A5064904642- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Maternal and Perinatal Health Interventions
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal and fetal healthcare
- Pregnancy-related medical research
- Medical Malpractice and Liability Issues
- Patient Safety and Medication Errors
- Blood Coagulation and Thrombosis Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Fetal and Pediatric Neurological Disorders
- Global Maternal and Child Health
- Neonatal and Maternal Infections
- Ectopic Pregnancy Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Pediatric Urology and Nephrology Studies
- Cardiovascular Issues in Pregnancy
- Pregnancy and Medication Impact
- Neonatal and fetal brain pathology
- Prostate Cancer Diagnosis and Treatment
Yale University
2007-2019
University of South Florida
2015-2016
The Ohio State University
2012-2014
Nationwide Children's Hospital
2014
SUNY Upstate Medical University
2014
The University of Texas Health Science Center at Houston
2014
Aston University
2014
Lehigh Valley Hospital-Pocono
2013
Lehigh Valley Health Network
2013
Society for Maternal-Fetal Medicine
1999-2013
To examine physician-documented indications for cesarean delivery in order to investigate the specific factors contributing increasing rate.
Minimal data exist concerning the relationship between hypertensive pregnancy disorders and various subsequent cardiovascular events effect of type 2 diabetes mellitus on these. In a registry-based cohort study, we identified women delivering in Denmark from 1978 to 2007 with first singleton (n=782 287) consecutive deliveries (n=536 419). The exposures were gestational hypertension mild severe preeclampsia. We adjusted for preterm delivery, small age, placental abruption, stillbirth and,...
Preeclampsia is a pregnancy-specific disorder of unknown etiology and leading contributor to maternal perinatal morbidity mortality worldwide. Because there no cure other than delivery, preeclampsia the cause iatrogenic preterm birth. We show that shares pathophysiologic features with recognized protein misfolding disorders. These include urine congophilia (affinity for amyloidophilic dye Congo red), affinity conformational state-dependent antibodies, dysregulation prototype proteolytic...
Many believe that preeclampsia is not associated with future morbidity or mortality. We sought to investigate the long-term risk of mortality in women preeclampsia, focusing on those known be subsequently normotensive.We ascertained deaths during 24-36 years' follow-up a cohort 37,061 who delivered Jerusalem 1964-1976, including 1,070 preeclampsia. used Cox proportional hazard models estimate while controlling for woman's age and education, history diabetes, heart disease low birth weight...
The International Association of the Diabetes and Pregnancy Study Groups (IADPSG) recently recommended new criteria for diagnosing gestational diabetes mellitus (GDM). This study was undertaken to determine whether adopting IADPSG would be cost-effective, compared with current standard care.
To determine whether routine measurement of second-trimester transvaginal cervical length by ultrasound in low-risk singleton pregnancies is a cost-effective strategy.We developed decision analysis model to compare the cost-effectiveness two strategies for identifying at risk preterm birth: (1) no screening and (2) single 18-24 weeks' gestation. In our model, women identified as being increased (cervical < 1.5 cm) birth would be offered daily vaginal progesterone supplementation. We assumed...
Background Proteomic analysis of amniotic fluid shows the presence biomarkers characteristic intrauterine inflammation. We sought to validate prospectively clinical utility one such proteomic profile, Mass Restricted (MR) score. Methods and Findings enrolled 169 consecutive women with singleton pregnancies admitted preterm labor or premature rupture membranes. All had a clinically indicated amniocentesis rule out intra-amniotic infection. A fingerprint (MR score) was generated from fresh...
Pettker, C.M.; Thung, S.F.; Norwitz, E.R.; Buhimschi, C.S.; Raab, C.A.; Copel, J.A.; Kuczynski, E.; Lockwood, C.J.; Funai, E.F. Author Information
In Brief OBJECTIVE: To compare neonatal outcomes by method of delivery in preterm (34 weeks gestation or prior), small-for-gestational-age (SGA) newborns a large diverse cohort. METHODS: Birth data for 1995–2003 from New York City were linked to hospital discharge data. Data limited singleton, liveborn, vertex neonates delivered between 25 and 34 gestation. Births complicated known congenital anomalies birth weight less than 500 g excluded. Small gestational age was used as surrogate...
Summary We investigated the association between inherited and acquired maternal thrombophilias adverse pregnancy events. A cohort of 491 patients with a history outcomes was evaluated for activated protein C resistance, factor V Leiden prothrombin G20210A mutations, hyperhomocysteinemia, deficiencies antithrombin, S both anticardiolipin antibodies lupus anticoagulants. The study had an 80% power to detect 15% difference in prevalence thrombophilia 1st trimester loss. In our high-risk...
Pre-eclampsia has been described as a 'disease of first pregnancies' and many believe that its occurrence in later pregnancy signals fundamentally different entity. We sought to compare risk factors subsequent pregnancies. studied 1319 cases pre-eclampsia recorded historical cohort 82,436 deliveries Jerusalem 1964-76. Logistic regression was used control for covariates. The adjusted odds ratio (OR) births 2.58 (95% confidence interval[CI] 2.23, 2.97), compared with all birth order groups,...
Extravillous trophoblasts (EVTs) invade human decidua via sequential integrin-mediated binding and proteolysis of basement membrane proteins in the extracellular matrix (ECM). In preeclampsia, shallow EVT invasion impairs spiral artery arteriole remodeling to reduce uteroplacental blood flow. Excess decidual cell-expressed metalloproteinases (MMPs) 2 9, response preeclampsia-related interleukin 1 beta (IL1B) tumor necrosis factor alpha (TNF), may inappropriately degrade these impede...
To compare neonatal neurologic complication rates of cesarean deliveries, forceps-assisted vaginal and vacuum-assisted deliveries.Data on singleton live births at 34 weeks or greater gestation born to nulliparous women from 1995 2003 in New York City were linked hospital discharge data. Any diagnosis subdural hemorrhage, intraventricular seizures, scalp laceration cephalohematoma, fracture, facial nerve palsy, brachial plexus injury, 5-minute Apgar score less than 7 was considered...
Decidual hemorrhage (abruption) is strongly associated with preterm premature rupture of fetal membranes (PPROM). Moreover, thrombin enhances decidual matrix metalloproteinase (MMP) expression, and MMP has been linked to PPROM. The current study sought determine whether increased activation, as assessed by circulating maternal plasma thrombin-antithrombin (TAT) complexes, predicted subsequent PPROM.We conducted a nested, case-control TAT levels, measured sensitive immunoassay, among 27 women...