A5013757111- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Dietary Effects on Health
- Muscle metabolism and nutrition
- Epigenetics and DNA Methylation
- Phytochemicals and Antioxidant Activities
- Nutrition and Health in Aging
- Natural Antidiabetic Agents Studies
- Lipid metabolism and biosynthesis
- Gut microbiota and health
- Birth, Development, and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Genetics, Aging, and Longevity in Model Organisms
- Childhood Cancer Survivors' Quality of Life
- Liver Disease Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Diet, Metabolism, and Disease
- Effects of Radiation Exposure
- Hematopoietic Stem Cell Transplantation
- Mitochondrial Function and Pathology
- Cardiovascular Disease and Adiposity
- Mesenchymal stem cell research
- Exercise and Physiological Responses
- Metabolomics and Mass Spectrometry Studies
University of Illinois Urbana-Champaign
2016-2025
The Ohio State University Wexner Medical Center
2019-2024
The Ohio State University
2020
Autonomous University of Queretaro
2013-2015
Background: Brown adipose tissue (BAT) is an important for thermogenesis, making it a potential target to decrease the risks of obesity, type 2 diabetes, and cardiovascular disease, recent studies have also identified BAT as endocrine organ. Although has been implicated be protective in this point there are no that identify direct role mediate cardiac function. Methods: To determine on function, we utilized model transplantation. We then performed lipidomics increase lipokine...
Abstract Aging is associated with low‐grade inflammation that increases the risk of infection and disease, yet underlying mechanisms remain unclear. Gut microbiota composition shifts age, harboring microbes varied immunogenic capacities. We hypothesized gut acts as an active driver during aging. Microbiome patterns in aged mice strongly signs bacterial‐induced barrier disruption immune infiltration, including marked increased levels circulating lipopolysaccharide (LPS)‐binding protein (LBP)...
Abstract Regular, moderate exercise modifies the gut microbiome and contributes to human metabolic immune health. The may exert influence on host physiology through microbial production modification of metabolites (xenometabolites); however, this has not been extensively explored. We hypothesized that 6 weeks supervised, aerobic 3×/week (60%–75% heart rate reserve [HRR], 30–60 min) in previously sedentary, lean ( n = 14) obese 10) adults would modify both fecal serum xenometabolome. Serum...
Obesity and its co-morbidities including type 2 diabetes are increasing at epidemic rates in the U.S. worldwide. Brown adipose tissue (BAT) is a potential therapeutic to combat obesity diabetes. Increasing BAT mass by transplantation improves metabolic health rodents, but clinical translation remains challenge. Here, we investigated if of 2-4 million differentiated brown pre-adipocytes from mouse stromal fraction (SVF) or human pluripotent stem cells (hPSCs) could improve health....
Exercise mediates tissue metabolic function through direct and indirect adaptations to acylcarnitine (AC) metabolism, but the exact mechanisms are unclear. We found that circulating medium-chain acylcarnitines (C12-C16) lower in active/endurance trained human subjects compared sedentary controls, this is correlated with elevated cardiorespiratory fitness reduced adiposity. In mice, exercise serum AC increased liver AC, was accompanied by a marked increase expression of genes involved hepatic...
The nutrient sensor farnesoid X receptor (FXR) transcriptionally regulates whole-body lipid and glucose homeostasis. Several studies examined targeting FXR as a modality to treat obesity with varying conflicting results, emphasizing the need study tissue-specific roles of FXR. We show that deletion adipocyte Fxr results in increased hypertrophy suppression several metabolic genes is akin some changes noted high fat diet (HFD)-fed control mice. Moreover, upon challenge, these effects are...
The consumption of cricket (Acheta domesticus, AD) has recently increased due to its high nutritional and bioactive compound contents. However, limited studies have explored the beneficial effects AD consumption. Therefore, we aimed evaluate protective effect a diet supplemented with flour on obesity control complications in an vivo model. chemical profiling showed important protein content, chitin, polyunsaturated fatty acids For study, high-fructose saturated fat (HFFD) was (4% 8%). 8%...
Abstract Background Obesity increases the risk of developing impaired glucose tolerance (IGT) and type 2 diabetes (T2D) after myocardial infarction (MI). Brown adipose tissue (BAT) is important to combat obesity T2D, increasing BAT mass by transplantation improves metabolism cardiac function. The objective this study was determine if had a protective effect on function in high-fat diet (HFD) fed mice subjected mild MI. Methods Male C57BL/6 were HFD for eight weeks then divided into Sham...
Both high-fat diets (HFD) and bisphenol A (BPA), an environmental endocrine disruptor, are prevalent in industrialized societies. Previous studies have detected separate effects of BPA HFD; however, none assessed possible interactive effects. Here, pregnant dams consumed 0, 40, or 400 µg BPA/kg/day were fed either a control (CON; 15.8% kcal fat) HFD (45% from gestational day 2 through parturition. The pups individually dosed with postnatal days (P) 1–10, while the continued to consume one...
The late effects of radiation therapy can have significant consequences for the health and quality life long-term cancer survivors. Radiation induces persistent alterations in hematopoietic stem progenitor cells (HSPC) bone marrow environment; however, how relevant host factors such as obesity exercise differentially regulate HSPC content environment after exposure remains unknown. purpose this investigation was to evaluate combination training modulates their niche sublethal mice.Mice fed...
Abstract Background Atrial fibrillation (AF) is the most common sustained arrhythmia, with growing evidence identifying obesity as an important risk factor for development of AF. Although defective atrial myocyte excitability due to stress-induced remodeling ion channels commonly observed in setting AF, little known about mechanistic link between and Recent studies have identified increased cardiac late sodium current ( I Na,L ) downstream calmodulin-dependent kinase II (CaMKII) activation...
Perinatal exposure to endocrine disrupting chemicals negatively impacts health, but the mechanism by which such toxicants damage long-term reproductive and metabolic function is unknown. Lipid metabolism plays a pivotal role in steroid hormone synthesis as well energy utilization storage; thus, aberrant lipid regulation may contribute phthalate-driven health impairments. In order test this hypothesis, we specifically examined epigenetic disruptions pathways after perinatal phthalate...
That maternal and paternal exercise improve the metabolic health of adult offspring is well established. Tissue serum metabolites play a fundamental role in an organism, but how parental affects tissue has not yet been investigated. Here, male female breeders were fed high-fat diet housed with or without running wheels before breeding (males) during gestation (females). Offspring sedentary chow fed, parents as follows: (Sed), (MatEx), (PatEx), maternal+paternal (Mat+PatEx). Adult from all...
Adipose-derived lipid droplets (LDs) are rich in triacylglycerols (TAGs), which regulate essential cellular processes, such as energy storage. Although TAG accumulation and LD expansion adipocytes occur during obesity, how LDs dynamically package TAGs response to excessive nutrients remains elusive. Here, we found that lipidomes display a remarkable increase acyl chain saturation under calorie-dense diets, turning them conducive close-packing. Using high-resolution X-ray diffraction,...
Obesity-induced inflammation is associated with increased risk for colorectal cancer (CRC). The role of diet and exercise in modulating CRC obesity the potential altered hematopoiesis as a contributor to these effects remain unknown. purpose this study was examine how weight loss induced during induction or without alters initiation its relationship hematopoiesis. Mice consumed either control (CON) high-fat induce obesity. All mice were then placed on azoxymethane (AOM). Following AOM...
Diet induced obesity (DIO), resulting from long-term consumption of a high fat diet, modifies multiple signaling pathways. Wnt pathway is one these response pathways that closely associated with normal growth and maintenance gut epithelia as well inflammatory responses. There are two major types pathways, the canonical non-canonical calcium dependent pathway. The interact each other play significant roles in cell development, stem maintenance, morphogenesis, differentiation, inflammation....