A5017123335- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Antioxidant Activity and Oxidative Stress
- Retinal and Macular Surgery
- Connexins and lens biology
- Retinoids in leukemia and cellular processes
- Wound Healing and Treatments
- Ocular Diseases and Behçet’s Syndrome
- RNA Interference and Gene Delivery
- Eicosanoids and Hypertension Pharmacology
- Acute Ischemic Stroke Management
- Gold and Silver Nanoparticles Synthesis and Applications
- Ocular Surface and Contact Lens
- Biochemical Acid Research Studies
- Ocular Infections and Treatments
- Cholesterol and Lipid Metabolism
- Vitamin C and Antioxidants Research
- interferon and immune responses
- Complement system in diseases
- Signaling Pathways in Disease
Clinica Universidad de Navarra
2013-2025
Instituto de Salud Carlos III
2019-2024
Ministerio de Ciencia, Innovación y Universidades
2020-2024
Navarre Institute of Health Research
2015-2024
Universidad de Navarra
2013-2024
Centro de Investigación Biomédica en Red
2020-2021
University College London
2015-2017
Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine
2011
University Dermatology
2005
Diabetic retinopathy is a vision-threatening microvascular complication of diabetes and one the leading causes blindness. Oxidative stress inflammation play major role in its pathogenesis, new therapies counteracting these contributors could be great interest. In current study, we investigated vitamin D against oxidative human retinal pigment epithelium (RPE) endothelial cell lines. We demonstrate that effectively counteracts induced by hydrogen peroxide (H2O2). addition, increased levels...
The purpose of this study is evaluate the efficacy and safety medicinal products containing original Age-Related Eye Disease group (AREDS) formulation at doses approved in Europe (EU, control group; n = 59) with a product that adds DHA, lutein, zeaxanthin, resveratrol hydroxytyrosol to formula (intervention 50). This was multicenter, randomized, observer-blinded trial conducted patients aged 50 years or older diagnosed unilateral exudative Age related Macular Degeneration AMD. At month 12,...
Retinal pigment epithelium (RPE) is a key regulator of retinal function and directly related to the transport, delivery, metabolism long-chain n-3 polyunsaturated fatty acids (n3-PUFA), in retina. Due their functions location, RPE cells are constantly exposed oxidative stress. Eicosapentaenoic acid (EPA) docosahexaenoic (DHA) have shown antioxidant effects by different mechanisms. For this reason, we designed an vitro study compare 10 formulations DHA EPA supplements from origins combined...
Abstract Purpose To assess the effect of fluid status at baseline (BL) and end loading phase (LP) three different ranibizumab regimens: treat‐and‐extend (T&E), fixed bimonthly (FBM) injections pro re nata (PRN), in patients with neovascular age‐related macular degeneration (nAMD). Design Post hoc analysis In‐Eye study (phase IV clinical trial). Methods Patients were randomized 1:1:1 to arms treated accordingly. The presence type fluid, intraretinal (IRF) or subretinal (SRF) anatomical...
Age-related macular degeneration (AMD) has a strong genetic component with major locus at 1q31, including the complement factor H (CFH) gene. Detailed analyses of this have demonstrated existence one SNP haplotype block, carrying CFH 402His allele, which confers increased risk for AMD, and two protective haplotypes, them deletion CFHR1 CFHR3 genes (ΔCFHR3-CFHR1). The purpose these studies was to evaluate contribution newly described alleles association 1q31 AMD.Two hundred fifty-nine...
Identification of the genetic risk factors that contribute to geographic atrophy (GA) could lead advancements in interventional trials and/or therapeutic approaches for combating vision loss.To investigate whether single-nucleotide polymorphisms (SNPs) are associated with presence and progression established GA age-related macular degeneration (AMD).Prospective, controlled, multicenter study 154 patients GA/AMD 141 age-matched control participants at 8 Spanish hospitals.Samples DNA were...
Abstract Purpose To assess the effect of clinical factors on development and progression atrophy fibrosis in patients with neovascular age‐related macular degeneration (nAMD) receiving long‐term treatment real world. Methods An ambispective 36‐month multicentre study, involving 359 nAMD from 17 Spanish hospitals treated according to Vitreoretinal Society guidelines, was designed. The influence demographic factors, including presence location retinal fluid, best‐corrected visual acuity (BCVA)...
Purpose. To estimate the prevalence and causes of bilateral blindness visual impairment in an urban institutionalized population aged 65 years older. Methods. A total 392 nursing home residents completed a standardized eye examination, including measurement acuity (VA), intraocular pressure, lens opacity grading, indirect ophthalmoscopy, photography macular area. The major vision loss identified for all participants were impairment. Results. average subject age was 82 (65–97); women...
The purpose of this study was to assess the effects transforming growth factor beta (TGF-β) inhibitor peptides (P17 & P144) on early laser-induced choroidal neovascularization (LI-CNV) lesions in rats, two weeks after laser CNV induction. Seventy-one Long Evans rats underwent diode application an established LI-CNV model. Baseline fluorescein angiography (FA) performed 14 days following procedure, and treatments were administered 16 post-laser via different administration routes. Intravenous...
Oxidative stress is involved in the pathogenesis of several diseases such as atherosclerosis and age-related macular degeneration (AMD). ApoE-deficient mice (apoE −/− ) are a well-established model genetic hypercholesterolemia develop retinal alterations similar to those found humans with AMD. Thus supplementation lutein or multivitamin plus glutathione complex (MV) could prevent onset these alterations. ApoE (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract Purpose We sought to determine if specific genetic single nucleotide polymorphisms (SNPs) influence vascular endothelial growth factor inhibition response ranibizumab in neovascular age‐related macular degeneration (AMD). Methods A total of 403 Caucasian patients diagnosed with exudative AMD were included. After a three‐injection loading phase, pro re nata regimen was followed. Nine SNP s from six different genes ( CFH , CFB ARMS 2, SERPINF 1, VEGFR VEGF ) genotyped. Non‐genetic...
Age-related macular degeneration (AMD) is a multifactorial disease of the retina featured by dysfunction retinal pigmented epithelial (RPE) and loss photoreceptor cells under oxidative stress inflammatory conditions. Vitamin D antioxidants have beneficial effects against degenerative diseases, such as AMD. We investigated impact associating vitamin (ND) with nutritional antioxidant complex (Nutrof Total®; N) on inflammation-like induced conditions H2O2 LPS, respectively, in human (ARPE-19)...
<title>Abstract</title> Choroidal neovascularization (CNV) and inflammation processes play an important role in retinal disease development C-reactive protein (CRP) has been shown to contribute diseases like Age-related macular degeneration (AMD). Our aim was evaluate whether monomeric pentameric CRP (pCRP, mCRP) isoforms CNV vivo characterize the mechanism of dissociation in-vivo vitro. Both were intravitreally (IVT) or intravenously (IV) injected mice, laser-induced, retinography...
<title>Abstract</title> Choroidal neovascularization (CNV) and inflammation processes play an important role in retinal disease development C-reactive protein (CRP) has been shown to contribute diseases like Age-related macular degeneration (AMD). Our aim was evaluate whether monomeric pentameric CRP (pCRP, mCRP) isoforms CNV vivo characterize the mechanism of dissociation in-vivo vitro. Both were intravitreally (IVT) or intravenously (IV) injected mice, laser-induced, retinography...
Oxidative stress is thought to be involved in the pathogenesis of age-related diseases, such as atherosclerosis and retinal degeneration. The current study was conducted examine vitreoretinal oxidative status a model porcine hypercholesterolemia identify morphologic alterations analyze effect dietary supplementation with vitamins C E.Adult miniature pigs were fed standard chow, cholesterol-rich or diet supplemented E. Total cholesterol, triglycerides, high-density lipoproteins, lipid...
Photochemical damage occurs after an exposure to high energy radiation within the visible spectrum of light, causing morphological changes in retina and formation superoxide anion. In this study we created a model phototoxicity rabbits. Animals were exposed light source for 120 minutes sacrificed immediately or one week exposure. Outer nuclear layer neurosensory thickness measurements photoreceptor counting performed. Caspase-1 caspase-3 assessed by immunohistochemistry. Dihydroethidium was...
We assessed the sustained delivery effect of poly (lactic-co-glycolic) acid (PLGA)/vitamin E (VitE) microspheres (MSs) loaded with glial cell-derived neurotrophic factor (GDNF) alone (GDNF-MSs) or combined brain-derived (BDNF; GDNF/BDNF-MSs) on migration human adult retinal pigment epithelial cell-line-19 (ARPE-19) cells, primate choroidal endothelial (RF/6A) and survival isolated mouse ganglion cells (RGCs). The morphology MSs, particle size, encapsulation efficiencies active substances...
Purpose.: To assess the effect of transforming growth factor (TGF)-β inhibitor peptides (P17 and P144) on development laser-induced choroidal neovascularization (LI-CNV) in a rat model. Methods.: Sixty-one Long-Evans rats underwent diode LI-CNV Forty-eight hours later, treatment was administered. The intravenous control group (IV-control) P17 (IV-17) received five doses (0.2 mg every 72 hours) vehicle P17, respectively. Four groups intravitreal injections low-dose (LD-17; 1 mg/mL) high-dose...
Background: The objective of this study was to evaluate the association presence conjunctival ultraviolet autofluorescence (CUVAF) with level and progression myopia impact reduced sunlight exposure during COVID-19 pandemic confinement (PC). Methods: A retrospective observational carried out using three cohorts, children (9–17 years old), young adults (18–25 (>40 old) (≤0.75D) at least annual eye examinations (before after PC). All participants underwent an automatic refraction CUVAF area...