A5047807503- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Free Radicals and Antioxidants
- Systemic Sclerosis and Related Diseases
- Sunflower and Safflower Cultivation
- Lymphatic System and Diseases
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Electrochemical Analysis and Applications
- Gout, Hyperuricemia, Uric Acid
- Computer Graphics and Visualization Techniques
- 3D Shape Modeling and Analysis
- Essential Oils and Antimicrobial Activity
- Diagnosis and Treatment of Venous Diseases
- Biosensors and Analytical Detection
- Peptidase Inhibition and Analysis
- Legume Nitrogen Fixing Symbiosis
- bioluminescence and chemiluminescence research
- Mobile Agent-Based Network Management
- Analytical Chemistry and Sensors
- Neuropeptides and Animal Physiology
- Protein Hydrolysis and Bioactive Peptides
- Diet, Metabolism, and Disease
- Phytochemicals and Antioxidant Activities
China Tobacco
2025
Jilin Agricultural University
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Wenzhou Medical University
2024
Jilin University
2013-2024
Guangzhou Vocational College of Science and Technology
2024
Philips (China)
2022
Jilin Medical University
2010-2021
Shanghai Ninth People's Hospital
1985-2021
Shanghai Jiao Tong University
2021
The purpose of this study was to investigate the appropriate proportion Caco-2 and HT29 co-culture in vitro cell models for permeability studies. results showed that transepithelial electrical resistance values 9:1 1:0 groups (263 ± 3.61 300 7.55) after 21-day culture were >250 Ω cm2, which suitable further experiments. confocal laser microscopy group (Caco-2:HT29) had highest integrity, whereas 0:1 exhibited lowest. staining confirmed mucus successfully produced by cells, it also...
Sap is driven through phloem sieve tubes by an osmotically generated pressure gradient between source and sink tissues. In many plants, results from thermodynamically active loading in which energy used to transfer sucrose (Suc) mesophyll cells the of leaf minor veins against a concentration gradient. However, some species, almost all trees, correlative evidence suggests that sugar migrates passively plasmodesmata into elements. The possibility alternate mechanisms has important...
Xanthine oxidase (XO), which can catalyze the formation of xanthine or hypoxanthine to uric acid, is most important target gout. To explore conformational changes for inhibitor binding, molecular dockings and dynamics simulations were performed. Docking results indicated that three inhibitors had similar pose binding XO. Molecular showed influenced secondary structure in After inhibitor, peptide Phe798-Leu814 formed different degrees unhelix, while Glu1065-Ser1075, only a partial helix...
Sunflower (Helianthus annuus L.) contains active ingredients, such as flavonoids, alkaloids and tannins. Nevertheless, few studies have focused on essential oil from the receptacle of sunflower (SEO). In this work, we investigated chemical composition antimicrobial antioxidant activities SEO. The yield SEO was about 0.42% (v/w) by hydrodistillation. A total 68 volatile components were putatively identified gas chromatography–mass spectrometry (GC-MS). main constituents α-pinene (26.00%),...
Starch and cellulose are pivotal determinants of tobacco quality. In this work, starch in flue-cured leaf were extracted through a sequential extraction process. First, an aqueous solution leaves was prepared, by boiling the water. The precipitate separated, within it hydrolyzed using sulfuric acid solution. Then, content quantified colorimetric reaction with iodine solution, while determined anthrone as chromogenic agent. conditions optimized to ensure accuracy, recovery rate relative...
Benefits of a transtheoretical model-based exercise program on adherence (primary outcome) and secondary outcomes (self-efficacy, decisional balance, knee osteoarthritis symptoms, physical function) were assessed among older adults with osteoarthritis.A two-arm, superiority, assessor-blinded, cluster randomized trial randomization at the community level.Participants recruited from 14 communities in Beijing between April - October 2018 (N = 189). The intervention was 24-week control group...
Although antibodies and aptamers are commonly used bioaffinity recognition elements, they not available for many important analytes. As an alternative, we demonstrate use of a periplasmic binding protein (PBP) to provide high affinity thiamine (vitamin B1), analyte great importance human environmental health which, like so other small molecules, no suitable biorecognition element is available. We that with appropriate competitive strategy, highly sensitive (limit detection 0.5 nM) specific...
There are multiple drugs for the treatment of type 2 diabetes, including traditional sulfonylureas biguanides, glinides, thiazolidinediones, α-glucosidase inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase IV (DPP-4) and sodium-glucose cotransporter (SGLT2) inhibitors. α-Glucosidase inhibitors have been used to control postprandial glucose levels caused by diabetes since 1990. α-Glucosidases rather crucial in human metabolic system principally found families...
Here we report the draft genome sequence of one Acinetobacter genomic species 3 strain, D499, which harbors bla(NDM-1) gene. The total length assembled is 4,103,824 bp, and 3,896 coding sequences (CDSs) were predicted within genome. A previously unreported bla(NDM-1)-bearing plasmid was identified in this strain.
This study was focused on extraction, radical scavenging activities, and chemical composition identification of total flavonoids in sunflower (Helianthus annuus L.) receptacles (TFSR). We investigated the optimal extract parameters TFSR using response surface methodology. The highest yield 1.04% with ethanol concentration 58%, material-to-liquid ratio 1:20 (v/w), extraction time 2.6 h, temperature 67 °C. results activities showed that ethyl acetate fraction (EAF) strongest by...
Angiotensin-converting enzyme (ACE)-inhibitory peptides extracted from food proteins can lower blood pressure by inhibiting ACE activity. A recent study showed that the inhibitory activity of IY (Ile-Tyr, a dipeptide derived soybean protein) against was much higher than LL (Leu-Leu), although they had similar hydrophobic and predicted values. It difficult to reveal deep molecular mechanism underlying this phenomenon traditional experimental methods. The Apo two complex systems (i.e., ACE-LL...
Bromodomain and extra-terminal domain (BET) subfamily is the most studied of bromodomain-containing proteins (BCPs) family which can modulate acetylation signal transduction produce diverse physiological functions. Thus, BET be treated as an alternative strategy for targeting androgen-receptor (AR)-driven cancers. In order to explore effect inhibitors binding BRD4 (the member family), four 150 ns molecular dynamic simulations were performed (free BRD4, Cpd4-BRD4, Cpd9-BRD4 Cpd19-BRD4)....
Sunflower (Helianthus annuus L.) is an appropriate crop for current new patterns of green agriculture, so it important to change sunflower receptacles from waste useful resource. However, there limited knowledge on the functions compounds essential oils receptacles. In this study, a method was created chemical space network analysis and classification small samples, applied 104 compounds. Here, t-SNE (t-Distributed Stochastic Neighbor Embedding) dimensions were used reduce coordinates as...
The dried rattan stem of the Fibraurea Recisa Pierre plant contains active ingredient known as
The segmentation of pulmonary lobes is important in clinical assessment, lesion location, and surgical planning. Automatic lobe challenging, mainly due to the incomplete fissures or morphological variation resulting from lung disease. In this work, we propose a learning-based approach that incorporates information local fissures, whole lung, priori anatomy knowledge separate robustly accurately. prior atlas registered test CT images with aid detected fissures. result obtained by mapping...