A5102019802- Rheumatoid Arthritis Research and Therapies
- Bone health and treatments
- Systemic Lupus Erythematosus Research
- Bone and Joint Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- Signaling Pathways in Disease
- Medical Imaging and Pathology Studies
- Cancer and Skin Lesions
- Estrogen and related hormone effects
- Genetics and Neurodevelopmental Disorders
- Ultrasound in Clinical Applications
- Renin-Angiotensin System Studies
- Hip disorders and treatments
- Cancer Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Orthopedic Infections and Treatments
- Nuclear Receptors and Signaling
- Systemic Sclerosis and Related Diseases
- Genetic Associations and Epidemiology
- Spine and Intervertebral Disc Pathology
Hospital General Universitario De Valencia
2023
Karolinska Institutet
2020-2023
Hospital Clínico Universitario de Valencia
2019-2020
Universitat de València
2018-2020
Hospital Del Mar
2001-2017
Parc de Salut
2013-2014
Palmetto Hematology Oncology
2013
Center for Rheumatology
2013
Camilo José Cela University
2012
Sociedad Española de Reumatología
2008
Objective. To estimate the incidence of early arthritis (EA) and RA in adults (>16 yrs) Spain. Methods. Primary care physicians were instructed detection new cases using a checklist. All evaluated at EA units (EAUs) within 15 days detection. ACR criteria for classification assessed every 6 months thereafter. Results. In an area covering 4 342 378 inhabitants over age 16 yrs, 2467 patients referred to EAU, whom 1063 fulfilled (43.1%). After months, 362 criteria. The estimated annual was...
Macroautophagy (hereafter referred to as autophagy) plays a critical role in neuronal function related development and degeneration. Here, we investigated whether autophagy is developmentally regulated the striatum, brain region implicated neurodevelopmental disease. We demonstrate that autophagic flux suppressed during striatal postnatal development, reaching adult levels around day 28 (P28). also find mTOR signaling, key regulator of autophagy, increases same developmental period. further...
Dermoscopy is a useful tool for dermatologists to study melanocytic lesions. Its possible usefulness in the assessment of capillary nailfold morphological changes (capillaroscopy) has recently been advocated.To assess practical utility digital epiluminescence microscopy as capillaroscopic instrument patients with Raynaud phenomenon (RP). To compare sensitivity and specificity rates obtained by those previously reported conventional devices.Fifty-six consecutive primary RP (PRP; n = 5) or...
OBJECTIVE: Extragonadal estrogen biosynthesis is relevant for the regulation of bone metabolism. The aims this paper were: (i) to examine CYP19 (aromatase) gene expression in primary cultures osteoblasts under several hormone and cytokine treatments (ii) study promoter usage these cells. METHODS: Primary were obtained from healthy donors. effects vitamin D other factors on analysed by semiquantitative RT-PCR. Furthermore, alternative different was characterized RESULTS: transcripts detected...
To estimate the efficacy and safety of 5 mg 10 mifepristone for emergency contraception up to 144 hours after unprotected coitus.This double-blind randomized clinical trial was carried out at Eusebio Hernandez Hospital (Havana, Cuba). A total 2,418 women who requested coitus received either or mifepristone. The variables assessing were pregnancies that occurred fraction prevented. Other assessed side effects mifepristone, vaginal bleeding, changes in date following menstruation.There...
To describe the results of different statistical ways addressing radiographic outcome affected by missing data--multiple imputation technique, inverse probability weights and complete case analysis--using data from an observational study.A random sample 96 RA patients was selected for a follow-up study in which radiographs hands feet were scored. Radiographic progression tested comparing change total Sharp-van der Heijde score (TSS) joint erosion (JES) baseline to end second year follow-up....
Objectives: To monitor repair of bone erosions using magnetic resonance imaging (MRI) in patients with rheumatoid arthritis (RA) during etanercept combination therapy.
Abstract To evaluate the incidence of diagnosis Paget's disease bone in Spain, a retrospective study was performed from 1991–1997 four Spanish centers to number diagnosed cases. Information about age, gender, and year admission an estimation reference population with discharges at were registered for each calendar year. The relative diagnostic risk calculated, using 1991 as by Poisson's regression models. percentage males among cases varied 39% 1992 62% 1993 without significant difference...
Objectives To attempt to replicate previous reports that polymorphic variation in the DCP1 gene causes increased susceptibility development of Alzheimer's disease, either on its own or interaction with effects for apolipoprotein E (APOE).Method Subjects older than 65 years age consisting 81 dementia patients diagnosed as having possible probable disease and 68 controls were obtained from Camden, Islington Harlow psychiatric services. genotyped APOE alleles e2, e3 e4, common...
Objectives To attempt to replicate previous reports that polymorphic variation in the DCP1 gene causes increased susceptibility development of Alzheimer's disease, either on its own or interaction with effects for apolipoprotein E (APOE). Method Subjects older than 65 years age consisting 81 dementia patients diagnosed as having possible probable disease and 68 controls were obtained from Camden, Islington Harlow psychiatric services. genotyped APOE alleles e2, e3 e4, common...
Reelin is an extracellular matrix glycoprotein that modulates synaptic function and plasticity, with a crucial role in neuronal migration. Changes the expression of this protein have been reported neurodegenerative diseases, such as Alzheimer's disease (AD). This molecule produced by Cajal-Retzius neurons during development inhibitory adult nervous system. Individuals Down syndrome (DS) present early AD; therefore, we analyzed alterations its receptors murine model for DS Ts65Dn well human...
<h3>Background</h3> Systemic Lupus Erythematosus (SLE) is a chronic, autoimmune disease characterized by acute and chronic inflammation of various tissues the body. Studies have found an increase in bone loss fracture individuals with SLE compared to general population (1). <h3>Objectives</h3> The aim this study was describe prevalence osteopenia - osteoporosis find possible predictors our cohort patients SLE. <h3>Methods</h3> Retrospective, descriptive (ACR 1982 revised criteria) who were...