A5065171695- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Bioinformatics and Genomic Networks
- Genomic variations and chromosomal abnormalities
- Protein Degradation and Inhibitors
- Cancer Immunotherapy and Biomarkers
- Blood disorders and treatments
- Genomics and Rare Diseases
- Zebrafish Biomedical Research Applications
- interferon and immune responses
- Neuroendocrine Tumor Research Advances
- Ubiquitin and proteasome pathways
- Gene expression and cancer classification
- Immune Cell Function and Interaction
- Plant Molecular Biology Research
- Hematological disorders and diagnostics
- Erythrocyte Function and Pathophysiology
- Plant nutrient uptake and metabolism
- Microtubule and mitosis dynamics
- Chronic Lymphocytic Leukemia Research
- CRISPR and Genetic Engineering
- Pancreatic function and diabetes
- Machine Learning in Bioinformatics
- Hematopoietic Stem Cell Transplantation
- RNA modifications and cancer
Peter MacCallum Cancer Centre
2019-2024
The University of Melbourne
2021-2024
Mayo Clinic
2015-2017
Cincinnati Children's Hospital Medical Center
2015
University of Cincinnati
2015
Indiana University Bloomington
2014
The number of genomics and proteomics experiments is growing rapidly, producing an ever-increasing amount data that are awaiting functional interpretation. A function prediction algorithms were developed improved to enable fast automatic annotation. With the well-defined structure manual curation, Gene Ontology (GO) most frequently used vocabulary for representing gene functions. To understand relationship similarity between GO annotations genes, it important have a convenient pipeline...
Abstract Next Generation Sequencing is now routinely used in the practice of diagnostic pathology to detect clinically relevant somatic and germline sequence variations patient samples. However, clinical assessment copy number (CNVs) large-scale structural (SVs) still challenging. While tools exist estimate both, their results are typically presented separately tables or static plots which can be difficult read unable show context needed for interpretation reporting. We have addressed this...
Bone marrow failure (BMF) related to hypoplasia of hematopoietic elements in the bone is a heterogeneous clinical entity with broad differential diagnosis including both inherited and acquired causes. Accurate diagnostic categorization critical optimal patient care detection genomic variants these patients may provide this important prognostic information. We performed real-time, accredited (ISO15189) comprehensive characterization targeted sequencing whole exome 115 BMF syndrome (median age...
ABSTRACT Zebrafish are an important model for studying phagocyte function, but rigorous experimental systems to distinguish whether phagocyte-dependent effects neutrophil or macrophage specific have been lacking. We developed and validated transgenic lines that enable superior demonstration of cell-autonomous genetic requirements. coupled well-characterized neutrophil- macrophage-specific Gal4 driver with UAS:Cas9 transgenes selective expression Cas9 in either neutrophils macrophages....
Proteins carry out their function in a cell through interactions with other proteins. A large scale protein-protein interaction (PPI) network of an organism provides static yet essential structure interactions, which is valuable clue for understanding the functions proteins and pathways. PPIs are determined primarily by experimental methods; however, computational PPI prediction methods can supplement or verify identified experiment. Here, we developed novel scoring method predicting from...
Richter syndrome (RS), an aggressive lymphoma occurring in the context of chronic lymphocytic leukaemia/small lymphoma, is associated with poor prognosis when treated conventional immunochemotherapy, therefore, improved treatments are required. Immune checkpoint blockade has shown efficacy some B-cell malignancies and modest responses early clinical trials for RS. We investigated immune profile RS as a basis to inform rational therapeutic investigations Formalin-fixed, paraffin-embedded...
An amendment to this paper has been published and can be accessed via a link at the top of paper.