A5074883658- Helicobacter pylori-related gastroenterology studies
- Alzheimer's disease research and treatments
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Reproductive tract infections research
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- Microbial Metabolites in Food Biotechnology
- Animal Genetics and Reproduction
- Cancer Genomics and Diagnostics
- Computational Drug Discovery Methods
- Neurological and metabolic disorders
- RNA modifications and cancer
- Airway Management and Intubation Techniques
- Sperm and Testicular Function
- Health and Lifestyle Studies
- Veterinary medicine and infectious diseases
- Gastric Cancer Management and Outcomes
- Renal and related cancers
- Parkinson's Disease Mechanisms and Treatments
- Gastrointestinal disorders and treatments
- Renal cell carcinoma treatment
- Health, Education, and Physical Culture
- Cholinesterase and Neurodegenerative Diseases
- 14-3-3 protein interactions
Universidad de Antioquia
1997-2025
ORCID
2019-2020
St Mary's Hospital
2013
University of Birmingham
1999-2002
Glenfield Hospital
2001
Washington University in St. Louis
1995-1997
Molecular Discovery (United Kingdom)
1996
University of South Florida
1996
Collaborative Group (United States)
1995
The presenilin 1 gene has recently been identified as the locus on chromosome 14 which is responsible for a large proportion of early onset, autosomal dominantly inherited Alzheimer's disease (AD). We have elucidated intron/exon structure and designed intronic primers to enable direct sequencing entire coding region (10 exons) in number families. This strategy enabled us find further two novel mutations gene. discuss distribution proportions dominant AD with mean age onset below 60 years...
A single base substitution of a glutamic acid to an alanine codon 280 was found in the presenilin-1 (PS-1) gene on chromosome 14 affected individuals each seven Colombian early-onset Alzheimer's disease (AD) kindreds. The mutation segregated with kindreds tested. In largest kindred (C2), maximum two-point lod score between and AD Z = 8.14 at θ 0. presence common geographic origin, all families from state Antioquia, suggest founder effect this population. This finding is supported by...
<i>Aims</i>—Chromosome 3p deletions and loss of heterozygosity (LOH) for markers are features clear cell renal carcinoma but rare in non-clear carcinoma. The VHL tumour suppressor gene, which maps to 3p25, is a major gatekeeper gene inactivated most sporadic cases this disease. However, it has been suggested that inactivation other genes might be crucial tumorigenesis, with (VHL negative) without positive) the gene. This study set out investigate role non-VHL negative positive...
ABSTRACT Estimates suggest that over 50% of the global population suffer from Helicobacter pylori infections. Nowadays, first-line quadruple therapy is recommended to eradicate bacteria due increasing failures standard triple therapy. Thus, antibiotics such as furazolidone have emerged a new treatment their success rate (>90%) in rescue therapies. Nevertheless, not routinely used for H. Colombia. Still, some Asian countries commonly prescribe it. This study aimed determine susceptibility...
<i>Aims</i>—Chromosome 3p allele loss is a frequent event in many common sporadic cancers including lung, breast, kidney, ovarian, and head neck cancer. To analyse the extent frequency of allelic losses T1N0 T1N1 invasive breast cancer, 19 microsatellite markers spread along were analysed 40 such carcinomas with known clinicopathological parameters. <i>Methods</i>—Loss heterozygosity analysis was carried out using that non-randomly distributed chosen to represent regions show hemizygous...
Abstract Background Culturing primary epithelial cells has a major advantage over tumor-derived or immortalized cell lines as long their functional phenotype and genetic makeup are mainly maintained. The swine model shown to be helpful reliable when used surrogate for human diseases. Several porcine have been established based on variety of tissues, which extensively contribute the current understanding several pathologies, especially cancer. However, protocols isolation culture gastric that...
Helicobacter pylori (H. pylori) es un bacilo gramnegativo microaerófilo, capaz de colonizar la mucosa gástrica. Este microorganismo infecta a más mitad población mundial, por lo que se ha convertido en infección bacteriana común. La prevalencia y las enfermedades asociadas ella alta, sobre todo países vías desarrollo. El tratamiento recomendado para erradicación triple terapia; sin embargo, su eficacia disminuido el desconocimiento del patrón susceptibilidad bacteriano parte personal médico...
SUMMARY Background: Microorganisms can find the optimal conditions for survival in semen, causing damage to spermatozoa and triggering processes of infertility or reproductive tract infections. Therefore, understanding role microorganisms present semen help improve diagnosis cases where only apparent cause is infectious processes. Objective: To describe correlate parameters bacterial growth ejaculate. Methods: Identification isolated 43 clinical spermocultures 28 research spermocultures. We...
A single base substitution of a glutamic acid to an alanine codon 280 was found in the presenilin-1 (PS-1) gene on chromosome 14 affected individuals each seven Colombian early-onset Alzheimer's disease (AD) kindreds. The mutation segregated with kindreds tested. In largest kindred (C2), maximum two-point lod score between and AD Z = 8.14 at θ 0. presence common geographic origin, all families from state Antioquia, suggest founder effect this population. This finding is supported by...
Las enfermedades crónicas no transmisibles, incluido el cáncer, están sobrepasando a las infecciosas como la principal amenaza de salud en países Colombia. La economía colombiana está creciendo rápidamente, conduciendo al aumento calidad vida. Este crecimiento se acompaña cambios como: del tabaquismo, estilos vida sedentarios, consumo alcohol, hábitos alimentarios saludables, mayor exposición contaminantes ambientales cancerígenos y envejecimiento población, lo que explica los casos cáncer...
Objetivo: determinar la frecuencia de Helicobacter pylori y presencia factores sociodemográficos, hábitos vida antecedentes personales familiares enfermedades gastroduodenales en pacientes que requirieron fueron llevados a endoscopia digestiva (sintomáticos o por tamización) siete unidades tres subregiones Antioquia. Materiales métodos: estudio transversal realizado entre 2016 2018 incluyó 272 participantes. Los vida, se relacionaron con infección H. pylori. Se realizó estadística...
Objective To determine the prevalence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) in homeless population Medellín, Colombia, using molecular diagnostic methods. It also intended to develop a demographic profile, exploring associated factors dynamics social sexual interactions this community. Design Cross-sectional study. Setting Two care centres Colombia. Participants Homeless individuals that assisted main Colombia from 2017 2019. Primary secondary outcome measures The CT...