A5072593295- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- RNA modifications and cancer
- DNA and Nucleic Acid Chemistry
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
Ben-Gurion University of the Negev
2018-2023
Abstract Pediatric malignancies including Ewing sarcoma (EwS) feature a paucity of somatic alterations except for pathognomonic driver-mutations that cannot explain overt variations in clinical outcome. Here, we demonstrate EwS how cooperation dominant oncogenes and regulatory germline variants determine tumor growth, patient survival drug response. Binding the oncogenic EWSR1-FLI1 fusion transcription factor to polymorphic enhancer-like DNA element controls expression MYBL2 mediating these...
Medulloblastoma is the most common malignant brain cancer in children. Since previous studies have mainly focused on alterations coding genome, our understanding of contribution long noncoding RNAs (lncRNAs) to medulloblastoma biology just emerging. Using patient-derived data, we show that promoter lncRNA TP73-AS1 hypomethylated and transcript highly expressed SHH subgroup. Furthermore, high expression correlated with poor outcome patients TP53 wild-type tumors. Silencing tumor cells induced...
Abstract Members of the conserved Pif1 family 5′-3′ DNA helicases can unwind G4s and mitigate their negative impact on genome stability. In Saccharomyces cerevisiae, two members, Rrm3, contribute to suppression genomic instability at diverse regions including telomeres, centromeres tRNA genes. While resolve lagging strand in vivo, little is known regarding Rrm3 function its cooperation with for G4 replication. Here, we monitored replication through sequences real time show that essential...
INTRODUCTORY PARAGRAPH Deciphering principles of inter-individual tumor heterogeneity is essential for refinement personalized anti-cancer therapy. Unlike cancers adulthood, pediatric malignancies including Ewing sarcoma (EwS) feature a striking paucity somatic alterations except pathognomonic driver-mutations that cannot explain overt variations in clinical outcome. Here we demonstrate the EwS model how cooperation dominant oncogene and regulatory variants determine growth, patient survival...