A5010468648- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- Hip disorders and treatments
- Medical Imaging and Analysis
- Bone fractures and treatments
- Anesthesia and Pain Management
- Bone health and osteoporosis research
- Health and Medical Research Impacts
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Orthopaedic implants and arthroplasty
- Pain Management and Opioid Use
- Cardiac, Anesthesia and Surgical Outcomes
- Bone and Joint Diseases
- Diversity and Career in Medicine
- Bone Metabolism and Diseases
- Innovations in Medical Education
- Musculoskeletal Disorders and Rehabilitation
- Shoulder Injury and Treatment
- Bone Tissue Engineering Materials
- Spinal Hematomas and Complications
- Management of metastatic bone disease
- Australian History and Society
Hospital for Special Surgery
2016-2025
Cornell University
2011-2025
Deutsche Forschungsgemeinschaft
2025
Angelo State University
2024
Lander Institute
2023
University of Washington Medical Center
2018-2023
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2022
National Institutes of Health
2022
Radius Health (United States)
2022
Australian National University
2022
Abstract BACKGROUND Although recent laboratory and population studies suggest that prostate cancer may be responsive to insulin, there is a gap in knowledge concerning the expression of insulin receptors on benign or malignant tissue. METHODS We immunostained 644 cores tissue microarrays prepared from 29 samples without malignancies, 78 Gleason grade 3 cancers, 21 4 cancers 33 5 with antibodies against insulin‐like growth factor I receptor receptor. RESULTS observed immunoreactivity both...
In Brief Study Design. Multi-center, retrospective review. Objective. Identify age associated clinical and radiographic features correlating with AS treatment. Summary of Background Data. Little information exists about factors determining treatment for adult scoliosis (AS). Existing studies have not evaluated stratified differences. Methods. Multicenter, review 290 patients treated AS. Patients divided into operative (OP) or nonoperative (NON), 3 groups (G1 = <50 years, G2 50–65 G3 >65...
Background Several studies have identified risk factors for proximal junctional kyphosis (PJK) after instrumentation scoliosis, but the relative risks are unclear. Questions/purposes We PJK in idiopathic scoliosis and determined their a predictive model. Methods retrospectively reviewed charts of all 249 patients with who underwent surgery from 1996 to 2008. compared those developed did not. performed univariate multivariate analyses determine independent factors. then used Cox...
Study Design. Cross-sectional cohort study. Objective. Describe age-stratified normative values of traditional and novel sagittal alignment parameters. Summary Background Data. Full-body radiographic techniques can capture coronal standing images from the occiput to foot without stitching or vertical distortion. This provides an ideal method evaluate measures global alignment. Methods. Adults with no back neck symptoms were recruited. Age, body mass index, Neck Disability Index, Oswestry...
Study Design. Cross-Sectional Cohort Objective. To describe age-stratified normative values of novel occipitocervical, cervical, and cervicothoracic alignment parameters. Summary Background Data. Full-body radiographic images obtained without stitching or vertical distortion represent an ideal method to evaluate occipitocervical horizontal gaze. Methods. One hundred twenty adults with no back neck symptoms were recruited. Age, sex, body mass index, Neck Disability Index (NDI), Oswestry...
Many receptor tyrosine kinases possess an "activation loop" containing three similarly placed autophosphorylation sites. To examine their roles in the TRK NGF receptor, these residues (Tyr-670, Tyr-674, and Tyr-675) were mutated singly all combinations to phenylalanine stably expressed Trk-deficient PC12nnr5 cells. All mutant receptors showed significantly diminished nerve growth factor (NGF)-stimulated autophosphorylation, indicating impaired catalytic activity. NGF-induced neurite...
KIT receptor kinase activity is repressed, prior to stem cell factor binding, by unknown structural constraints. Using site-directed mutagenesis, we examined the role of intracellular juxtamembrane residues Met-552 through Ile-563 in controlling autophosphorylation. Alanine substitution for Tyr-553, Trp-557, Val-559, or Val-560, all sitting along hydrophobic side an amphipathic α-helix (Tyr-553–Ile-563) predicted Chou-Fasman algorithm, resulted substantially increased spontaneous...
In Brief Study Design. The posterolateral rabbit spinal fusion model was used to assess the effect of intermittent parathyroid hormone on outcomes. Objective. To test hypothesis that (PTH) improves outcomes in model. Summary Background Data. Spinal is definitive management for deformity or instability, yet despite current technology, 5% 40% lumbar fusions result pseudarthrosis. Animal studies have demonstrated enhanced fracture healing with use PTH, but PTH poorly described. Methods....
Recent research work in school leadership highlighting the importance of principals' organizational management skills has prompted scholars to consider their relation instructional skills. However, there is limited empirical that directly compares these and for outcomes. In this study, we use self-ratings construct typologies effectiveness both domains compare relationship student achievement. Our results show principals view themselves as either strong or weak on simultaneously. We also...
Exciting advances continue to be made in numerous areas of orthopaedic research. One the most important research continues discovery biologic solutions degenerative joint disease. Emerging information about genetic basis bone and cartilage pathology is being used provide insight into fundamental mechanisms common conditions such as osteoporosis, disc disease, arthritis. Other active investigation include stem cells, growth factors, tissue engineering, biomaterials, biomechanical properties...
Background The sacro–iliac joint (SIJ) is the largest in human body. When lumbar spine fused to sacrum, motion across SIJ increased, leading increased degeneration of SIJ. Degeneration can become symptomatic up 75% cases when a long fusion ends with sacral fixation. If medical treatments fail, patients undergo surgical fixation Questions/Purposes This study reports results short-term complications, length stay, and clinical as well radiographic outcomes undergoing percutaneous for pain...
Background Shoulder balance for adolescent idiopathic scoliosis (AIS) patients is associated with patient satisfaction and self-image. However, few validated systems exist selecting the upper instrumented vertebra (UIV) post-surgical shoulder balance. Questions/Purposes The purpose to examine existing UIV selection criteria correlate in AIS patients. Methods Patients who underwent spinal fusion at age 10–18 years over a 6-year period were reviewed. All minimum of 1-year radiographic...
Nonbiological total disc replacement is currently being used for the treatment of intervertebral (IVD) disease and injury, but these implants are prone to mechanical wear, tear possible dislodgement. Recently, tissue‐engineered (TE‐TDR) has been investigated as a alternative more fully replicate native IVD properties. However, performance TE‐TDRs not studied in space. In this study, MRI microcomputed tomography imaging rat spine were design collagen (annulus fibrosus)/alginate (nucleus...
Abstract Purpose This study introduces a novel surface-topographic scanning system capable of automatically generating suite objective measurements to characterize torso shape. Research Question : what is the reliability proposed for measurement trunk alignment parameters in patients with adolescent idiopathic scoliosis (AIS) and controls? Methods Forty-six adolescents (26 AIS 20 controls) were recruited prospective study. A series angular, volumetric, area measures computed from topographic...