A5000986744- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Respiratory Support and Mechanisms
- Renal Diseases and Glomerulopathies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood disorders and treatments
- Airway Management and Intubation Techniques
- Vascular Procedures and Complications
- Blood groups and transfusion
- Anesthesia and Sedative Agents
- Sepsis Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Acute Myeloid Leukemia Research
- Trauma and Emergency Care Studies
- Cardiovascular and Diving-Related Complications
- Hematological disorders and diagnostics
- Muscle Physiology and Disorders
- Abdominal Trauma and Injuries
- Clinical Laboratory Practices and Quality Control
- Pediatric Pain Management Techniques
- Anesthesia and Pain Management
- Blood transfusion and management
- Immunodeficiency and Autoimmune Disorders
- Telomeres, Telomerase, and Senescence
The University of Queensland
2016-2024
Queensland Children’s Hospital
2020-2022
Brisbane School of Theology
2022
Paterson Public Schools
2022
Queensland Health
2017-2020
Children’s Health Queensland Hospital and Health Service
2016-2018
Thomas Jefferson University
1989-1991
Extracorporeal Life Support (ECLS) risks thrombotic and hemorrhagic complications. Optimal anti-coagulation monitoring is controversial. We compared coagulation tests evaluating the heparin effect in pediatric ECLS.A retrospective study of children (<18yrs) undergoing ECLS over 12 months a tertiary intensive care unit (PICU). Variables included anti-Factor Xa activity (anti-Xa), activated partial thromboplastin time (aPTT), clotting (ACT) thromboelastogram (TEG®6s) parameters: ratio delta...
Children with immune thrombocytopenia for ≥6 months completing a romiplostim study received weekly subcutaneous (1-10 μg/kg targeting platelet counts of 50-200×109/L) in this extension to examine romiplostim's long-term safety and efficacy. Sixty-five children median 2.6 years (range: 0.1-7.0 years). Median baseline age was 11 3-18 years) count 28×109/L 2-458×109/L). No patient discontinued treatment an adverse event. average dose 4.8 mg/kg 0.1-10 mg/kg); remained >50×109/L, starting at week...
Bone marrow failure (BMF) related to hypoplasia of hematopoietic elements in the bone is a heterogeneous clinical entity with broad differential diagnosis including both inherited and acquired causes. Accurate diagnostic categorization critical optimal patient care detection genomic variants these patients may provide this important prognostic information. We performed real-time, accredited (ISO15189) comprehensive characterization targeted sequencing whole exome 115 BMF syndrome (median age...
Context.— Specific reference intervals (RIs) facilitate accurate interpretation of results. Coagulation assay results may vary by demographics and also between reagents analyzers used. Current Thromboelastograph 6s (TEG 6s) Hemostasis Analyzer RIs were generated from adult samples. Objective.— To generate reagent analyzer-specific pediatric for TEG coagulation parameters. Design.— A prospective, observational, single-center study healthy children undergoing general anesthesia (January 3,...
Abstract Background Treatment for chronic immune thrombocytopenia (cITP) in children is largely limited to immunosuppressive agents. Thrombopoietin receptor agonists (TRAs) have been used treat cITP adults over a decade. The objective of this integrated analysis was examine the safety and efficacy TRA romiplostim with ITP. Methods We examined ITP across five trials: final data from two double‐blind placebo‐controlled trials open‐label extensions, interim an ongoing single‐arm trial. Results...
Background Central venous access devices (CVADs) are integral to cancer care provision. Despite the high prevalence of CVAD complications in children with cancer, preventative strategies understudied. Objective The aim this study was assess feasibility, occlusive events, thrombolytic use, adverse and direct costs catheter lock solutions. Methods A single-center, parallel-group, pilot randomized controlled trial undertaken at a tertiary-referral pediatric hospital Australia. Children 18 years...
Introduction Trauma causes 40% of child deaths in high-income countries, with haemorrhage being a leading contributor to death this population. There is growing recognition that fibrinogen and platelets play major role trauma-induced coagulopathy (TIC) but the exact physiological mechanisms are poorly understood. Methods analysis This prospective multicentre, open-label, randomised, two-arm parallel feasibility study conducted emergency departments, intensive care units operating theatres...
Telomere biology disorders (TBDs) are a spectrum of multisystem inherited characterized by bone marrow failure, resulting from mutations in the genes encoding telomerase or other proteins involved maintaining telomere length and integrity. Pathogenicity variants these can be hard to evaluate, because TBD show highly variable penetrance genetic anticipation related inheritance shorter telomeres with each generation. Thus, detailed functional analysis newly identified is often essential....
Pulmonary embolism (PE) is a rare presentation in the pediatric population. We report case of submassive PE an adolescent female following commencement combined oral contraceptive pill (COCP). In setting cardiac dysfunction, she received systemic thrombolysis with significant reduction clot burden and clinical improvement objectively demonstrated shortly thereafter. This highlights challenges decision-making regarding surgical or catheter-based interventions versus medical management...