A5103130173- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Tryptophan and brain disorders
- Lipoproteins and Cardiovascular Health
- Congenital heart defects research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Salivary Gland Disorders and Functions
- Medical Research and Treatments
- Pregnancy and preeclampsia studies
- Vitamin D Research Studies
- Galectins and Cancer Biology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- GDF15 and Related Biomarkers
- Eosinophilic Disorders and Syndromes
- Cancer-related cognitive impairment studies
- Acute Myeloid Leukemia Research
- Lipid metabolism and disorders
- Cardiac Health and Mental Health
- S100 Proteins and Annexins
- Diabetes Treatment and Management
- MicroRNA in disease regulation
General Hospital of Shenyang Military Region
2021-2025
Shenyang Pharmaceutical University
2022-2023
Zhejiang Chinese Medical University
2019
Tang Hospital
2015
Endothelial cell dysfunction contributes to age-related vascular diseases. Analyzing public databases and mouse tissues, we found decreased MFN2 expression in senescent endothelial cells angiotensin II-treated aortas. In human cells, Ang II reduced while increasing senescence markers P21 P53.
Objective This study aimed to evaluate the impact of systemic inflammation burden using high-sensitivity C-reactive protein (hsCRP) and long-term prognosis in acute coronary syndrome (ACS) patients undergoing percutaneous intervention (PCI) stratified by bleeding risk status. Methods Consecutive admitted for ACS who received PCI between March 2016 2022 were enrolled analysis. Elevated was defined as hsCRP>2 mg/L, high (HBR) Academic Research Consortium (ARC)-HBR criteria. The primary...
To evaluate the effectiveness and safety of ticagrelor versus clopidogrel in patients with acute coronary syndromes (ACS) undergoing complex percutaneous intervention (PCI).It remains inconclusive whether is superior to ACS PCI real-world practice.Based on an all-comers registry, we compared long-term between PCI, defined as procedures for lesions including bifurcation, chronic total occlusion, ostial, tortuous, calcific, diffused, thrombus-containing, restenotic lesions. The primary...
The occurrence of cardiovascular adverse events in the first year after ST-acute myocardial infarction (STEMI) remains high; therefore, identification patients with poor prognosis is essential for early intervention. This study aimed to evaluate prognostic value metabolomics-based biomarkers STEMI and explore their functional mechanisms.Metabolite profiling was performed using nuclear magnetic resonance. plasma concentration Kynurenine (Kyn) measured ultraperformance liquid...
Optimal anticoagulants for patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention (PCI) are unclear. This retrospective observational study is aimed at evaluating efficacy and safety of bivalirudin versus unfractionated heparin (UFH) monotherapy in DM PCI. A total 3890 diabetic receiving PCI the General Hospital Northern Theater Command were divided into group (n = 869) UFH 3021) according to different anticoagulant therapy regimens. Indication was accordance...
To explore the impact of 6- versus 12-month dual antiplatelet therapy (DAPT) on clinical prognosis high bleeding risk (HBR) patients.The optimal DAPT duration after percutaneous coronary intervention (PCI) in HBR patients is unclear.This study a post hoc analysis 4-year follow-up results I LOVE IT 2 study. Prevalence and were explored, outcomes who underwent compared. The primary outcome was Bleeding Academic Research Consortium (BARC) type 3 or 5 bleeding. secondary BARC 2-5 net adverse...
Abstract Objective To assess the effectiveness and safety of bivalirudin compared with heparin monotherapy in elderly patients undergoing percutaneous coronary intervention (PCI). Background Bivalirudin is recommended for periprocedural use PCI who are high bleeding risk. However, its safe efficacious patients, a typical risk cohort, real world practice yet to be reported. Methods In this single center, real‐world observational study, 4736 consecutive underwent were enrolled. Of these, 1240...
The clinical benefit of ticagrelor vs. clopidogrel in unselected patients with acute coronary syndrome (ACS) after percutaneous intervention (PCI) remains controversial the real world. This study was aimed to investigate impact subjects ACS without atrial fibrillation or flutter (AF) PCI based on risk stratification using CHA2DS2-VASc score. In 2016-2019, who underwent at least one stent implanted General Hospital Northern Theater Command were classified as low- high-risk groups according...
In current clinical practice, controversy remains regarding the benefits of prolonged dual antiplatelet therapy (DAPT) in acute coronary syndrome (ACS) patients facing high risks both ischemia and bleeding ("bi-risk") following percutaneous intervention (PCI). This study aimed to investigate feasibility identifying a group bi-risk ACS after PCI using OPT-BIRISK criteria, emphasizing extended DAPT treatment safety efficacy beyond 12 months these real-world conditions.This analysis compared...
Abstract Both primary Sjögren’s syndrome (pSS) and acute myocardial infarction (AMI) are intricately linked. However, their common mechanism is not fully understood. Herein, we examined the underlying network of molecular action associated with developing this complication. Datasets were downloaded from GEO database. We performed enrichment protein–protein interaction analyses screened key genes. used external datasets to confirm diagnostic performance for these hub Transcription factor...
Backgrounds: A plug-and-play standardized algorithm to identify the ischemic risk in patients with coronary artery disease (CAD) undergoing percutaneous intervention (PCI) could play a valuable step help wide spectrum of clinic workers. This study intended investigate ability use accumulation multiple clinical routine scores predict long-term events CAD PCI. Methods: was secondary analysis I-LOVE-IT 2 (Evaluate Safety and Effectiveness Tivoli drug-eluting stent (DES) Firebird DES for...
This study aimed at comparing the effectiveness and safety of ticagrelor clopidogrel in acute coronary artery syndrome (ACS) patients stratified by Optimal Antiplatelet Therapy for Chinese Patients with Coronary Artery Disease (OPT-CAD) risk score.Although they provide a promising basis treatment decisions, scores have not been utilized to optimize P2Y12 inhibitors ACS patients.In 2016-2019, 16,343 who underwent percutaneous intervention General Hospital Northern Theater Command were...
Nonsteroidal anti‐inflammatory drug‐activated gene (NAG‐1) or growth differentiation factor 15 (GDF15) is a divergent member of the transforming beta (TGF‐β) superfamily. Mice expressing NAG‐1/GDF15 have been shown to be resistant high fat diet (HFD)‐induced obesity and inflammation. However, exact mechanism underlying anti‐obesity effects remains unknown. The objective this study was examine whether associated with gut microbiota modulation barrier function regulation. First, we confirmed...
Objective To investigate the effects of Ruangan granule on transforming growth factor-β1(TGF-β1)/Smads signaling pathway in liver fibrosis rats. Methods A total 105 Wistar rats were randomly divided into normal control group, model group and colchicine, Dahuang-Zhechong pill high-, medium- low-dose groups (n=15 each group). Liver was induced by carbon tetrachloride a high-cholesterol diet. After modeling, low-, high-dose intragastric administrated mixed suspension 3.6, 7.2, 14.4...
This study evaluated clinical outcomes of switching from clopidogrel to ticagrelor in patients with acute coronary syndrome (ACS) undergoing percutaneous intervention (PCI). The benefit in-hospital these remains unclear. Among ACS initially receiving clopidogrel, logistic regression was used identify independent predictors ticagrelor. Multivariable Cox compare efficacy and safety between continuing clopidogrel. primary endpoint net adverse events (NACEs) at 12 months, a composite major...