A5016670215- Molecular Sensors and Ion Detection
- Microbial Natural Products and Biosynthesis
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Bioactive Compounds and Antitumor Agents
- Analytical Chemistry and Sensors
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- Microbial Metabolism and Applications
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Nanoplatforms for cancer theranostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Electrochemical Analysis and Applications
- Polyamine Metabolism and Applications
- Chemical Synthesis and Analysis
- Radiation Detection and Scintillator Technologies
- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- Genomics and Chromatin Dynamics
- Biochemical and Molecular Research
- Cancer Treatment and Pharmacology
- Carbohydrate Chemistry and Synthesis
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
Institute of Gene Biology
2019-2024
Federal Medical-Biological Agency
2020-2024
Gause Institute of New Antibiotics Russian Academy of Medical Sciences
2019-2022
Russian Cancer Research Center NN Blokhin
2019
This article discusses the design and analysis of a new chemical chemosensor for detecting mercury(II) ions. The is hydrazone made from 4-methylthiazole-5-carbaldehyde fluorescein hydrazide. structure was confirmed using various methods, including nuclear magnetic resonance spectroscopy, infrared spectroscopy with Fourier transformation, mass quantum calculations. sensor's ability in highly selective sensitive discovery Hg2+ ions water demonstrated. detection limit determined to be 0.23 µM....
Gold nanoparticles (GNPs) emerged as promising antitumor radiosensitizers. However, the complex dependence of GNPs radiosensitization on irradiation conditions remains unclear. In present study, we investigated impacts dose rate and photon energy damage pBR322 plasmid DNA exposed to X-rays in presence 12 nm, 15 21 26 nm GNPs. The greatest was observed for sensitizer enhancement ratio (SER) 2.74 ± 0.61 at 200 kVp with 2.4 mg/mL Reduction X-ray tube voltage 150 100 led a smaller effect. We...
Nanoparticles (NPs) with a high atomic number (Z) are promising radiosensitizers for cancer therapy. However, the dependence of their efficacy on irradiation conditions is still unclear. In present work, 11 different metal and oxide NPs (from Cu (ZCu = 29) to Bi2O3 (ZBi 83)) were studied in terms ability enhance absorbed dose combination 237 X-ray spectra generated at 30–300 kVp voltage using various filtration systems anode materials. Among high-Z NP materials, gold was absolute leader by...
Olivomycin A (OA), an antibiotic of the aureolic acid family, interferes with gene transcription upon forming complexes GC-rich regions in DNA minor groove. We demonstrate that mechanism transcriptional deregulation is not limited to OA interaction GC-containing binding sites for factors. Using electrophoretic mobility shift assays and DNAse I footprinting cytomegalovirus (CMV) promoter fragments carrying OA-preferred GC tetrads (CMVwt), we showed specifically islands. Replacement G these...