A5012281048- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Pituitary Gland Disorders and Treatments
- Nutrition and Health in Aging
- Lung Cancer Research Studies
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Clinical Nutrition and Gastroenterology
- Hormonal Regulation and Hypertension
- RNA Research and Splicing
- Body Composition Measurement Techniques
- Growth Hormone and Insulin-like Growth Factors
- Inflammasome and immune disorders
- Vitamin D Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Cardiovascular Disease and Adiposity
- RNA modifications and cancer
- Dysphagia Assessment and Management
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Mosquito-borne diseases and control
- Transplantation: Methods and Outcomes
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
Instituto Maimónides de Investigación Biomédica de Córdoba
2016-2025
Hospital Universitario Reina Sofía
2016-2025
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2019-2023
University of Córdoba
2019-2022
Erasmus MC
2013-2019
Erasmus University Rotterdam
2019
Universidad de Alcalá
2017
Sociedad Española de Endocrinología y Nutrición
2014
Universidad Centroccidental Lisandro Alvarado
2010
Background: A nationwide, prospective, multicenter, cohort study (the Disease-Related caloric-protein malnutrition EChOgraphy (DRECO) study) was designed to assess the usefulness of ultrasound rectus femoris for detecting sarcopenia in hospitalized patients at risk and define cut-off values measures. Methods: Patients according Malnutrition Universal Screening Tool (MUST) underwent handgrip dynamometry, bioelectrical impedance analysis (BIA), a Timed Up Go (TUG) test, studies. European...
Introduction Bioelectrical impedance analysis (BIA) serves as a method to estimate body composition. Parameters such phase angle (PA), standardized (SPA), mass cell (BCM), BCM index (BCMI), and fat-free (FFM) might significantly impact the prognosis of head neck cancer (HNC) patients. The present study aimed investigate whether bioelectrical parameters can be used predict survival in HNC population establish optimal cutoff points for predictive accuracy. Methods A multicenter observational...
(1) Background: Malnutrition frequently affects patients with cancer, and it negatively impacts treatment tolerance, clinical outcomes survival. Thus, appropriate nutritional screening early nutrition support are extremely recommended. Currently, a significant number of oral supplements (OS) commercially available; despite this, there is lack evidence for recommending specific OS, including leucine-enriched in cancer. (2) Aim: To compare the evolution cancer (undergoing systemic treatment)...
Biguanides and statins exert beneficial effects on various cancer types. Their precise underlying molecular mechanisms are poorly understood. We analyzed the relationship between metabolic syndrome histological, epidemiological, prognosis variables in two cohorts of patients with neuroendocrine tumors (NETs): those lung carcinoids (LCs; n = 81) gastroenteropancreatic NET (GEP-NET; 100). Biguanide statin antitumor were investigated by evaluating proliferation, migration, secretion, gene...
lipid profile suffers adaptive changes during pregnancy due to estrogen stimulation and insulin resistance. Several relations have been suggested between maternal profile, glucose tolerance, endothelial cell dysfunction long-term cardiovascular risk; the effects of metabolism in fetal growth are also inconclusive. Since a regular evaluation follow-up has not established yet, we aimed evaluate incidence dyslipidemia patients with gestational diabetes (GDM) analyze some putative pregnancy,...
Abstract Context Pituitary neuroendocrine tumors (PitNETs) are a commonly underestimated pathology in terms of incidence and associated morbimortality. Currently, an appreciable subset patients resistant or poorly responsive to the main current medical treatments [i.e., synthetic somatostatin analogs (SSAs) dopamine agonists]. Thus, development optimization novel available therapies is necessary. Biguanides (metformin, buformin, phenformin) antidiabetic drugs that exert antitumoral actions...
Background: Malnutrition and sarcopenia frequently affect patients with heart failure (HF), in which clinical outcomes survival is decreased. Thus, appropriate nutritional screening early nutrition support are highly recommended. Currently, not a standard of care HF, the use commercially available oral supplements (OSs) could provide an additional benefit to medical treatment these patients. Aim: To compare effect Mediterranean diet combination hypercaloric, hyperproteic OS HF. Patients...
Postoperative outcomes of patients with normotensive pheochromocytomas are poorly documented. We aimed to evaluate the impact preoperative hypertension on post-operative following adrenalectomy for pheochromocytoma. An international retrospective study undergoing pheochromocytoma in 46 centers between 2012-2022 was performed. Hypertensive and were defined respectively by presence or absence history before at time diagnosis. To differences postoperative hypertensive patients, propensity score...
weight loss is commonly observed in head-neck cancer patients, affecting 75-80% of them during their treatment period; severe 30-50% cases. According to ESPEN publications, nutritional assessment patients should be frequently performed and nutrition support therapy must started when any deficiency observed.to evaluate the effect early (ENS) markers response with receiving radiotherapy (RT).one hundred two more than points malnutrition screening tool (MUST) before RT were included. ENS was...
Obesity is a major health problem associated with severe comorbidities, including type 2 diabetes and cancer, wherein microRNAs (miRNAs) might be useful as diagnostic/prognostic tools or therapeutic targets.To explore the differential expression pattern of miRNAs in obesity their putative role obesity-related comorbidities such insulin resistance.An Affymetrix-miRNA array was performed plasma samples from normoweight (n = 4/body mass index < 25) obese subjects > 30). The main changes were...
Abstract Background Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of tumors ranging from indolent lesions with good prognosis to highly aggressive cancers. Carcinoids are the rarest LungNENs, display low intermediate malignancy and may be surgically managed, but show resistance radiotherapy/chemotherapy in case metastasis. Molecular profiling is providing new information understand lung carcinoids, its clinical value still limited. Altered alternative splicing...
Cortisol has immunomodulatory effects that increase the risk and evolution of several diseases. Cancer is characterized by a proinflammatory state in which cells exert impaired function proliferation. The relation between cortisol secretion increased malignant neoplasm, or their behavior, not been fully elucidated. To determine prevalence clinical outcome neoplasms patients with adrenal incidentalomas (AIs). Multicenter retrospective study included 935 AIs. was defined post-dexamethasone...
Carcinoid heart disease (CHD) is a frequent and life-threatening complication in patients with carcinoid tumors. Its clinical management challenging some cases since serotonin-induced valve fibrosis leads to failure. Telotristat an inhibitor of tryptophan-hydroxylase (TPH), key enzyme serotonin production. use syndrome uncontrollable diarrhea under somatostatin analogs approved, but its specific role CHD still not clear. IN this context, we aimed explore the effect telotristat using mouse...
Increased inflammation is associated with the pathogenesis of heart failure (HF). circulating levels cytokines have been previously reported and generally worse clinical outcomes. In this context, modulation inflammation-related parameters seems to be a reasonable therapeutic option for improving course disease. Based on this, we aimed compare changes in when Mediterranean diet alone or combination hypercaloric, hyperproteic oral nutritional supplements (ONS), enriched omega−3 (n−3)...