A5049631280- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Immune cells in cancer
- Long-Term Effects of COVID-19
- Single-cell and spatial transcriptomics
- Diabetes and associated disorders
- Phagocytosis and Immune Regulation
- Nanoparticle-Based Drug Delivery
- Engineering Education and Curriculum Development
- Military History and Strategy
- RNA Interference and Gene Delivery
- Pediatric Hepatobiliary Diseases and Treatments
- Whipple's Disease and Interleukins
- Defense, Military, and Policy Studies
- Organizational Learning and Leadership
- Management and Marketing Education
- Galectins and Cancer Biology
- Clinical Nutrition and Gastroenterology
University of Birmingham
2015-2023
Institute of Immunology
2021
Imperial College London
2020-2021
King's College London
2017-2018
Background & AimsMucosal-Associated Invariant T (MAIT) cells are innate-like characterised by the invariant TCR-chain, Vα7.2-Jα33, and restricted MR1, which presents bacterial vitamin B metabolites. They important for antibacterial immunity at mucosal sites; however, detailed characteristics of liver-infiltrating MAIT (LI-MAIT) their role in biliary immune surveillance remain unexplored.MethodsThe phenotype intrahepatic localisation human LI-MAIT was examined diseased normal livers. cell...
Intestinal immune homeostasis is dependent upon tightly regulated and dynamic host interactions with the commensal microbiota. Immunoglobulin A (IgA) produced by mucosal B cells dictates composition of bacteria residing within intestine. While emerging evidence suggests majority IgA innately may be polyreactive, mucosal-dwelling species can also elicit via T cell–dependent mechanisms. However, mechanisms that modulate magnitude quality responses remain incompletely understood. Here we...
Innate lymphoid cells recirculate through peripheral lymph nodes and contribute to early IFN-γ production after immunization.
End-stage kidney disease (ESKD) patients are at high risk of severe COVID-19. We measured 436 circulating proteins in serial blood samples from hospitalised and non-hospitalised ESKD with COVID-19 (n = 256 55 patients). Comparison to 51 non-infected revealed 221 differentially expressed proteins, consistent results a separate subcohort 46 patients. Two hundred three were associated clinical severity, including IL6, markers monocyte recruitment (e.g. CCL2, CCL7), neutrophil activation...
The lymph node (LN) is home to resident macrophage populations that are essential for immune function and homeostasis, but key factors controlling this niche undefined. Here, we show fibroblastic reticular cells (FRCs) an component of the LN niche. Genetic ablation FRCs caused rapid loss macrophages monocytes from LNs across two in vivo models. Macrophages co-localized with human LNs, murine single-cell RNA-sequencing revealed FRC subsets broadly expressed master regulator CSF1. Functional...
<ns4:p><ns4:bold>Background</ns4:bold>: Innate lymphoid cells (ILCs) have now been identified within most tissues of the body and current evidence indicates that this family play a fundamental role in maintaining tissue homeostasis. However, few studies compared ILC populations between several tissues.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: We sought to generate comprehensive characterisation different C57BL/6 WT genetically modified mice targeting costimulatory pathways, using...
<ns4:p><ns4:bold>Background</ns4:bold>: Innate lymphoid cells (ILCs) have now been identified within most tissues of the body and current evidence indicates that this family play a fundamental role in maintaining tissue homeostasis. However, few studies compared ILC populations between several tissues.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: We sought to generate comprehensive characterisation different C57BL/6 WT genetically modified mice targeting costimulatory pathways, using...
Abstract The OX40-OX40L pathway provides crucial co-stimulatory signals for CD4 T cell responses, however the precise cellular interactions critical OX40L provision in vivo and when these occur, remains unclear. Here, we demonstrate that of by dendritic cells (DCs), but not cells, B nor group 3 innate lymphoid (ILC3s), is specifically effector Th1 response to an acute systemic infection with Listeria monocytogenes (Lm). expression DCs regulated cross-talk NK IFNγ signalling DC enhance a...
The thymic medulla is critical for the enforcement of central tolerance. In addition to deletion auto-reactive T-cells, supports maturation heterogeneous natural αβT-cells linked tolerance mechanisms. Natural IL-17-secreting CD4(+)αβT-cells (nTh17) represent recently described that mature and undergo functional priming intrathymically. Despite a proposed potential impact upon either protective or pathological inflammatory responses, intrathymic mechanisms regulating balance nTh17 development...
Several different memory T‐cell populations have now been described based upon surface receptor expression and migratory capabilities. Here we assessed murine endogenous CD4 + T cells generated within a draining lymph node their subsequent migration to other secondary lymphoid tissues. Having established model response targeting specific peripheral node, temporally labelled all the using photoconversion. Tracking of photoconverted non‐photoconverted Ag‐specific revealed rapid establishment...
Abstract End-stage kidney disease (ESKD) patients are at high risk of severe COVID-19. We measured 436 circulating proteins in serial blood samples from hospitalised and non-hospitalised ESKD with COVID-19 (n=256 55 patients). Comparison to 51 non-infected revealed 221 differentially expressed proteins, consistent results a separate subcohort 46 patients. 203 were associated clinical severity, including IL6, markers monocyte recruitment (e.g. CCL2, CCL7), neutrophil activation proteinase-3)...
<ns4:p><ns4:bold>Background</ns4:bold>: Innate lymphoid cells (ILCs) have now been identified within most tissues of the body and current evidence indicates that this family play a fundamental role in maintaining tissue homeostasis. However, few studies compared ILC populations between several tissues.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: We sought to generate comprehensive characterisation different C57BL/6 WT genetically modified mice targeting costimulatory pathways, using...
Summary The lymph node (LN) is home to resident macrophage populations that are essential for immune function and homeostasis. T cell paracortical zone a major site of efferocytosis apoptotic cells, but key factors controlling this niche undefined. Here we show fibroblastic reticular cells (FRCs) an component the LN niche. Macrophages co-localised with FRCs in human LNs, murine single-cell RNA-sequencing revealed most expressed master regulator CSF1. Functional assays showed CSF1R signalling...
What manufacturing leaders can learn from their military counterparts
The lymph node (LN) is home to resident macrophage populations that are essential for immune function and homeostasis. T cell paracortical zone a major site of efferocytosis apoptotic cells, but key factors controlling this niche undefined. Here we show fibroblastic reticular cells (FRCs) an component the LN niche. Macrophages co-localised with FRCs in human LNs, murine single-cell RNA-sequencing revealed most expressed master regulator CSF1. Functional assays showed CSF1R signalling was...