A5100743986- Microbial Natural Products and Biosynthesis
- Prostate Cancer Treatment and Research
- Computational Drug Discovery Methods
- Streptococcal Infections and Treatments
- Pediatric Urology and Nephrology Studies
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Cancer, Stress, Anesthesia, and Immune Response
- Synthesis and biological activity
- Clostridium difficile and Clostridium perfringens research
- Voice and Speech Disorders
- Myasthenia Gravis and Thymoma
- T-cell and Retrovirus Studies
- Microbial Metabolism and Applications
- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Research and Treatments
- Artificial Intelligence in Healthcare
- Tracheal and airway disorders
- Cancer therapeutics and mechanisms
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Cancer-related gene regulation
- Gastrointestinal Tumor Research and Treatment
Shanxi Medical University
2024-2025
Wenzhou Medical University
2022-2025
First Affiliated Hospital of Wenzhou Medical University
2022-2025
Chinese PLA General Hospital
2014-2024
South China Sea Institute Of Oceanology
2021-2024
First Affiliated Hospital Zhejiang University
2024
State Key Laboratory of Cardiovascular Disease
2024
Sichuan University
2024
Shenzhen Institutes of Advanced Technology
2024
Institute of Oceanology
2021-2024
Abstract Background Numerous studies have revealed a tight connection between tumor development and the coagulation system. However, effects of on prognosis microenvironment (TME) clear cell renal carcinoma (ccRCC) remain poorly understood. Methods We employed consensus clustering method to characterize distinct molecular subtypes associated with patterns. Subsequently, we examined variations in overall survival (OS), genomic profiles, TME characteristics these subtypes. To develop...
Prostatic malakoplakia (PMP) is a rare inflammatory disease, and misdiagnosis on imaging major reason for unnecessary punctures; however, information even rarer. Five patients with PMP between May 2022 February 2023 were enrolled in this study to summarize the manifestations. All underwent ultrasound (US)-guided prostate biopsy confirmed by pathology, presence of cancer was also excluded pathology. The five patients, median age 71 years (range = 58–74 years), had total prostate-specific...
Abstract Current treatment options for prostate cancer focus on targeting androgen receptor (AR) signaling. Inhibiting effects of AR may activate neuroendocrine differentiation and lineage plasticity pathways, thereby promoting the development (NEPC). Understanding regulatory mechanisms has important clinical implications this most aggressive type cancer. Here, we demonstrated tumor-suppressive role found that activated could directly bind to sequence muscarinic acetylcholine 4 ( CHRM4 )...
In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity ETS-1. The protein interaction was identified between ETS-1 and lovo cells. accumulating data showed that promoted the recruitment to endogenous promoter its target genes increase accumulation nuclear. Our work also indicated enhances via down-regulating p53-mediated inhibition on Further, plays regulation colorectal carcinoma cells proliferation. These findings supported might be molecule...
Tocilizumab, a monoclonal antibody against interleukin-6, has been used to treat cytokine release syndrome (CRS) in subset of patients with severe COVID-19 disease. Acute ulcerative bowel disease only rarely documented treated for rheumatological conditions. The gastrointestinal side effects seen when the context are unknown. We present case CRS which acute terminal ileum and perforated caecal ulceration evolved after tocilizumab exposure. raise awareness possible causal relationship between...
As a new diagnosis and treatment decision-making model, shared decision making (SDM) can effectively solve the problem of patient compliance in thoracic tumors, balance status both doctors patients, gradually get attention application clinical practice surgery. The SDM tumors is conducive to improve doctors' level alleviating pressure responsibility, reduce patients' psychological also medical trust doctor-patient conflict. Due limited literacy autonomy time for short due imbalance ratio....
Chemical investigation of the EtOAc extract a deep-sea derived fungus
Abstract Neuroendocrine differentiation (NED) is associated with WNT signaling activation and can be significantly observed after failure of androgen-deprivation therapy (ADT) for prostatic adenocarcinomas. Cytokine stimulated in NED prostate cancer; however, how ADT-upregulated promotes cytokine contributes to cancer poorly understood. In this study, we identified ADT-mediated upregulation transcription factor 7 like 1 (TCF7L1), which increases the response enhances through interleukin...
The chemical investigation of the EtOAc extract from solid rice medium cultured with a sponge-associated fungus Penicillium sp. SCSIO41033 led to isolation two quinolones including new one, penicinolone (1), three xanthone derivatives (3-5), and four anthraquinones (6-9). Their structures were determined by comprehensive analysis 1H 13C NMR, COSY, HSQC, HMBC spectroscopic, HRESIMS mass spectrometric data. bioactive assays revealed that compounds 1 2 showed no antimicrobial activities against...
Diarrhea is one of the most commonly reported diseases in young farm animals. Escherichia coli (E. coli) F17 major pathogenic bacteria responsible for diarrhea. However, pathogenicity diarrhea lambs involving E. strains and how infection modifies lambs’ intestinal microbiota are largely unknown. To evaluate newborn with an F17, 50 were selected challenge experiments divided into four groups, namely, a high-dose group, low-dose positive control negative group. The caused increased mortality...
Three new tetramic acid derivatives ( 1 – 3 ) and a polyketide 4 along with eight known compounds 5 12 were isolated from cultures of the deep-sea-derived fungus Penicillium sp. SCSIO06868. Four structures elucidated by analysis one-dimensional/two-dimensional nuclear magnetic resonance (NMR) data high-resolution electrospray ionization mass spectrometry. Their absolute configurations established X-ray crystallography comparison experimental reported electronic circular dichroism (ECD)...
We present a case of 64-year-old gentleman for whom point care ultrasound (POCUS) expedited the diagnosis and subsequent early treatment colon adenocarcinoma. He was referred by his primary provider to our clinic abdominal bloating. had no other symptoms such as pain, change in bowel habits or rectal bleeding. constitutional weight loss. The patient's examination also unremarkable. However, POCUS identified 6 cm long hypoechoic circumscribed wall thickening around hyperechoic pattern lumen...
Abstract Objective To investigate the safety and feasibility of super-pulsed thulium fiber laser under transurethral flexible ureteroscopy in treatment parapelvic cysts combined with renal stones. Patients methods Twelve patients stones admitted from October 2022 to May 2023 were treated internal incision drainage simultaneously. CT scans performed at 1, 3, 6 months postoperative assess stones, respectively. Results The mean age was 61.5 ± 7.5 years. size 5.6 0.7 cm. 15.6 3.2 mm. density all...
Abstract Background : The complexity of systemic variables and comorbidities make it difficult to determine the best treatment for patients with hepatocellular carcinoma (HCC). It is impossible perform a multidimensional evaluation every patient, but guidelines based on analyses said complexities would be next option. Traditional statistics are inadequate developing predictive models many variables; however, data mining well-suited task. Patients Methods finding clinical profiles total 537...
Brunner's gland adenoma is extremely uncommon small bowel tumors with an incidence of <0.01% and account for less than 1% all gastrointestinal tumors. They are branched acinotubular glands found within the submucosal layer located between pyloric ring major duodenal papilla. produce alkaline secretion containing viscous mucin to protect duodenum from acidic gastric chyme. Although these lesions usually asymptomatic incidentally discovered on upper endoscopy, they may occasionally present...