A5100379344- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Asthma and respiratory diseases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Chronic Kidney Disease and Diabetes
- Immune cells in cancer
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Arrest and Resuscitation
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Nuclear Receptors and Signaling
- Kruppel-like factors research
- Hydrogen's biological and therapeutic effects
- IgG4-Related and Inflammatory Diseases
- Marriage and Family Dynamics
- Pulmonary Hypertension Research and Treatments
- Bioactive Compounds and Antitumor Agents
National University of Singapore
2025
Agency for Science, Technology and Research
2019-2025
Hainan Medical College Hospital
2024
First Affiliated Hospital of Jinan University
2017-2023
People's Liberation Army No. 150 Hospital
2023
Army Medical University
2022
Southwest Hospital
2022
Wenzhou Medical University
2022
Zhejiang Taizhou Hospital
2022
First Affiliated Hospital of Fujian Medical University
2020-2021
Abstract Pulmonary fibrosis is a serious lung disorder that can lead to respiratory failure. Here we show transgenic mice expressing active renin from the liver (RenTgMK) developed progressive pulmonary leading impaired function. Histological analyses revealed marked increase in extracellular matrix (ECM) deposition and decrease alveolar size lungs of RenTgMK compared wild-type (WT) littermates, accompanied with increased expression ECM proteins fibrogenic factors. The led substantial system...
Primary pulmonary choriocarcinoma (PPC) is a highly malignant intrapulmonary tumor with notorious prognosis. Few clinical studies have been undertaken to investigate the characteristics and prognosis of PPC.We systematically conducted retrospective analysis patients PPC in literature published PubMed CNKI databases until March 31, 2022. The primary outcome was all-cause mortality. Survival curves were depicted using Kaplan‒Meier method compared stratified log-rank test. A Cox proportional...
Preterm birth (PTB), defined as child before completion of 37 weeks gestation, is a major challenge in perinatal health care and can bear long-term medical financial burden. Over million children die each year due to PTB complications, those who survive face developmental delays. Unfortunately, our understanding the molecular pathways associated with remains limited. There growing body evidence suggesting role DNA methylation (DNAm) mediating effects on future outcomes. Thus, epigenome-wide...
Although the associations between cord blood lipidome and neonatal birth weight are established, it remains uncertain whether sexual dimorphism in fetal fat accumulation extends to relationship lipid profiles abdominal compartments. Understanding these relationships could provide insights into early sex-specific differences metabolism. We conducted lipidomics of umbilical plasma samples (350 (46.6%) girls 401 (53.4%) boys) from Growing Up Singapore Towards healthy Outcomes (GUSTO) cohort....
Acute traumatic coagulopathy (ATC) is an extremely common but silent murderer; this condition presents early after trauma and impacts approximately 30% of severely injured patients who are admitted to emergency departments (EDs). Given that conventional coagulation indicators usually require more than 1 hour admission yield results-a limitation frequently prevents the ability for clinicians make appropriate interventions during optimal therapeutic window-it clearly vital importance develop...
Background: Acute aorta dissection (AD) is a fatal emergency, however, studies addressing the clinical characteristics, management, and outcome of acute AD in young adult patients aged under 45 years China are very few.Methods: A retrospective study including 490 with as final diagnosis was conducted. Patients' demographics, medical history, laboratory diagnostic imaging findings were retrieved from records. Results: The median age 38 old an interquartile range 33 to 41. Male smoker...
Impulse oscillometry (IO) is a non-invasive pulmonary function test for measuring respiratory impedance. Available reference equations of IO indices adults are limited. The aim this study was to develop Chinese adults.In multicentral, cross-sessional in adults, data from healthy subjects were collected 19 general hospitals across China between 2016 and 2018. Oscillometry measurements conducted accordance with recommendations the European Respiratory Society (ERS). Multiple linear regression...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) result in high mortality, whereas effective treatments are limited. Methionine restriction (MR) has been reported to offer various benefits against multiple pathological processes of organ injuries. However, it remains unknown whether MR any potential therapeutic value for ALI/ARDS. The current study was set investigate the on lipopolysaccharide (LPS)-induced ALI its underlying mechanisms. We found that attenuated...
Acute respiratory distress syndrome (ARDS) is a leading cause of failure, with substantial attributable morbidity and mortality. The small animal models that are currently used for ARDS do not fully manifest all the pathological hallmarks human patients, which hampers both studies disease mechanism drug development. To examine whether phenotypic changes primate-like tree shrews in response to one-hit lipopolysaccharides (LPS) injury resemble features. LPS was administered through...
To investigate the effect of high-flow nasal cannula (HFNC) and Oxygen Nebuliser mask (ONM) on patients recovering from inhalation anesthesia.A retrospective analysis was performed 128 after general anesthesia in recovery room Anesthesiology Department The Fourth Hospital Hebei Medical University September 2019 to 2021. All received same induction analgesia methods, or intravenous-inhalation maintenance, recovered spontaneous breathing removed endotracheal intubation surgery, then were...
This study evaluated the effectiveness of individualized dietary interventions in improving nutritional status and general health individuals undergoing dialysis. A total 120 patients dialysis were equally allocated to Standard Care Group Intervention Group. The recipients counseling had their plans modified monthly accordance with needs, personal preferences, clinical circumstances. Nutritional adherence, biochemical parameters, outcomes, quality life compared between groups. At baseline,...
Abstract The photoenolization/Diels-Alder sequence provides a direct preparation of quinone 2 which exhibited activity against SR leukemia and colon cancers.
Krüppel-like factor 17 (KLF17) has been reported to be involved in invasion and metastasis suppression lung cancer, but the molecular mechanisms underlying anti-invasion anti-metastasis roles of KLF17 cancer are not fully illustrated. Here, we showed that inhibited A549 H322 cells; effect was associated with urokinase plasminogen activator (uPA/PLAU) expression. can bind promoter uPA inhibit its Enforced expression abrogated cells. In addition, immunohistochemistry staining protein...
Background International data suggest that people with diabetes mellitus (DM) are at increased risk for worse acute kidney injury (AKI) outcomes; however, the in China limited. Therefore, this study aimed to describe association of DM short-term prognosis, length stay, and expenditure patients AKI. Methods This was based on 2013 nationwide survey China. According 2012 Kidney Disease: Improving Global Outcomes (KDIGO) expanded criteria AKI, 7604 AKI were identified, 1404 6200 without DM,...
Acute respiratory distress syndrome (ARDS) is a common cause of death in ICU patients and its underlying mechanism remains unclear, which leads to high mortality rate. This study aimed identify candidate genes potentially implicating the pathogenesis ARDS provide novel therapeutic targets.Using bioinformatics tools, we searched for differentially expressed (DEGs) an microarray dataset downloaded from Gene Expression Omnibus (GEO) database. Afterwards, functional enrichment analysis GO, KEGG,...
Case PresentationA 52-year-old man was referred to our hospital for cough, fever, chest pain, and progressive dyspnea. He has worked as a full-time security staff at community center in normal state of health until 11 months prior referral when he began experiencing expectoration, high-grade fever (up 39.7°C), chills, left pain. visited the local several times with suspected lung cancer. Bronchoscopy showed chronic inflammatory changes his bronchi. given course antibiotics, but had not...
Objective: This study aimed to explore the effectiveness of sodium bicarbonate (SB) administration on mortality in septic patients with acute moderate lactic acidosis (MLA). Methods: The large ICU database (MIMIC-IV) was retrospectively analyzed. Patients sepsis and MLA were identified. Propensity score analysis (PSA) performed explain baseline differences probability accepting or not SB. edge structured cox model (MSCM) used adjust for time-varying confounding variables. primary outcome...
Acute kidney injury (AKI) is one of the common complications pulmonary infections. However, nomograms predicting risk early-onset AKI in patients with infections have not been comprehensively researched. In this study, 3278 infection were extracted from Medical Information Mart for Intensive Care III (MIMIC-III) database. These randomly divided into training and validation cohorts, cohort used model building validation. Independent factors determined using least absolute shrinkage selection...
Patients with critical coronavirus disease 2019 (COVID-19), characterized by respiratory failure requiring mechanical ventilation (MV), are at high risk of mortality. An effective and practical MV weaning protocol is needed for these fragile cases.Here, we present two COVID-19 patients who presented fever, cough fatigue. diagnosis was confirmed based on blood cell counts, chest computed tomography (CT) imaging, nuclei acid test results. To address the patients' failure, they first received...
Objective To examine the effect of body fat mass and distribution on pulmonary ventilatory function among adult females. Methods Based multistage cluster sampling principal,we selected 935 healthy females with ages 19-81 years old in Heilongjiang province to conduct study. Every 10-years as a age group. Firstly obtain basic situation through questionnaire survey,and then measure height, weight, waistline, hip circumference, composition lung function. FVC, FEV1, PEF, FEF25%, FEF50%, FEF75%...
Objectives. The aim of this study is to investigate the effect glucocorticoids in adult patients with acute respiratory distress syndrome (ARDS) by meta-analysis. Methods. PubMed, Cochrane Library, Embase, CNKI, Wanfang Database, and Chinese Biomedical literature database were searched. A randomized controlled trial (RCTS) on glucocorticoid therapy ARDS was conducted from time construction December 2021. content about (RCT) treatment for ARDS, without limiting dose course treatment. quality...
Abstract Background: Impulse oscillometry (IOS) is a non-invasive pulmonary function test for measuring respiratory impedance. Available reference equations of IOS indices adults are limited. The aim this study was to develop Chinese adults. Methods: In multicentral, cross-sessional impulse in adults, data from healthy subjects were collected 19 general hospitals across China between 2016 and 2018. measurements conducted accordance with recommendations the European Respiratory Society....