A5080313958- Thyroid and Parathyroid Surgery
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Parathyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Head and Neck Anomalies
- Voice and Speech Disorders
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Sympathectomy and Hyperhidrosis Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroblastoma Research and Treatments
- Genetic Syndromes and Imprinting
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- BRCA gene mutations in cancer
- Cancer Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Spinal Fractures and Fixation Techniques
- Tracheal and airway disorders
- Esophageal and GI Pathology
Onze Lieve Vrouwziekenhuis Hospital
2014-2025
Janssen (Belgium)
2025
American Society of Safety Professionals
2025
Janssen (United States)
2024
Hammersmith Hospital
2020-2023
Pitié-Salpêtrière Hospital
2022-2023
Sorbonne Université
2022-2023
Imperial College Healthcare NHS Trust
2021-2023
Assistance Publique – Hôpitaux de Paris
2022-2023
Lund University
2021-2022
Abstract The membrane (M) protein of betacoronaviruses is well conserved and has a key role in viral assembly 1,2 . Here we describe the identification JNJ-9676, small-molecule inhibitor targeting coronavirus M protein. JNJ-9676 demonstrates vitro nanomolar antiviral activity against SARS-CoV-2, SARS-CoV sarbecovirus strains from bat pangolin zoonotic origin. Using cryogenic electron microscopy (cryo-EM), determined binding pocket formed by transmembrane domains dimer. Compound stabilized...
Chemokines and chemokine receptors are key modulators in inflammatory diseases malignancies. Here, we describe the identification pharmacologic characterization of nanobodies selectively blocking CXCR2, most promiscuous all receptors. Two classes selective monovalent were identified, detailed epitope mapping showed that these bind to distinct, nonoverlapping epitopes on CXCR2 receptor. The N-terminal-binding or class 1 possessed potencies single-digit nanomolar range but lacked complete...
Postoperative outcomes of patients with normotensive pheochromocytomas are poorly documented. We aimed to evaluate the impact preoperative hypertension on post-operative following adrenalectomy for pheochromocytoma. An international retrospective study undergoing pheochromocytoma in 46 centers between 2012-2022 was performed. Hypertensive and were defined respectively by presence or absence history before at time diagnosis. To differences postoperative hypertensive patients, propensity score...
Postoperative hypocalcaemia, recurrent laryngeal nerve palsy and postoperative bleeding are the most frequent complications after thyroid surgery, therefore often used as quality indicators of surgery. We aimed to assess morbidity in a high-volume endocrine surgery unit, detect which factors associated with higher risks. Prospective surgical cohort tertiary referral centre for xxx. The first 1500 patients operated hemi or total thyroidectomy during 2010–2019 were included. assessed relation...
Adrenal cortical carcinoma (ACC) is a rare and aggressive endocrine malignancy. Clinical symptoms are mainly related to excess hormone secretion. Hypercortisolism virilisation among the most common presentations. We report case series of five patients with ACC, three which presented as adrenal incidentalomas. Additionally, literature review on current diagnosis management ACC was performed. ACCs often incidentally detected because liberal use medical imaging. Management remains challenging,...
To determine the incidence and risk factors for postoperative complications prolonged hospital stay after adrenalectomy phaeochromocytoma.Demographics, perioperative outcomes were evaluated consecutive patients who underwent phaeochromocytoma from 2012 to 2020 in nine high-volume UK centres. Odds ratios calculated using multivariable models. The primary outcome was according Clavien---Dindo classification secondary duration of stay.Data available 406 (female n = 221, 54.4 per cent). Two (0.5...
This European Society of Endocrine Surgeons (ESES) guideline provides evidence-based recommendations based on the surgical management for locally advanced pancreatic neuroendocrine neoplasms, indications neoadjuvant therapy, primary tumor resections in setting metastatic disease and Grade 3 tumours carcinoma.
Abstract Background Small bowel neuroendocrine tumours often present with locally advanced or metastatic disease. The aim of this paper is to provide evidence-based recommendations regarding (controversial) topics in the surgical management small tumours. Methods A working group experts was formed by European Society Endocrine Surgeons. addressed 11 clinically relevant questions surgery for disease, including benefit primary tumour resection, role cytoreduction, extent lymph node clearance,...
conference papers, and studies regarding laboratory, genetics mutations were excluded.Management of advanced parathyroid cancers
Phaeochromocytomas/paraganglioma (PPGL) surgery was historically associated with significant risks of perioperative complications. The decreased mortality (<3.0%) had been attributed in part to optimal preoperative alpha-blockade. value alpha-blockade decreasing morbidity is being challenged. aim our study present an institutional experience alpha-blocking PPGL and its effect on cardiovascular stability postoperative morbidity.A retrospective using data from database conducted. All patients...