A5084554516- Cellular Mechanics and Interactions
- Lipid Membrane Structure and Behavior
- Cardiomyopathy and Myosin Studies
- Micro and Nano Robotics
- Force Microscopy Techniques and Applications
- Material Dynamics and Properties
- Polymer crystallization and properties
- Rheology and Fluid Dynamics Studies
- 3D Printing in Biomedical Research
- Microtubule and mitosis dynamics
- Advanced Fluorescence Microscopy Techniques
- Slime Mold and Myxomycetes Research
- Food composition and properties
- History of Science and Medicine
- Cell Image Analysis Techniques
- UAV Applications and Optimization
- Adhesion, Friction, and Surface Interactions
- Probiotics and Fermented Foods
- Millimeter-Wave Propagation and Modeling
- Ruminant Nutrition and Digestive Physiology
- Historical Studies on Reproduction, Gender, Health, and Societal Changes
- Historical Psychiatry and Medical Practices
- Telecommunications and Broadcasting Technologies
- Polymer Surface Interaction Studies
- Gene Regulatory Network Analysis
University of Maryland, College Park
2019-2023
Sichuan Agricultural University
2022
University of Kansas
2021
The plasma membrane defines the shape of cell and plays an indispensable role in bridging intra- extracellular environments. Mechanochemical interactions between cytoskeleton are vital for biomechanics mechanosensing. A computational model that comprehensively captures complex, cell-scale cytoskeleton-membrane dynamics is still lacking. In this work, we introduce a triangulated accounts membrane's elastic properties, as well membrane–filament steric interactions. corresponding force-field...
Mechanochemical simulations of actomyosin networks are traditionally based on one-dimensional models actin filaments having zero width. Here, and in the follow up paper (arXiv, DOI 10.48550/arXiv.2203.01284), approaches presented for more efficient modeling that incorporates stretching, shearing, twisting filaments. Our a semiflexible filament with small but finite width is Cosserat theory elastic rods, which allows six degrees freedom at every point filament's backbone. In variational this...
In most eukaryotic cells, actin filaments assemble into a shell-like cortex under the plasma membrane, controlling cellular morphology, mechanics, and signaling. The is highly polymorphic, adopting diverse forms such as ring-like structures found in podosomes, axonal rings, immune synapses. biophysical principles that underlie formation of rings cortices remain unknown. Using molecular simulation platform called MEDYAN, we discovered varying filament treadmilling rate myosin concentration...
To better evaluate the effects of Acremonium cellulase (AC) and previously screened heat-resistant Lactobacillus plantarum 149 (LP149) on lignocellulose degradation, fermentation quality, microbial community during ensiling in humid hot areas, this study used a small-scale system to prepare hybrid elephant grass silage at 30 45°C, respectively. Compared control commercial inoculant (LP), addition AC or strain LP149 decreased contents neutral detergent fiber, acid cellulose increased glucose,...
Abstract The plasma membrane defines the shape of cell and plays an indispensable role in bridging intra- extra-cellular environments. Mechanochemical interactions between cytoskeleton are vital for biomechanics mechanosensing. A computational model that comprehensively captures complex, cell-scale cytoskeleton-membrane dynamics is still lacking. In this work, we introduce a triangulated accounts membrane’s elastic properties, as well membrane-filament steric interactions. corresponding...
Simulating soft matter systems such as the cytoskeleton can enable deep understanding of experimentally observed phenomena. One challenge modeling is realistic description steric repulsion between nearby polymers. Previous models polymeric excluded volume interaction have deficit being non-analytic, computationally expensive, or allowing polymers to erroneously cross each other. A recent solution these issues, implemented in MEDYAN simulation platform, uses analytical expressions obtained...
We present a multi-resolution methodology for modelling F-actin filaments. It provides detailed microscopic information at the level of individual monomers lower computational cost by replacing monomer-based model in parts simulated filament rod-based macroscopic model. In description, G-actin is represented ellipsoids bound surface double helical configuration to form F-actin. The coarser, which described using Cosserat model, as seen preceding paper [arXiv:2112.01480]. illustrated three...
"Intimate communities: wartime healthcare and the birth of modern China, 1937–1945." Women's History Review, 31(2), pp. 346–347
In most eukaryotic cells, actin filaments assemble into a shell-like cortex under the plasma membrane, controlling cellular morphology, mechanics, and signaling. The is highly polymorphic, adopting diverse forms such as ring-like structures found in podosomes, axonal rings, immune synapses. biophysical principles that underlie formation of rings cortices remain unknown. Using molecular simulation platform, called MEDYAN, we discovered varying filament treadmilling rate myosin concentration...
Stress fibers are actomyosin bundles that regulate cellular mechanosensation and force transduction. Interacting with the extracellular matrix through focal adhesion complexes, stress highly dynamic structures regulated by myosin motors crosslinking proteins. Under external mechanical stimuli such as tensile forces, fiber remodels its architecture to adapt cues, displaying properties of viscoelastic materials. How structural remodeling is related generation contractile not well understood....
Unmanned aerial vehicle (UAV)-to-ground (U2G) channel models play a pivotal role for reliable communications between UAV and ground terminal. This paper proposes three-dimensional (3D) non-stationary hybrid model including both large-scale small-scale fading U2G multiple-input-multiple-output (MIMO) channels. Distinctive characteristics under scenarios, i.e., 3D trajectory posture of UAV, fuselage scattering effect (FSE), variation (PVF), are incorporated into the proposed model. The...
Mechanochemical simulations of actomyosin networks are traditionally based on one-dimensional models actin filaments having zero width. Here, and in the follow up paper, approaches presented for more efficient modelling which incorporates stretching, bending, shearing twisting filaments. Our a semi-flexible filament with small but finite width is Cosserat theory elastic rods, allows six degrees freedom at every point filament's backbone. In variational this discrete set parameters used to...