A5009545682- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Human Health and Disease
- Digestive system and related health
- Diet, Metabolism, and Disease
- Medical and Biological Sciences
- Biomarkers in Disease Mechanisms
- Diabetes Management and Research
- Healthcare Systems and Public Health
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Pancreatic function and diabetes
- Pediatric Hepatobiliary Diseases and Treatments
- Diagnosis and treatment of tuberculosis
- IgG4-Related and Inflammatory Diseases
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Myopathies and Dermatomyositis
- Celiac Disease Research and Management
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Diabetes and associated disorders
- Food Industry and Aquatic Biology
Martin Luther University Halle-Wittenberg
2024
Abbott (Switzerland)
2021
Donetsk National Medical University
2010-2020
Ministry of Health
2020
Bogomolets National Medical University
2018
The overall objective of these guidelines is to provide evidence‐based recommendations for the diagnosis and management immunoglobulin G4 (IgG4)‐related digestive disease in adults children. IgG4‐related can be diagnosed only with a comprehensive work‐up that includes histology, organ morphology at imaging, serology, search other involvement, response glucocorticoid treatment. Indications treatment are symptomatic patients obstructive jaundice, abdominal pain, posterior pancreatic...
OBJECTIVES: Pancreatic-enzyme replacement therapy (PERT) is the standard of care to prevent maldigestion, malnutrition, and excessive weight loss in patients with exocrine pancreatic insufficiency (EPI) due chronic pancreatitis (CP) or surgery (PS). Our objective was assess efficacy safety a new formulation pancrelipase (pancreatin) delayed-release 12,000-lipase unit capsules (CREON) EPI CP PS. METHODS: This double-blind, randomized, multicountry, placebo-controlled, parallel-group trial...
Background and aims Autoimmune pancreatitis (AIP) is an immune-mediated disease of the pancreas with distinct pathophysiology manifestations. Our were to characterize type 1 AIP in a large pan-European cohort study effectiveness current treatment regimens. Methods We retrospectively analyzed adults diagnosed since 2005 or not-otherwise-specified 42 European university hospitals. Type was uniformly using specific diagnostic criteria. Patients 2 those who had undergone pancreatic surgery...
Abstract Pancreatic exocrine insufficiency (PEI) is defined as a reduction in pancreatic secretion below the level that allows normal digestion of nutrients. disease and surgery are main causes PEI. However, other conditions upper gastrointestinal can also affect digestive function pancreas. PEI cause symptoms nutritional malabsorption deficiencies, which quality life increase morbidity mortality. These guidelines were developed following United European Gastroenterology framework for...
The combined use of hepatoprotectors may aim to expand the spectrum hepatotropic action or unidirectionally increase a particular pharmacological effect due summation potentiation (synergism). An example effects ademetionine and silymarin is study that showed for first time combination silybinin inhibits inflammation oxidative stress through two separate signaling pathways. Both inhibit accumulation fat in liver, which was confirmed pilot clinical study. In patients with metabolic‑associated...
Pancreatic exocrine insufficiency (PEI) is defined as a reduction in pancreatic secretion below level that allows normal digestion of nutrients. disease and surgery are the main causes PEI, but other conditions upper gastrointestinal can affect digestive function pancreas. PEI cause symptoms nutrient malabsorption nutritional deficiencies, which quality life increase morbidity mortality. There no test allowing for diagnosis PEI. Diagnosis should therefore be based on global assessment...
Pancreatic enzyme-replacement therapy (PERT), provided as pancreatin to patients with pancreatic exocrine insufficiency (PEI), is considered an essential substitute for the pivotal physiological function pancreas fulfills in digestion. PEI involves a reduction synthesis and secretion of enzymes (lipase, protease, amylase), which leads inadequate enzymatic response meal consequently maldigestion malabsorption nutrients. The efficacy PERT strongly dependent on enzyme activity, dissolution,...
The small intestine in chronic pancreatitis has not been investigated yet thoroughly. It would be important to understand fat metabolism the course of this disease and could explained if some pathological conditions and, due reason, pancreatic enzyme substitution does work all patients.To investigate pathophysiology show reason why cases properly.In process study 33 patients have examined.The control group includes 30 subjects without similar for age, sex alcohol consumption with...
More than 70 drugs are known to induce pancreatitis. The frequency, clinical manifestations, and diagnosis of drug-induced pancreatitis that occurred during tuberculosis treatment have not been studied. In addition, the literature provides information regarding pancreatic toxicity certain anti-tuberculosis drugs. We examined 328 patients with pulmonary hepatitis treatment. Prior our observation, 92 (28.0%) abused alcohol, so chronic had a combined etiology, i.e., it due toxic effect on liver...
Vasyl Parmenovich Obraztsov (1849 — 1920) was an outstanding therapist, Professor of Medicine, and innovator in the field techniques for diagnosing diseases cardiovascular digestive systems. The research interests V. P. were mainly focused on studying most important issues general specific gastroenterology cardiology. At same time, he aimed to invent reliable physical diagnosis abdominal organs heart.
 Palpation organs, invented introduced into clinical practice by Obraztsov, is based...
In his doctoral thesis, young M. D. Strazhesko described a number of important physiological patterns in the activity dog’s intestines. was one first authors world literature to present information about nature juice different parts colon, especially caecum. At same time, attention drawn another new question specific sensitivity intestinal mucosa. «The mucous membrane at end small intestine is very from large intestine», he noted. «While mucosa former has high sensitivity, colon not...
Physiological features of amylase synthesis and excretion are considered in the article, presence other sources different from pancreas salivary glands is emphasized. Definitions hyperenzymemia macroamylasemia (MAE) given. MAE a state characterized by circulating complexes normal serum with protein or carbohydrates blood. There 3 types MAE: first — classical (constant hyperamylasemia, decreased level urine, high blood concentration macroamylase complexes); second hyperamylasemia slightly...
The article presents a complex clinical case of drug‑induced erosive esophagitis grade C with the formation Schatzki ring in patient S., 85 years old. A feature under consideration is long‑term persistence both esophageal (dysphagia, odynophagia) and extraesophageal (thoracalgia) complaints, which required an extensive differential diagnosis to rule out cardiac genesis pain syndrome. diagnostic search was complicated by patient’s advanced age, presence serious accompanying somatic pathology,...
Olexander Oleksiyovych Shalimov (1918—2006), Academician of the Academy Sciences Ukrainian SSR, Hero Socialist Labor, laureate State Awards USSR and an Honorary Doctor RSFSR, Scientist a famous Soviet scientist surgeon. He made great contribution to development scientific practical surgery training highly qualified personnel.The years spent working in Kharkiv marked beginning O. Shalimov’s career. The range his research interests was unusually wide covered digestive organs, heart, main...
Gastroenterology was the primary focus of O. Ya. Gubergrits’ scientific activity. He very interested in pancreatic pathology, described pain point pathology organ’s tail, and investigated functional condition pancreas a variety internal diseases. Numerous works are dedicated to diseases liver biliary system. Gubergrits potential therapeutic use non‑drug remedies, including local natural resources such as medicinal plants mineral waters. These topics covered monographs «Medicinal Plants...
Nina Fedorivna Deyneko is a Doctor of Medical Sciences, Professor, an honored worker science and technology Ukraine, outstanding health care worker, labor veteran, academician the International Academy Sciences in apiphytotherapy beekeeping. Under Prof. N. F. Deyneko’s supervision, 86 clinical residents, including 34 foreign ones, postgraduate students were taught during her tenure at Kharkiv departments therapy gastroenterology. Additionally, 25 candidate dissertations one doctorate thesis...
Endocrine pathology can lead to hepatic dysfunction and, conversely, liver disease endocrine dysfunction. The prevalence of metabolic associated steatotic (MASLD) and complications with the progression this have been rapidly increasing in recent decades. Lipid metabolism cholesterol synthesis depends on function feedback mechanisms. Therefore, it is necessary evaluate influence patients MASLD, treatment these conditions should be included complex traditional therapy. Liver adequate thyroid...