A5085667321- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Adipose Tissue and Metabolism
- Genomics and Chromatin Dynamics
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- Caching and Content Delivery
- Retinoids in leukemia and cellular processes
- Glycosylation and Glycoproteins Research
- Epigenetics and DNA Methylation
Oslo University Hospital
2015-2024
University of Oslo
2015-2024
Norwegian Cancer Society
2019
Transcription factors are abundant Sumo targets, yet the global distribution of along chromatin and its physiological relevance in transcription poorly understood. Using Saccharomyces cerevisiae , we determined genome-wide localization chromatin. We discovered that Sumo-enriched genes almost exclusively involved translation, such as tRNA ribosomal protein (RPGs). Genome-wide expression analysis showed positively regulates their transcription. also consensus motif at RPG promoters is...
Significance How organisms maintain homeostasis when confronted with environmental stress is an important question in biology. The master nutrient response regulator target of rapamycin complex 1 (TORC1) regulates many progrowth cellular processes, including transcription genes required for protein synthesis. RNA polymerase III (RNAPIII) plays a crucial role regulation synthesis by transcribing tRNA genes. RNAPIII activity known to be dependent on TORC1, but the underlying molecular...
Tight control of gene expression networks required for adipose tissue formation and plasticity is essential adaptation to energy needs environmental cues. However, the mechanisms that orchestrate global dramatic transcriptional changes leading adipocyte differentiation remain be fully unraveled. We investigated regulation nascent transcription by sumoylation pathway during using SLAMseq ChIPseq. discovered has a dual function in differentiation; it supports initial downregulation...
Post-translational modification by small ubiquitin-like modifier (Sumo) regulates many cellular processes, including the adaptive response to various types of stress, referred as Sumo stress (SSR). However, it remains unclear whether SSR involves a common set core proteins regardless type or each particular induces stress-specific that targets unique, largely nonoverlapping substrates. In this study, we used MS and Gene Ontology approach identify differentially sumoylated during heat...
Abstract Recycling of nutrients through autophagy is a crucial mechanism for cells to sustain internal stability in fluctuating environment. Dysregulation the process has been associated with range human disorders, and core components have comprehensively outlined. However, limited insight into its systems-wide dynamical control hampered predictive modeling effective vivo manipulation. Here, we mapped yeast genomic influences on dynamics response changes nitrogen levels. Using time-resolved...
Summary Tight control of gene expression networks required for adipose tissue formation and plasticity is essential adaptation to energy needs environmental cues. However, little known about the mechanisms that orchestrate dramatic transcriptional changes leading adipocyte differentiation. We investigated regulation nascent transcription by sumoylation pathway during differentiation using SLAMseq ChIPseq. discovered has a dual function in differentiation; it supports initial downregulation...