A5101575179- Bacteriophages and microbial interactions
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Ocular Surface and Contact Lens
- Cancer-related molecular mechanisms research
- Phytochemistry and Bioactive Compounds
- Corneal Surgery and Treatments
- Nanoparticle-Based Drug Delivery
- Phagocytosis and Immune Regulation
- Retinal Diseases and Treatments
- Carcinogens and Genotoxicity Assessment
- Biochemical and Molecular Research
- MicroRNA in disease regulation
- bioluminescence and chemiluminescence research
- Enzyme Structure and Function
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- Wound Healing and Treatments
- Telomeres, Telomerase, and Senescence
- Geological and Geochemical Analysis
- Retinal Development and Disorders
- Bioactive Natural Diterpenoids Research
- Cancer-related Molecular Pathways
- Tannin, Tannase and Anticancer Activities
- Geochemistry and Geologic Mapping
Sun Yat-sen University
2004-2025
Taizhou People's Hospital
2023-2025
Nanjing Medical University
2023-2025
Nantong University
2023-2025
Zunyi Medical University
2025
Shenyang Pharmaceutical University
2019
Guangzhou University
2017
Tongue squamous cell carcinoma (TSCC), a subtype of head and neck carcinoma, is characterized by frequent chemoresistance. Genetic mutations commonly observed in TSCC play critical role malignant progression; thus, elucidating their functional significance essential for developing effective treatment strategies. To more accurately investigate the relationship between chemoresistance, we established low-passage cells, CTSC-1, obtained from chemoresistant patient, CTSC-2, treatment-naïve...
Colorectal cancer (CRC) is one of the most common cancers worldwide. Nowadays, owing to complex mechanism tumorigenesis, simultaneous inhibition multiple targets an important anticancer strategy. Recent studies have demonstrated receptor tyrosine kinase AXL (AXL) and histone deacetylase 2 (HDAC2) are closely associated with colorectal cancer. Herein, we identified five hit compounds concurrently targeting HDAC2 using virtual screening. Inhibitory experiments revealed these potently inhibited...
Abstract Background Aqueous-deficient dry eye disease (ADDED) resulting from dysfunction of the lacrimal gland (LG) is currently incurable. Although LG stem/progenitor cell-based therapy considered to be a promising strategy for ADDED patients, lack reliable serum-free culture method obtain enough stem cells (LGSCs) and basic standard LGSC transplantation are obstacles further research. Methods Adult mouse LGSCs were cultured in Matrigel-based 3D under condition, which contained EGF, FGF10,...
Abstract Breast cancer is one of the most common cancers diagnosed among women worldwide. Estrogen receptor alpha (ERα) a transcriptional factor that plays an important role in development and progression breast cancer. Yuanhuatine, natural daphnane-type diterpenoid extracted from Daphne genkwa, was reported to exhibit significant cytotoxicity against cells. However, underlying mechanism still unclear. In this study, we evaluated yuanhuatine on two cell lines are ERα-positive -negative. The...
Abstract Objectives Benzo[a]pyrene (B[ a ]P) is member of the polycyclic aromatic hydrocarbon (PAH) family. Although potent carcinogenicity high‐dose B[ ]P has been extensively reported, effects long‐term exposure to on progression tongue squamous cell carcinoma (TSCC) are poorly understood. Methods In present study, TSCC cells were treated with 5 or 50 nM for three months. The proliferation and chemoresistance ]P‐treated 5‐fluorouracil cisplatin detected by CCK8. motility was evaluated...
The comparatively small genome, well elucidated functional genomics and rapid life cycle confer T7 bacteriophage with great advantages for bio-application. Genetic manipulation of genome plays a key role in related applications. As one the important aspects phage genetic modification, gene knock-in refers to two main approaches including direct vitro recombineering. Neither these available methods are efficient enough support development innovative applications capitalizing on bio-system...
Glaucoma is a neurodegenerative disease that affects both the retina and central visual pathway. Magnetization transfer imaging (MTI) sensitive magnetic resonance (MRI) technique can detect degenerative changes in brain.To investigate geniculocalcarine (GCT) striate areas primary glaucoma patients using region of interest (ROI) analysis magnetization ratio (MTR).Twenty with eyes were compared 31 healthy control patients. All participants examined on 3.0 T scanner three-dimensional...