A5033759468- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- Parkinson's Disease Mechanisms and Treatments
- Aluminum toxicity and tolerance in plants and animals
- Curcumin's Biomedical Applications
- Cholinesterase and Neurodegenerative Diseases
- Genetic Neurodegenerative Diseases
- Natural Antidiabetic Agents Studies
- Nuts composition and effects
- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Tryptophan and brain disorders
- Biochemical and biochemical processes
- Neuroinflammation and Neurodegeneration Mechanisms
- Sirtuins and Resveratrol in Medicine
- Analytical Methods in Pharmaceuticals
- Nerve injury and regeneration
- Diet and metabolism studies
- Plant biochemistry and biosynthesis
- Neuroscience and Neuropharmacology Research
- Ginkgo biloba and Cashew Applications
- Mitochondrial Function and Pathology
- Phytochemicals and Antioxidant Activities
- Retinoids in leukemia and cellular processes
- Tea Polyphenols and Effects
Annamalai University
2014-2024
Madurai Kamaraj University
2022-2023
SRM Institute of Science and Technology
2021
Bharathiar University
2020
Harvard University Press
2016
Sultan Qaboos University
2016
Rotenone a widely used pesticide that inhibits mitochondrial complex I has been to investigate the pathobiology of PD both in vitro and vivo . Studies have shown neurotoxicity rotenone may be related its ability generate reactive oxygen species (ROS), leading neuronal apoptosis. The current study was carried out neuroprotective effects hesperidin, citrus fruit flavanol, against rotenone-induced apoptosis human neuroblastoma SK-N-SH cells. We assessed cell death, membrane potential, ROS...
Deregulation of metal ion homeostasis has been assumed as one the key factors in progression neurodegenerative diseases. Aluminium (Al) believed a major risk factor for cause and Alzheimer's disease (AD). In our lab, we have previously reported that hesperidin, citrus bioflavonoid reversed memory loss caused by aluminium intoxication through attenuating acetylcholine esterase activity expression Amyloid β biosynthesis related markers. Al to oxidative stress associated apoptotic neuronal...
Objective: Mitochondrial dysfunction and oxidative stress-mediated apoptosis plays an important role in various neurodegenerative diseases including Huntington's disease, Parkinson's disease (PD) Alzheimer's (AD). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the most widely used neurotoxin mimics symptoms of PD by inhibiting mitochondrial complex I that stimulates excessive intracellular reactive oxygen species (ROS) finally leads to mitochondrial-dependent apoptosis. Lutein, a...
Emblica officinalis is mentioned as a maharasayana in many Ayurvedic texts and promotes intelligence, memory, freedom from disease, longevity, strength of the senses. The present study has been designed to explore memory-enhancing effect tannoid principles E. (EoT) at biochemical, anatomical, behavioral, molecular levels against aluminum chloride (AlCl3) induced Alzheimer's disease (AD) rats. Aluminum reported have an important role etiology, pathogenesis, development AD.Male Wistar rats...
Vanillin, a phenolic compound, has been reported to offer neuroprotection against experimental Huntington's disease and global ischemia by virtue of its antioxidant, anti-inflammatory, antiapoptotic properties. The present study aims elucidate the underlying neuroprotective mechanism vanillin in rotenone induced neurotoxicity. Cell viability was assessed exposing SH-SY5Y cells various concentrations (5-200 nM) for 24 h. therapeutic effectiveness measured pretreatment at then incubation with...
Alzheimer's disease (AD) is a common neurodegenerative disorder that mainly affects the aged population and characterized by progressive loss of hippocampal cortical neurons, which results in memory cognitive impairments. Trigonella foenum-graecum (fenugreek) has been reported to have hypoglycemic, hypocholesterolemic, hyperinsulinemic anti-diabetic properties. Traditionally, it was used as galactagogue treat anorexia, fever gastritis, gastric ulcers, various nervous disorders. However,...
Alzheimer's disease (AD) is the most common form of dementia, characterized by memory loss, cognitive impairment and personality disorders accompanied diffuse structural abnormalities in brain elderly people. The current investigation explored neuroprotective potential asiatic acid (AA), a natural triterpene Centella asiatica on aluminium chloride (AlCl3) induced rat model AD. Oral administration AlCl3 (100 mg/kg b.w.) for 42 days significantly elevated levels Al, activity acetyl...
Parkinson's disease (PD) is a chronic neurodegenerative disease, manifested due to the loss of dopaminergic neurons, which ultimately leads impaired movement in elderly populations. The pathogenesis PD associated with numerous factors including oxidative stress, mitochondrial dysfunction and apoptosis. There no effective therapy available cure or halt progression this still now. Asiatic acid (AA) triterpene extracted from Centella asiatica has been reported as an antioxidant...
Mitochondrial dysfunction and oxidative stress are the main toxic events leading to dopaminergic neuronal death in Parkinson's disease (PD) identified as vital objective for therapeutic intercession. This study investigated neuro-protective effects of demethoxycurcumin (DMC), a derivative curcumin against rotenone induced neurotoxicity.SH-SY5Y neuroblastoma cells divided into four experimental groups: untreated cells, incubated with (100 nM), treated DMC (50 nM) + alone treated. 24 h after...
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by extracellular plaques containing abnormal Amyloid Beta (Aβ) aggregates, intracellular neurofibrillary tangles hyperphosphorylated tau protein, microglia-dominated neuroinflammation, and impairments in synaptic plasticity underlying cognitive deficits. Therapeutic strategies for the treatment of AD are currently limited. In this study, we investigated effects dietary supplementation 4% pomegranate extract to...
Alzheimer's disease (AD) is the most common form of dementia that mainly affects cognitive functions aged populations. Trigonella foenum-graecum (L.) (fenugreek), a traditionally well utilized medicinal plant ubiquitously used as one main food additive worldwide, known to have numerous beneficial health effects. Fenugreek seed extract could be able inhibit activity acetylcholinesterase (AChE), key enzyme involved in pathogenesis AD, and further shown anti-parkinsonic effect. The present...
Pharmacognosy Magazine,2018,14,53,9-16.DOI:10.4103/pm.pm_113_17Published:February 2018Type:Original ArticleAuthors:Muthu Ramkumar, Srinivasagam Rajasankar, Veerapan Venkatesh Gobi, Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Ranganathan Chidambaram, Saravana Babu and Giles J Guillemin Author(s) affiliations:Muthu Ramkumar1, Rajasankar2, Gobi1, Janakiraman3, Manivasagam3, Thenmozhi3, Essa4, Chidambaram5, Chidambaram6, Guillemin7 1...