A5083663345- Hedgehog Signaling Pathway Studies
- PI3K/AKT/mTOR signaling in cancer
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Developmental Biology and Gene Regulation
- Genetic Syndromes and Imprinting
- Cancer Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Congenital Anomalies and Fetal Surgery
- Pediatric Hepatobiliary Diseases and Treatments
- MicroRNA in disease regulation
University of Turku
2022-2023
Åbo Akademi University
2022-2023
Universidad Nacional Autónoma de México
2011-2018
Tecnológico Nacional de México
2018
Instituto Nacional de Cancerología
2014
Alagille syndrome is a genetic disorder characterized by cholestasis, ocular abnormalities, characteristic facial features, heart defects, and vertebral malformations. Most cases are associated with mutations in JAGGED1 (JAG1), which encodes Notch ligand, although it not clear how these contribute to disease development. We aimed develop mouse model of elucidate mechanisms.Mice missense mutation (H268Q) Jag1 (Jag1+/Ndr mice) were outbred C3H/C57bl6 background generate for (Jag1Ndr/Ndr mice)....
The participation of NOTCH signaling in invasive cervical cancer (ICC) remains controversial since both tumor suppressive and oncogenic properties have been described. Additionally, the role NUMB, a negative regulator NOTCH, unclear ICC. We aimed to investigate NOTCH1 NUMB expression their localization intraepithelial neoplasia (CIN) ICC samples. A total 144 biopsies were obtained from Instituto Nacional de Cancerología, México 2004 2017, subjected immunohistochemistry for NUMB. found that...