertebrates, providing great translational relevance rapid reliable screening results. In the current study, we examined...
Background: Mitochondrial dysfunction plays a crucial role in Parkinson’s disease (PD) pathogenesis. The present study was undertaken to investigate the effects of Telmisartan (TEL), an angiotensin II type 1 receptor (AT1R) blocker, on mitochondria-specific genes expression mouse model Parkinsonism. Materials and methods: Mice were divided into 5 groups with 6 each; Group I received 0.5% CMC (control) + saline, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (positive control), III &...
Sleep plays a crucial role in metabolic homeostasis thereby influencing health and well-being. It is closely related to the balance of energy metabolism. Physiological, environmental factors affect length quality sleep. As problem sleep disturbance pervasive disturbances are linked changes body fluids. Disturbance affects composition physiology This review summarized provide evidences on alterations major