A5056343925- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Hormonal Regulation and Hypertension
- SARS-CoV-2 and COVID-19 Research
- Nitric Oxide and Endothelin Effects
- Sodium Intake and Health
- Renal and Vascular Pathologies
- Angiogenesis and VEGF in Cancer
- Eicosanoids and Hypertension Pharmacology
- COVID-19 and healthcare impacts
- Pituitary Gland Disorders and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- COVID-19 and Mental Health
- Heme Oxygenase-1 and Carbon Monoxide
- Retinal Imaging and Analysis
- Adipose Tissue and Metabolism
- Renin-Angiotensin System Studies
- Hemoglobin structure and function
- Acute Ischemic Stroke Management
- Peripheral Artery Disease Management
- Heart Rate Variability and Autonomic Control
University of Brescia
2006-2023
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2003-2023
Medica (Italy)
2005-2010
Fundación Juan March
2007
North Carolina Central University
2005
Wake Forest University
2005
Medical College of Wisconsin
2005
The presence of structural alterations in the microcirculation may be considered an important mechanism organ damage; however, it is not currently known whether small arteries predict fatal and nonfatal cardiovascular events.One hundred twenty-eight patients were included present study. There 59 with essential hypertension, 17 pheochromocytoma, 20 primary aldosteronism, 12 renovascular normotensive non-insulin-dependent diabetes mellitus. All subjects submitted to a biopsy subcutaneous fat....
Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain.
Structural alterations in the microcirculation may be considered an important mechanism of organ damage. An increased tunica media to internal lumen ratio subcutaneous small-resistance arteries (M:L) predict development cardiovascular events a high-risk population. However, it is not known whether structural small also major events.Three hundred three subjects were included present study. There 65 normotensive subjects, 111 patients with essential hypertension (33% them diabetes mellitus),...
Objective Structural alterations in the microcirculation may be considered an important mechanism of organ damage. An increased media-to-lumen ratio subcutaneous small resistance arteries has been demonstrated to predict development cardiocerebrovascular events hypertensive patients. Alterations structure cerebral have animal models experimental or genetic hypertension. However, no evaluation with reliable techniques ever performed humans. Design and methods Twenty-eight participants were...
Structural alterations of subcutaneous small resistance arteries are associated with a worse clinical prognosis in hypertension and noninsulin-dependent diabetes mellitus (NIDDM). However, no data presently available about the effects antihypertensive therapy on vascular structure hypertensive patients NIDDM. Therefore, we have investigated effect an angiotensin-converting enzyme inhibitor, enalapril, highly selective angiotensin receptor blocker, candesartan cilexetil, indices artery 15...
Context and Objective: It has been previously demonstrated that aldosterone may possess a strong profibrotic action in vitro animal models of genetic or experimental hypertension. Our aim was to evaluate whether such is present also the human microcirculation. Design Patients: We investigated 13 patients with primary aldosteronism, seven essential hypertension, 10 normotensive controls. All subjects were submitted biopsy gluteal sc fat tissue. Small resistance arteries dissected mounted on...
Structural alterations of subcutaneous small resistance arteries, as indicated by an increased media:lumen ratio, are frequently present in hypertensive and/or diabetic patients and may represent the earliest alteration observed. In addition, ratios arteries have a strong prognostic significance. However, no data available about structure obese patients, particularly after weight loss. We investigated 27 with severe obesity. Twelve them were normotensive, 15 hypertensive. All underwent...
Abstract The aim of the present study was to simultaneously assess several potential predictors outcome (co-morbidity, previous and in-hospital treatment, radiologic Brixia score) in patients with COVID-19. This retrospective cohort included 258 consecutive confirmed COVID-19 admitted a medical ward at Montichiari Hospital, Brescia, Italy from February 28th April 30rd, 2020. Patients had SARS-CoV-2 related pneumonia respiratory failure, were treated hydroxychloroquine lopinavir plus...
Abstract Coronavirus disease 2019 (COVID-19) represents a major health problem in terms of deaths and long-term sequelae. We conducted retrospective cohort study at Montichiari Hospital (Brescia, Italy) to better understand the determinants outcome two different COVID-19 outbreaks. A total 634 unvaccinated patients admitted from local emergency room Internal Medicine ward with confirmed diagnosis SARS-CoV-2 infection moderate-to-severe were included study. group 260 consecutive during first...
Structural alterations of small resistance arteries in patients with essential hypertension (EH) are mostly characterized by inward eutrophic remodeling. However, we have observed the presence hypertrophic remodeling renovascular hypertension, as well noninsulin-dependent diabetes mellitus, suggesting a relevant effect humoral growth factors on vascular structure. Growth hormone may stimulate vitro proliferation smooth muscle cells. no data presently available about artery structure...
Objective: No data are presently available about changes in capillary density the skeletal muscle and brain of spontaneously hypertensive rats (SHR) relation to development hypertension. Design methods: We have investigated 4
It was suggested that oxidative stress has a key role in the development of endothelial dysfunction, as well microvascular structural alterations. Therefore, we have investigated 2 substances with antioxidant properties: melatonin and Pycnogenol. We treated 7 spontaneously hypertensive rats (SHRs) Pycnogenol for 6 weeks. compared results obtained those observed SHRs Wistar-Kyoto normotensive control kept untreated. Mesenteric small resistance arteries were dissected mounted on wire myograph,...
The aim of the study was to assess short-term consequences SARS-CoV-2-related pneumonia, also in relation radiologic/laboratory/clinical indices risk at baseline. This prospective follow-up cohort included 94 patients with confirmed COVID-19 admitted a medical ward Montichiari Hospital, Brescia, Italy from February 28th April 30th, 2020. Patients had related pneumonia respiratory failure. Ninety-four out 193 survivors accepted be re-evaluated after discharge, on average 4 months. In ¼ an...
Objectives It has been previously demonstrated that the morning rise (MoR) of blood pressure (BP) may predict major cardiovascular events in hypertensive patients. Structural alterations small resistance arteries, as evaluated by tunica media to internal lumen ratio (M/L) subcutaneous also events. Because an increased M/L amplify effect stimuli, present study aimed evaluate possible relationships between MoR and a population Methods Sixty-four patients with essential hypertension were...
Structural alterations of small resistance arteries in essential hypertensive patients (EH) are mostly characterized by inward eutrophic remodeling. However, we observed hypertrophic remodeling with renovascular hypertension, those acromegaly, as well non-insulin-dependent diabetes mellitus, suggesting a relevant effect humoral growth factors on vascular structure, even independent from the hemodynamic load. Cortisol may stimulate renin-angiotensin system and induce cardiac hypertrophy....
The main objective of this study was to compare the anti-hypertensive efficacy and safety nebivolol (5 mg once daily) lisinopril (20 given for 12 weeks in patients with mild moderate essential hypertension. Fourteen centres participated randomized, double-blind parallel group study. Sixty-eight uncomplicated mild-to-moderate hypertension were sixty-five eligible analysis (intention-to-treat). Hypertensive newly diagnosed, or previous antihypertensive therapy withdrawn at least 1 month before...
Background Vascular structural alterations in small resistance arteries of patients with essential hypertension (EH) are mostly characterized by inward eutrophic remodeling. In fact, no difference the smooth muscle cell volume (CV) between normotensive subjects (NT) and hypertensive was observed. However, experimental models chronic infusion agonists adrenergic receptors were presence hypertrophy or hyperplasia. Recently, we have observed vascular renovascular hypertension. Objective The aim...
Spontaneously hypertensive rats are an example of animal model genetic hypertension with insulin resistance. The aim this study was to investigate signaling in the heart and skeletal muscle spontaneously rats, as well evaluate effects renin-angiotensin system blockade.We investigated eight untreated 12 weeks age age-matched normotensive Wistar-Kyoto controls. In addition, were treated for 8 angiotensin receptor blocker olmesartan, angiotensin-converting enzyme inhibitor enalapril. a...
We have evaluated the effects of different doses an angiotensin-converting enzyme (ACE) inhibitor, enalapril (ENA) and angiotensin II type 1 receptor blocker olmesartan (OLM), on extracellular matrix heart, kidney, aorta mesenteric artery spontaneously hypertensive rats (SHR). Forty SHR eight Wistar-Kyoto controls (WKY) were included in study. Eight treated with high-dose OLM 15 mg/kg per day, ENA 25 low-dose day (2 day). WKY kept untreated as controls. Treatment was from age 4 to 12 weeks....
Objective The presence of endothelial dysfunction in the coronary circulation or brachial artery has been found to be associated with a greater incidence cardiovascular events. However, no data are presently available about prognostic role human small resistance arteries. Design and methods Ninety subjects were included present study. They were: 10 normotensive subjects, 36 patients essential hypertension, phaeochromocytoma, 11 primary aldosteronism, renovascular 13 non-insulin-dependent...
We have previously demonstrated that structural alterations in subcutaneous small resistance arteries of hypertensive patients, as indicated by an increased media to lumen ratio (M/L), are a potent predictor cardiovascular events, and close correlation exists between serum creatinine M/L. The aim the present study was assess whether M/L may predict subsequent changes renal function patients.Sixty participants (13 normotensive 47 patients) underwent biopsy fat. Resistance-sized were dissected...