A5101884424- Cancer-related molecular mechanisms research
- Urinary Bladder and Prostate Research
- Urological Disorders and Treatments
- Phytochemicals and Antioxidant Activities
- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Pneumocystis jirovecii pneumonia detection and treatment
- Reconstructive Facial Surgery Techniques
- Pharmacogenetics and Drug Metabolism
- RNA modifications and cancer
- Circular RNAs in diseases
- Pelvic floor disorders treatments
- Lung Cancer Treatments and Mutations
- Pneumonia and Respiratory Infections
- Innovations in Medical Education
- Neuroscience of respiration and sleep
- Antifungal resistance and susceptibility
- Ear Surgery and Otitis Media
- Phytochemistry and Biological Activities
- Fungal Infections and Studies
- Seedling growth and survival studies
- Nanocomposite Films for Food Packaging
- Chemical Reactions and Isotopes
Fudan University
2012-2024
Sun Yat-sen University
1990-2024
Shanghai Xuhui Central Hospital
2022-2024
Xuzhou Medical College
2009-2024
Zhongshan Hospital
2012-2024
The First Affiliated Hospital, Sun Yat-sen University
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Keio University
2021
University of Wisconsin–Madison
1991-2019
Qiqihar Medical University
2017-2019
Abstract Ferroptosis, an iron-dependent regulated cell death mechanism, holds significant promise as a therapeutic strategy in oncology. In the current study, we explored regulatory effects of epigallocatechin gallate (EGCG), prominent polyphenol green tea, on ferroptosis and its potential implications for non-small lung cancer (NSCLC). Treatment NSCLC lines with varying concentrations EGCG resulted notable suppression proliferation, evidenced by reduction Ki67 immunofluorescence staining....
Previous studies have demonstrated that pluripotency-associated transcription factors, such as Oct3/4, Nanog and Sox2, play a crucial role in the development malignant progression of various types tumors. Breast cancer is most frequent among females, being heterogeneous disease, with distinct morphologies, metastatic behavior therapeutic responses. The expression Sox2 3 human breast cell lines, MCF7, T-47D MDA-MB-231, was determined. mRNA determined by reverse polymerase chain reaction...
We have previously shown that in the presence of elevated Smad3, transforming growth factor-β (TGF-β) transforms from an inhibitor to a stimulant vascular smooth muscle cell (SMC) proliferation and intimal hyperplasia (IH). Here we identify novel mechanism through which TGF-β/Smad3 also exacerbates IH by inhibiting SMC apoptosis. found TGF-β treatment led inhibition apoptosis rat SMCs following viral expression Smad3. Conditioned media these cells when applied naive recapitulated this...
Negative feelings, such as anxiety and depression, are common in patients with cancer. Our aim was to investigate the prevalence of malnutrition distress cancer examine relationship between them. We did a cross-sectional study West China hospital, China, using adapted questionnaires derived from Patient-Generated Subjective Global Assessment (PG-SGA), Nutritional Risk Screening 2002 (NRS2002) Distress Thermometer (DT). also focused on factors associated distress. found that psychological...
No AccessJournal of UrologyInvestigative Urology1 Feb 1999FUNCTIONAL ANATOMY OF THE MALE FELINE URETHRA: MORPHOLOGICAL AND PHYSIOLOGICAL CORRELATIONS BAOQING WANG, NARENDRA BHADRA, and WARREN M. GRILL WANGBAOQING WANG More articles by this author , BHADRANARENDRA BHADRA GRILLWARREN View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)61989-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Anatomical...
Moist chilling (cold stratification) is well-known as a simple and effective means of overcoming physiological seed dormancy enhancing germination many temperate tree shrub species. However, the apparent activation intracellular repair mechanisms in non-dormant black spruce ( Picea mariana ) seeds following moist chilling, has not previously been reported. The present contribution records beneficial effects after accelerated ageing (40°C/98% relative humidity) for 3–10 d seeds. This...
Tannins are water soluble polyphenols. Previous studies showed that Agrimonia pilosa Ledeb contains high levels of tannins. In this study, a microwave-assisted extraction (MAE) method was evaluated for the The optimal conditions were as follows: irradiation power 500 W, ratio solvent to material 35 ml/g, temperature 30°C and time 15 min. Under these conditions, yields tannins from A. pilosa ledeb achieved 128.65 mg/g. MAE provided good alternative pilosa ledeb. Key words: Agrimonia...
Agrimoniin, a form of tannin separated from Agrimonia pilosa ledeb, causes cancer cell death through induction apoptosis. The present study was designed to investigate the effects ofagrimoniin on mitochondrial transmembrane potential and reactive oxygen species (ROS) production in human gastric SGC-7901. In addition, concentration intracellular calcium measured by laser confocal scanning microscopy (LCSM). results showed treatment groups significantly lower than that untreatment group. cells...
Intraoperative neurophysiological monitoring (IONM) has proven to help reduce the probability of postoperative neurological deficit for spinal deformity correctional surgeries. However, in rare cases new deficits may still happen. We report a surgical case which patient had paralysis. would like call more reports with as they present difficult clinical cases. A 61-year-old male severe thoracolumbar kyphoscoliosis underwent posterior correction and fusion segmental T10-L5 pedicle screws rods...
Non‑small cell lung cancer (NSCLC) is a primary subtype of that accompanied by high incidence rate and poor prognosis. The treatment for NSCLC chemotherapy, which has low effectiveness toxicity. Thus, novel targeted therapy drawn much attention in recent years. MicroRNAs (miRs) serve important roles multiple types. In the current study, decrease miR‑98‑5p an increase mitogen‑activated protein kinase 3 (MAP4K3) was observed tumor tissues compared with normal tissues. predicted to target...
The purpose of this study was to evaluate antioxidant activities the ethyl acetate soluble fraction (ESF) and butanol (BSF) agrimony acetone extract. ESF BSF were investigated for their by means 2, 2-diphenhyl-1-picrylhydrazyl (DPPH), 2-azino-bis 3-ethylbenzthiazoline-6-sulphonic acid (ABTS), β-carotene-linoleate hydroxyl radical assay. IC50 values 8.76, 7.28, 13.56 1.76 μg/ml, respectively in four assays. Similarly, 9.77, 7.96, 8.61 2.57 μg/ml. present showed that both have more effective...
Acute lung injury (ALI) is a major cause of mortality and morbidity in the clinic. None current pharmacological interventions has achieved detectable benefit. The renin-angiotensin system (RAS) complex humoral essentially involved regulation ALI. In RAS family, angiotensin (Ang)-(1-7) was found to provide protection by counteracting effects Ang II various cardiopulmonary disease models. downstream receptor Ang-(1-7) G protein-coupled (GPCR) Mas. We hypothesize that Ang-(1-7)-Mas pathway...
// Fan 1, 2 , Zhengqiu Zhu 3 Chao Gao Yun Liu 1 Baoqing Wang Ziquan and Jifeng Feng Department of Chemotherapy, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Institute Research, 210009, China The No.2 Hospital Xuzhou University, 221000, Correspondence to: Feng, email: medfjif@sina.com Keywords: lncRNA, lung cancer, prognosis Received: July 06, 2017 Accepted: August 29, Published: September 20, ABSTRACT Many different long non-coding RNAs (lncRNAs) have been reported to be...
Cleft palate is one of the most common maxillofacial birth defects, which can occur alone or accompany with many known deformities. Palatal selves need to complete process vertical growth, elevation, adhesion and fusion in a specific time window embryo development. Any abnormality this will lead cleft palate. Although previous studies have identified molecular networks that regulate location palatal selves, there are still unknown mechanisms for The pathogenesis has not been clarified so...
There is increasing evidence that long non‑coding (lnc)RNA EGFR‑AS1 involved in the development of numerous types cancer, including non‑small‑cell lung cancer (NSCLC). The Cancer Genome Atlas (TCGA) demonstrates highly expressed NSCLC. Downregulation A549 and PC9 NSCLC cells inhibition proliferation, invasion metastasis. present study demonstrated lncRNA was essential for through its function as a competitive endogenous RNA binding to miR‑449a upregulating histone deacetylase 1. In brief, it...