A5088729686- Nuclear Receptors and Signaling
- Effects and risks of endocrine disrupting chemicals
- Adipose Tissue and Metabolism
- Parasite Biology and Host Interactions
- Genetics, Aging, and Longevity in Model Organisms
- Parkinson's Disease Mechanisms and Treatments
- Amino Acid Enzymes and Metabolism
- Amyotrophic Lateral Sclerosis Research
- Genomics, phytochemicals, and oxidative stress
- Genetics and Neurodevelopmental Disorders
- Peroxisome Proliferator-Activated Receptors
- RNA Research and Splicing
- Neuroscience and Neuropharmacology Research
- Molecular Biology Techniques and Applications
- Spaceflight effects on biology
- Chromosomal and Genetic Variations
- RNA regulation and disease
- Cancer-related gene regulation
- Genetic and Environmental Crop Studies
- TGF-β signaling in diseases
- Epigenetics and DNA Methylation
- Glutathione Transferases and Polymorphisms
- Insect symbiosis and bacterial influences
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
University of Michigan
2023-2024
Southern Research Institute
2021-2022
University of Alabama at Birmingham
2017-2021
University of Illinois Urbana-Champaign
2016-2018
Many studies implicate mitochondrial dysfunction as a key contributor to cell loss in Parkinson disease (PD). Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed deficiency nuclear-encoded genes for respiration, many which are targets the transcription factor estrogen-related receptor gamma (Esrrg/ERRγ). We demonstrate that deletion ERRγ DAergic adult mice was sufficient cause levodopa-responsive PD-like phenotype reductions gene expression and...
Nematodes are considered excellent models for understanding fundamental aspects of neuron function. However, nematodes less frequently used as examining the evolution nervous systems. While habitats and behaviors diverse, neuroanatomy is often highly conserved. A small number nematode species greatly influences our neurobiology. The free-living Caenorhabditis elegans and, to a lesser extent, mammalian gastrointestinal parasite Ascaris suum are, historically, primary sources knowledge...
Both high-fat diets (HFD) and bisphenol A (BPA), an environmental endocrine disruptor, are prevalent in industrialized societies. Previous studies have detected separate effects of BPA HFD; however, none assessed possible interactive effects. Here, pregnant dams consumed 0, 40, or 400 µg BPA/kg/day were fed either a control (CON; 15.8% kcal fat) HFD (45% from gestational day 2 through parturition. The pups individually dosed with postnatal days (P) 1–10, while the continued to consume one...
The success of all plant-parasitic nematodes is dependent on the completion several complex behaviors. lesion nematode Pratylenchus penetrans an economically important parasite a diverse range plant hosts. Unlike cyst and root-knot nematodes, P. moves both within outside host roots can feed from locations. Adult females require insemination by actively moving males for reproduction lay eggs roots. We do not have complete understanding molecular basis these One candidate modulator behaviors...
Abstract TGF-β receptor 3 (TGFβ-R3) or betaglycan, promotes high-affinity binding of (1, 2 and 3) to TGFβ-R1 TGFβ-R2. Additionally, it is also a for bone morphogenic proteins (BMPs) inhibins. Although TGFβ-R3 widely expressed on cells both the innate adaptive immune system, embryonic lethality Tgfbr3 knock-outs has been limitation obtain mechanistic understanding its function in response. We therefore developed Tgfbr3f/fmouse bred with CD4Cre mouse. Remarkably, thymic inactivation had no...
Alzheimer's disease (AD) is a prevalent and costly age-related dementia. Heritable factors account for 58-79% of variation in late-onset AD, but substantial remains age-of-onset, severity, whether those with high-risk genotypes acquire AD. To emulate the diversity seen human populations, we utilized AD-BXD mouse panel. This genetically diverse resource combines AD multiple BXD strains to discover new genetic drivers resilience. By comparing carriers noncarrier littermates, computed novel...
Abstract When next generation sequencing is performed in large batches, there are several stages at which samples can be swapped or mislabeled. It therefore helpful, when possible, to integrate measures into analysis pipelines confirm that match their assigned metadata. Here, we introduce RNA Strain-Match (GitHub: https://github.com/jon-willcox/RNA-strain-match ), a quality control tool developed data the form of sequence alignment files ( i.e . SAM BAM files) corresponding genotype without...
Abstract Background In Alzheimer’s disease (AD), risk factors and clinical progression differ between sexes. Men have lower post‐diagnosis life‐expectancies 1,2 , while women display worsened cognitive decline than men with similar neuropathology 3‐5 or shared genetic 6,7 . Investigation of sex‐specific contributions to AD has largely focused on the X‐chromosome, but emerging evidence also linked somatic Y‐chromosomal instability age‐linked outcomes, including 8‐10 Notably, Y‐chromosome...