A5092012970- Adenosine and Purinergic Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
Universidade Federal de Ciências da Saúde de Porto Alegre
2023-2024
The tumor microenvironment (TME) of glioblastoma (GB) is characterized by an increased infiltration immunosuppressive cells that attenuate the antitumor immune response. participation neutrophils in progression still controversial and a dual role TME has been proposed. In this study, we show are reprogrammed to ultimately promote GB progression.Using vitro vivo assays, demonstrate existence bidirectional neutrophil communication, directly promoting TME.Neutrophils have shown play important...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a global cancer burden with 5‐year overall survival rate of around 50%, stagnant for decades. A tumour‐induced immunosuppressive microenvironment contributes to HNSCC progression, the adenosine (ADO) pathway an upregulated expression inhibitory immune checkpoint regulators playing key role in this context. The correlation between high neutrophil‐to‐lymphocyte ratio (NLR) advanced tumour staging suggests involvement neutrophils (NØ)...